Wüster, Wolfgang - Bangor University - School of Biological Sciences

个人简介

Offices held Committees: SBS Board of Studies Groups: SBS Academic Staff SBS Teaching Staff

研究领域

Dr Wolfgang Wüster has a wide-ranging research portfolio encompassing the origin and evolution of snake venoms, the systematics, ecology and evolutionary biology of snakes, and phylogeographic studies. Recent research highlights include: (i) unravelling of the dynamic evolution of snake venom toxins through participation in the king cobra genome project and the analysis of toxin and non-toxin gene sequences. Noteworthy discoveries include the complex patterns of recruitment and reverse recruitment of toxin genes from ordinary physiological protein genes, the role of gene duplications in toxin evolution, and the mechanisms behind the evolution of medically important toxin families. (ii) evidence for the effects of natural selection for different prey in determining the evolution of venom composition in snakes (iii) highlighting hitherto unsuspected biogeographical and phylogeographical patterns in widespread African and Middle Eastern venomous snakes (iv) the discovery of several cryptic species of venomous snakes. Ongoing research focusses on the extrinsic and intrinsic factors shaping geographic patterns of variation in venom composition in snakes and their underlying genetic mechanisms, and the biogeography and systematics of multiple groups of venomous snakes . This research programme has been funded by the Leverhulme Trust, NERC and the Systematics Association.

