个人简介

BA Cambridge University, 1960 MA Cambridge University, 1963 PhD Cambridge University, 1963 Research Fellow, Queens' College, Cambridge, 1962-66 Research Associate and Fulbright Grantee, Massachusetts Institute of Technology, 1963-64 NATO Fellow, Cambridge University, 1964-66 Assistant Professor of Chemistry, SUNY at Albany, 1966-1971 Associate Professor of Chemistry, Virginia Tech, 1971-1977 Professor of Chemistry, Virginia Tech, 1977-1999 University Distinguished Professor, Virginia Tech, 1999-present

研究领域

Bioorganic

Natural products have made a major contribution to drug discovery and especially to cancer chemotherapy, with paclitaxel (Taxol) being the best-selling anticancer drug in history. Research in our group is focused on the chemistry of biologically active natural products related to cancer and malaria. In the cancer area we are involved in a search for novel anti-cancer agents from Nature in a major collaborative project seeking to combine drug discovery and biodiversity conservation in Madagascar. Plant, marine, and microbial extracts are fractionated using selective bioassays to guide the fractionation, and structure elucidation is carried out primarily by spectroscopic methods. In some cases synthetic approaches to the isolated compounds are also employed, in order to confirm structures and to obtain adequate material for biological testing. Casearlucin A and ipomoeassin A are examples of compounds isolated in this work. A second cancer-related project involves improved methods of delivery of the drug Taxol to tumors. Gold nanoparticles are being used in one approach, and the development of Taxol analogs with selective activity for certain classes of its molecular target tubulin is a second approach. In the malaria area we have joined forces with the Walter Reed Army Institute of Research and Georgetown University to discover new antimalarial compounds from the superb National Cancer Institute Repository of natural products, and we have also partnered with Professor Belen Cassera in the Department of Biochemistry to examine the Merck Repository of natural products for antimalarial compounds.

近期论文

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Kingston, D. G. I. Modern Natural Products Drug Discovery and its Relevance to Biodiversity Conservation. J. Nat. Prod. 2011, 74, 496-511. http://pubs.acs.org/doi/full/10.1021/np100550t Chen, Q.-H.; Ganesh, T.; Jiang, Y.; Banerjee, A.; Sharma, S.; Bane, S.; Snyder, J. P.; Kingston, D. G. I. Novel Epothilone Lactones by an Unusual Diversion of the Grubbs’ Metathesis Reaction. Chem. Commun. 2010, 46, 2019-2021. http://pubs.rsc.org/en/content/articlepdf/2010/cc/b926174e?page=search Kingston, D. G. I. Tubulin-Interactive Natural Products as Anticancer Agents. J. Nat. Prod. 2009, 72, 507-515. http://pubs.acs.org/doi/full/10.1021/np800568j Kingston, D. G. I. A Natural Love of Natural products. J. Org. Chem. 2008, 73, 3975-3984. http://pubs.acs.org/doi/pdf/10.1021/jo800239a Paik, Y.; Yang, C.; Metaferia, B.; Tang, S.; Bane, S.; Ravindra, R.; Shanker, N.; Alcaraz, A. A.; Johnson, S. A.; Schaefer, J.; O'Connor, R. D.; Cegelski, L.; Snyder, J. P.; Kingston, D. G. I. Rotational-Echo Double-Resonance NMR Distance Measurements for the Tubulin-Bound Paclitaxel Conformation. J. Am. Chem. Soc. 2007, 129, 361-370. http://pubs.acs.org/doi/pdf/10.1021/ja0656604 Cao, S.; Guza, R. C.; Wisse, J. H.; Evans, R.; van der Werff, H.; Miller, J. S.; Kingston, D. G. I. Ipomoeassins A-E, Five New Cytotoxic Macrocyclic Glycoresins, from the Leaves of Ipomoea squamosa from the Suriname Rainforest. J. Nat. Prod. 2005, 68, 487-492. http://pubs.acs.org/doi/pdf/10.1021/np049629w Ganesh, T.; Guza, R. C.; Bane, S.; Ravindra, R.; Shanker, N.; Lakdawala, A. S. Snyder, J. P.; Kingston, D. G. I. The Bioactive Taxol Conformation on b-tubulin: Experimental Evidence from Highly Active Constrained Analogs. Proc. Natl. Acad. Sci USA, 2004, 101, 10006-10011. http://www.pnas.org/content/101/27/10006.full.pdf