Amsden, Brian - Queen's University - Department of Chemical Engineering

个人简介

Our polymer lab is located within the Biosciences Complex and currently has a Waters HPLC (UV-VIS, fluorescence) and GPC system complete with a Precision Detectors light-scattering detector, a Mettler-Toledo differential scanning calorimeter,a Biolin Quartz Crystal Microbalance with Dissipation, and an Instron tensile tester. Our cell culture and microscopy facilities are located in the Human Mobility Research Centre, where we presently have an Olympus FV1000 confocal microscope, a Nicolet ATR-FTIR microscope, and a Zeiss fluorescence microscope. Frequent use is made of the NMR and MS facilities in the Department of Chemistry, and a rheometer and dynamic mechanical analyzer within the Polymer Group Analytical Facility.

研究领域

Our research focus is on the creation of effective biodegradable and biocompatible polymers for biomedical applications. These applications include localized growth factor delivery for therapeutic angiogenesis and for stem cell differentiation, scaffolds for soft connective tissue engineering, and ocular drug delivery. Polymer systems being developed include biodegradable elastomers,electrospun crimped fibre scaffolds, injectable thermoplastics, and mechanically enhanced hydrogels. We are interested in elucidating the mechanisms of degradation of the polymers in vivo to better design these materials for given applications, determining the mechanisms governing drug release, the role polymer biomaterial mechanical properties play in mediating cell proliferation and differentiation, and in controlling polymer surface properties to improve cellular interactions. The work is multidisciplinary and we collaborate routinely with orthopaedic and cardiovascular surgeons, and colleagues in mechanical engineering and cell biology.