近期论文

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Ujvari, B., N.R. Casewell, K. Sunagar, K. Arbuckle, W. Wüster, N. Lo, D. O’Meally, C. Beckmann, G.F. King, E. Deplazes & T. Madsen (2015) Widespread convergence in toxin resistance by predictable molecular evolution. PNAS, 112(38): 11911-11916. PDF: http://www.pnas.org/content/112/38/11911. Maddock, S.T., R.J. Ellis, P. Doughty, L.A. Smith & W. Wüster (2015) A new species of death adder (Acanthophis: Serpentes: Elapidae) from north-western Australia. Zootaxa, 4007(3): 301-326. PDF: http://www.mapress.com/zootaxa/2015/f/zt04007p326.pdf Rhodin, A.G.J., H. Kaiser, P.P. van Dijk, W. Wüster, M. O’Shea, M. Archer, M. Auliya, L. Boitani, R. Bour, V. Clausnitzer, T. Contreras-MacBeath, B.I. Crother, J.M. Daza, C.A. Driscoll, O. Flores-Villela, J. Frazier, U. Fritz, A. Gardner, C. Gascon, A. Georges, F. Glaw, F.G. Grazziotin, C.P. Groves, G. Haszprunar, P. Havaš, J.M. Hero, M. Hoffmann, M.S. Hoogmoed, B.D. Horne, J.B. Iverson, M. Jäch, C.L. Jenkins, R.K.B. Jenkins, A.R. Kiester, J.S. Keogh, T.E. Lacher Jr., J.E. Lovich, L. Luiselli, D.L. Mahler, D. Mallon, R. Mast, R.W. Mcdiarmid, J. Measey, R.A. Mittermeier, S. Molur, V. Mossbrugger, R. Murphy, D. Naish, M. Niekisch, H. Ota, J.F. Parham, M.J. Parr, N.J. Pilcher, R.H. Pine, A.B. Rylands, J.G. Sanderson, J. Savage, W. Schleip, G.J. Scrocchi, H.B. Shaffer, E.N. Smith, R. Sprackland, S.N. Stuart, H. Vetter, L.J. Vitt, T. Waller, G. Webb, E.O. Wilson, H. Zaher, and S. Thomson (Corresponding Author). 2015. Comment on Spracklandus Hoser, 2009 (Reptilia, Serpentes, ELAPIDAE): request for confirmation of the availability of the generic name and for the nomenclatural validation of the journal in which it was published. (Case 3601; see BZN 70: 234–237; 71: 30–38, 133–135, 181–182, 252–253). Bulletin of Zoological Nomenclature 72(1): 65-78. PDF: https://www.dropbox.com/s/fcdgoevveb8brer/2015_Rhodin_BZN.pdf?dl=0 Mrinalini, J.J. Hicks & W. Wüster (2015) Natural History notes: Crotalus scutulatus (Mohave rattlesnake). Maximum size. Herpetological Review, 46(2): 271. PDF: https://www.dropbox.com/s/0ovxs6xiinz548j/2015_ElMofo.pdf?dl=0 Casewell, N.C., S.C. Wagstaff, W. Wüster, D.A.N. Cool, F.M.S. Bolton, S.I. King, D. Pla, L. Sanz, J.J. Calvete & R.A. Harrison (2014) Medically important differences in snake venom composition are dictated by distinct post-genomic mechanisms. PNAS, 111: 9205-9210. http://www.pnas.org/content/111/25/9205 Vonk, F.J., N.R. Casewell, C.V. Henkel, A. Heimberg, R.J.R. McCleary, H.M.E. Kerkkamp, R. Vos, E. McGlinn, I. Guerreiro, J.J. Calvete, W. Wüster, J.M. Logan, A.E. Woods, R.A. Harrison, T.A. Castoe, A.P.J. de Koning, D.D. Pollock, C. Renjifo, R.B. Currier, D. Salgado, D. Pla, L. Sanz, H.P. Spaink, H.J. Jansen, A.S. Hyder, J.M.C. Ribeiro, P.W. Arntzen, G.E.E.J. van den Thillart, M. Boetzer, W. Pirovano, R.P. Dirks, D. Duboule, R.M. Kini & M.K. Richardson (2013) King cobra genome reveals dynamic gene evolution and adaptation in the snake venom system. PNAS 110 (51): 20651-20656. PDF: http://www.pnas.org/content/110/51/20651.full Casewell, N.R., W. Wüster, F.J. Vonk, R.A. Harrison & B.G. Fry (2013) Complex cocktails: the evolutionary novelty of venoms. Trends in Ecology and Evolution. 28: 219-229. PDF: https://db.tt/T7usfmen Barlow, A., K. Baker, C.R. Hendry, L. Peppin, T. Phelps, K.A. Tolley, C.E. Wüster & W. Wüster (2013) Phylogeography of the widespread African puff adder (Bitis arietans) reveals multiple Pleistocene refugia in southern Africa. Molecular Ecology, 22: 1134-1157. PDF: https://db.tt/h60pkdzT Kaiser, H., B.I. Crother, C.M.R. Kelly, L. Luiselli, M. O’Shea, H. Ota, P. Passos, W.D. Schleip & W. Wüster (2013) Best practices: in the 21st Century, taxonomic decisions in herpetology are acceptable only when supported by a body of evidence and published via peer-review. Herpetological Review 44: 8-23. PDF: https://db.tt/291qaDGP Casewell, N.R., G.A. Huttley & W. Wüster (2012) Dynamic evolution of venom proteins in squamate reptiles. Nature Communications, 3(1066): 1-10. PDF: https://db.tt/0iD46mNu Barlow, A., W. Grail, M. de Bruyn & W. Wüster (2012) Anonymous nuclear markers for the African adders (Serpentes: Viperidae: Bitis). Conservation Genetics Resources, 4:967-969. PDF: https://db.tt/1wZ1aBmK Fry, B.G.,, N.R. Casewell, W. Wüster, N. Vidal, B. Young & T.N.W. Jackson (2012) The structural and functional diversiﬁcation of the Toxicofera reptile venom system. Toxicon, 60: 434-448. PDF: https://db.tt/L4y28z3W Richards, D.P., A. Barlow & W. Wüster. (2012) Venom lethality and diet: Differential responses of natural prey and model organisms to the venom of the saw-scaled vipers (Echis), Toxicon, 59: 110-116. PDF: https://db.tt/HYuX7kDw Casewell, N.R., S.C. Wagstaff, R.A. Harrison, C.Renjifo & W. Wüster (2011) Domain loss facilitates accelerated evolution and neofunctionalization of duplicate snake venom metalloproteinase toxin genes. Molecular Biology and Evolution 28: 2637-2649. PDF: https://db.tt/UCKImI6U Williams, D.J., J.-M. Gutiérrez, J.J. Calvete, W. Wüster, K. Ratanabanangkoon, O. Paiva, N.I. Brown, N.R. Casewell, R.A. Harrison, P.D. Rowley, M. O’Shea, S.D. Jensen, K.D. Winkel & D.A. Warrell (2011) Ending the drought: new strategies for improving the flow of affordable, effective antivenoms in Asia and Africa. Journal of Proteomics, 74: 1735-1767. PDF: https://db.tt/uBm9zfge Casewell, N.R., S.C. Wagstaff, R.A. Harrison & W. Wüster (2011) Gene tree parsimony of multi-locus snake venom protein families reveals species tree conflict as a result of multiple parallel gene loss. Molecular Biology and Evolution, 28: 1157–1172. PDF: https://db.tt/lIi1mb7c Wüster, W. & Bérnils, R.S. (2011) On the generic classification of the rattlesnakes, with special reference to the Neotropical Crotalus durissus complex (Squamata: Viperidae). Zoologia 28: 417–419. PDF: http://www.scielo.br/pdf/zool/v28n4/v28n4a01.pdf Casewell, N.R., D.A.N. Cook, S.C. Wagstaff, A. Nasidi, N. Durfa, W. Wüster & R.A. Harrison (2010) Pre-clinical assays predict pan-African Echis viper efficacy for a species-specific antivenom. PLoS Neglected Tropical Diseases, 4: e851. DOI: 10.1371/journal.pntd.0000851 Antonelli, A., A. Quijada-Mascareñas, A.J. Crawford, J.M. Bates, P.M. Velazco & W. Wüster (2010) Molecular studies and phylogeography of Amazonian tetrapods and their relation to geological and climatic models. In Amazonia: Landscape and Species Evolution (C. Hoorn, F. Wesselingh & H. Vonhoff, eds.), p. 386-404. Blackwell Publishing, Oxford. PDF: https://db.tt/znZzRJdJ Casewell, N.R., R.A. Harrison, W. Wüster & S.C. Wagstaff (2009) Comparative venom gland transcriptome surveys of the saw-scaled vipers (Viperidae: Echis) reveal substantial intra-family gene diversity and novel venom proteins. BMC Genomics 10: 564. PDF: http://www.biomedcentral.com/1471-2164/10/564 Pook, C.E., U. Joger, N. Stümpel & W. Wüster (2009) When continents collide: phylogeny, historical biogeography and systematics of the medically important viper genus Echis (Squamata: Serpentes: Viperidae). Molecular Phylogenetics and Evolution 53: 792-807. PDF: https://db.tt/aSpzbElu Trape, J.-F., L. Chirio, D.G. Broadley & W. Wüster (2009) Phylogeography and systematic revision of the Egyptian cobra (Serpentes: Elapidae: Naja haje) species complex, with the description of a new species from West Africa. Zootaxa 2236: 1-25. PDF: http://www.mapress.com/zootaxa/2009/f/zt02236p025.pdf Wallach, V., W. Wüster & D.G. Broadley (2009) In praise of subgenera: taxonomic status of cobras of the genus Naja Laurenti (Serpentes: Elapidae). Zootaxa 2236: 26-36. PDF: http://www.mapress.com/zootaxa/2009/f/zt02236p036.pdf