近期论文

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H.K. Cheung, T. Han, D.M. Marecak, J.F. Watkins, and L.E. Flynn, "Composite hydrogel scaffolds incorporating decellularized adipose tissue for soft tissue engineering with adipose-derived stem cells," Biomaterials 35, 1914-1923, 2014 [More information]. JWS Hayami, SD Waldman, BG Amsden, "Injectable, high modulus and fatigue resistant, composite scaffold for load-bearing soft tissue regeneration," Biomacromolecules 14, 4236-4247, 2013 [More information]. I.O. Babasola, M. Rooney, BG Amsden, "Co-release of bioactive VEGF and HGF from liquid injectable poly(5-ethylene ketal ε-caprolactone-co-D,L-lactide)," Molecular Pharmaceutics 10, 4552-4559, 2013 [More information]. MC Vyner, L Liu, HD Sheardown, and BG Amsden, "Elastomer crosslink density affects protein adsorption," Biomaterials 34, 9287-9284, 2013 [More information]. O.I. Babasola, BG Amsden, "Osmotically driven protein release from liquid injectable polymers based on 5-ethylene ketal ε-caprolactone: potential and mechanism," Eur J Pharm Biopharm 85, 765-772, 2013 [More information]. C. Yu, S. Young, V. Russo, B.G. Amsden, and L.E. Flynn, "Techniques for the isolation of high quality RNA from cells encapsulated in chitosan hydrogels," Tissue Engineering C 19, 11, 829-838, 2013. L.A. Cornacchionne, B. Qi, J.Bianco, Z. Zhou, B.G. Amsden, "Photo-cross-linked poly(ethylene carbonate) elastomers: synthesis, in vivo degradation, and determination of in vivo degradation mechanism," Biomacromolecules 13, 10, 3099-3107, 2012 [More information]. D.C. Surrao, S.D. Waldman, and B.G. Amsden, "Biomimetic poly(lactide)-based fibrous scaffolds for ligament tissue engineering,"Acta Biomaterialia 8, 11, 3997-4006, 2012 [More information]. A. Sukarto, C. Yu, LE Flynn, B.G. Amsden, "Co-delivery of adipose-derived stem cells and growth factor-loaded microspheres in RGD-grafted N-methacrylate glycol chitosan gels for focal chondral repair," Biomacromolecules 13, 2490-2502, 2012 [More information]. O.I. Babasola, J. Bianco, and BG Amsden, "In vivo degradation and tissue response to poly(5-ethylene ketal e-caprolactone-co-D,L-lactide)”," Biomacromolecules 13, 2211-2217, 2012 [More information]. D.C. Surrao, J.Y.C. Fan, S.D. Waldman, and B.G. Amsden, "A crimp-like microarchitecture improves tissue production in fibrous ligament scaffolds in response to mechanical stimuli," Acta Biomaterialia 8, 10, 3704-3713, 2012 [More information]. A. Sukarto, BG. Amsden, "Low melting point amphiphilic microspheres for delivery of bone morphogenetic protein-6 and transforming growth factor β-3 in a hydrogel matrix," J Controlled Release 158, 23-62, 2012 [More information]. R. Chapanian, MY Tse, SC Pang, and BG Amsden, "Osmotic release of bioactive VEGF from biodegradable elastomer monoliths is the same in vivo as in vitro," J Pharm Sci 101, 588-597, 2012 [More information]. O.I. Babasola, BG Amsden, "Surface eroding, liquid injectable polymers based on 5-ethylene ketal ε-caprolactone,"Biomacromolecules 12, 10, 3423-3431, 2011 [More information]. JWS Hayami, SD Waldman, BG Amsden, "A photocurable hydrogel-elastomer composite scaffold with bi-continuous morphology for cell encapsulation," Macromolecular Bioscience 12, 1672-83, 2011 [More information]. DC Surrao, AA. Khan, AJ. McGregor, JCY Fan, B.G. Amsden, SD Waldman, "Can Microcarrier Expanded Chondrocytes Synthesize Functional Tissue In Vitro," Tissue Engineering A 17, 1959-67, 2011. AJ McGregor, BG Amsden, SD Waldman, "Chondrocyte repopulation of the zone of death induced by osteochondral harvest,"Osteoarthritis and Cartilage 19, 2, 242-248, 2011. R. Chapanian, M.Y. Tse, S.C. Pang, and B.G. Amsden, "Long term in vivo degradation and tissue response to photo-cross-linked elastomers prepared from star-shaped prepolymers of poly(ε-caprolactone-co-D,L-lactide)," J Biomed Mater Res A 92A, 830-842, 2010. B. Ilagan and B.G. Amsden, "Macroporous photocrosslinked elastomer scaffolds containing microporosity: preparation and in vitro degradation properties," J. Biomed. Mater. Res. A 93A, 211-218, 2010. J. Hayami, D. Surrao, S.D. Waldman, and B.G. Amsden, "Composite scaffold for ligament tissue engineering," J. Biomed. Mater. Res. A 92A, 1407-1420, 2010. R. Chapanian and B.G. Amsden, "Osmotically driven protein release from photo-cross-linked elastomers of poly(trimethylene carbonate) and poly(trimethylene carbonate-co-D,L-lactide)," Eur. J. Pharm. Biopharm. 74, 172-183, 2010. R. Chapanian and B.G. Amsden, "Combined and sequential delivery of bioactive VEGF165 and HGF from poly(trimethylene carbonate) based photo-cross-linked elastomers," J. Controlled Release 143, 53-63, 2010. B. Amsden and B. Qi, "Anti-atherosclerotic peptide delivery from a photocrosslinkable biodegradable network," Int. J. Pharmaceutics 388, 32-39, 2010. L. Timbart, MY Tse, SC Pang, and BG Amsden, "Tissue response to, and degradation rate of, photocrosslinked trimethylene carbonate-based elastomers following intramuscular implantation," Materials: Special Issue Advances in Biomaterials 3, 2, 1156-1171, 2010. B. Amsden, "Liquid, injectable, hydrophobic and biodegradable polymers as drug delivery vehicles," Macromolecular Bioscience10, 8, 825-835, 2010.