Tomos, A Deri - Bangor University - School of Biological Sciences

个人简介

Offices held Committees: SBS Board of Studies Groups: SBS Academic Staff SBS Teaching Staff

研究领域

Professor Deri Tomos leads a group investigating the behaviour of individual cells within complex organs of crops and other plants. Under the name of Single Cell Sampling and Analysis (SiCSA), this involves their biophysics (mechanics and water relations), biochemistry (metabolites and inorganic ions) and molecular biology (gene expression). More recently this has involved quantification of gene expression in single cells and on exploring methods to run single cell microarray analysis. Currently the group is developing mass spectrometry techniques (both FT-ICR-MS and MALDI-TOF – funded by BBSRC SRIF) to analyse single cell metabolites, and the use of multiphoton confocal microscopy to extend the range of cells that can be sampled or analysed in situ. Both MS techniques are also being used in global metabolome analyses. A project to exploit the joint application of biophysical (atomic force microscopy) and reporter gene technology to study cellular structures has also recently started. Current funding is also supporting the application of these ultra-fine spatial analyses to the soil component of the rhizosphere and the behaviour of depleted uranium.

近期论文

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Edwards-jones, G., Canals, LMI., Hounsome, N., Truninger, M., Koerber, G., Hounsome, B., Cross, P., York, EH., Hospido, A., Plassmann, K., Harris, IM., Edwards, RT., Day, GAS., Tomos, AD., Cowell, SJ., Jones, DL., (2008) Testing the assertion that 'local food is best': the challenges of an evidence-based approach, Trends in Food Science & Technology, 19(5), 265-274. Love, AJ., Laval, V., Geri, C., Laird, J., Tomos, AD., Hooks, MA., Milner, JJ., (2007) Components of Arabidopsis defense- and ethylene-signaling pathways regulate susceptibility to Cauliflower mosaic virus by restricting long-distance movement, Molecular Plant-microbe Interactions, 20(6), 659-670. Roberts, K., Love, AJ., Laval, V., Laird, J., Tomos, AD., Hooks, MA., Milner, JJ., (2007) Long-distance movement of Cauliflower mosaic virus and host defence responses in Arabidopsis follow a predictable pattern that is determined by the leaf orthostichy, New Phytologist, 175(4), 707-717. Farrell, AD., Ougham, HJ., Tomos, AD., (2006) The effect of gibberellic acid on the response of leaf extension to low temperature, Plant Cell and Environment, 29(7), 1329-1337. Voitsekhovskaja, OV., Koroleva, OA., Batashev, DR., Knop, C., Tomos, AD., Gamalei, YV., Heldt, HW., Lohaus, G., (2006) Phloem loading in two Scrophulariaceae species. What can drive symplastic flow via plasmodesmata?, Plant Physiology, 140(1), 383-395. Pritchard, J., Tomos, AD., Farrar, JE., Minchin, PEH., Gould, N., Paul, MJ., Macrae, EA., Ferrieri, RA., Gray, DW., Thorpe, MR., (2004) Turgor, solute import and growth in maize roots treated with galactose, Functional Plant Biology, 31(11), 1095-1103. Darwent, MJ., Paterson, E., Mcdonald, AJS., Tomos, AD., (2003) Biosensor reporting of root exudation from Hordeum vulgare in relation to shoot nitrate concentration, Journal of Experimental Botany, 54(381), 325-334. Kenny, DA., Humpherson, PG., Leese, HJ., Morris, DG., Tomos, AD., Diskin, MG., Sreenan, JM., (2002) Effect of elevated systemic concentrations of ammonia and urea on the metabolite and ionic composition of oviductal fluid in cattle, Biology of Reproduction, 66(6), 1797-1804. Koroleva, OA., Tomos, AD., Farrar, J., Pollock, CJ., (2002) Changes in osmotic and turgor pressure in response to sugar accumulation in barley source leaves, Planta, 215(2), 210-219. Laval, V., Koroleva, OA., Murphy, E., Lu, CG., Milner, JJ., Hooks, MA., Tomos, AD., (2002) Distribution of actin gene isoforms in the Arabidopsis leaf measured in microsamples from intact individual cells, Planta, 215(2), 287-292. Lu, CG., Koroleva, OA., Farrar, JF., Gallagher, J., Pollock, CJ., Tomos, AD., (2002) Rubisco small subunit, chlorophyll a/b-binding protein and sucrose : fructan-6-fructosyl transferase gene expression and sugar status in single barley leaf cells in situ. Cell type specificity and induction by light, Plant Physiology, 130(3), 1335-1348. Koroleva, OA., Tomos, AD., Farrar, JF., Gallagher, J., Pollock, CJ., (2001) Carbon allocation and sugar status in individual cells of barley leaves affects expression of Sucrose: Fructan 6- Fructosyltransferase gene, Annals of Applied Biology, 138(1), 27-32. Tomos, AD., Sharrock, RA., (2001) Cell sampling and analysis (SiCSA): metabolites measured at single cell resolution, Journal of Experimental Botany, 52(356), 623-630. Korolev, AV., Tomos, AD., Farrar, JF., (2000) The trans-tissue pathway and chemical fate of C-14 photoassimilate in carrot taproot, New Phytologist, 147(2), 299-306. Koroleva, OA., Davies, A., Deeken, R., Thorpe, MR., Tomos, AD., Hedrich, R., (2000) Identification of a new glucosinolate-rich cell type in Arabidopsis flower stalk, Plant Physiology, 124(2), 599-608. Tomos, AD., Leigh, RA., (1999) The pressure probe: A versatile tool in plant cell physiology, Annual Review of Plant Physiology and Plant Molecular Biology, 50, 447-+. Bazzanella, A., Lochmann, H., Tomos, AD., Bachmann, K., (1998) Determination of inorganic cations and anions in single plant cells by capillary zone electrophoresis, Journal of Chromatography a, 809(1-2), 231-239. Hinde, P., Richardson, P., Koyro, HW., Tomos, AD., (1998) Quantitative X-ray microanalysis of solutes in individual plant cells: a comparison of microdroplet and in situ frozen-hydrated data, Journal of Microscopy-oxford, 191, 303-310. Koroleva, OA., Farrar, JF., Tomos, AD., Pollock, CJ., (1998) Carbohydrates in individual cells of epidermis, mesophyll, and bundle sheath in barley leaves with changed export or photosynthetic rate, Plant Physiology, 118(4), 1525-1532. Koroleva, OA., Farrar, JF., Tomos, AD., Pollock, CJ., (1997) Patterns of solute in individual mesophyll, bundle sheath and epidermal cells of barley leaves induced to accumulate carbohydrate, New Phytologist, 136(1), 97-104. Price, AH., Tomos, AD., Virk, DS., (1997) Genetic dissection of root growth in rice (Oryza sativa L) .1. a hydrophonic screen, Theoretical and Applied Genetics, 95(1-2), 132-142. Price, AH., Tomos, AD., (1997) Genetic dissection of root growth in rice (Oryza sativa L) .2. mapping quantitative trait loci using molecular markers, Theoretical and Applied Genetics, 95(1-2), 143-152. Price, AH., Young, EM., Tomos, AD., (1997) Quantitative trait loci associated with stomatal conductance, leaf rolling and heading date mapped in upland rice (Oryza sativa), New Phytologist, 137(1), 83-91. Griffiths, A., Parry, AD., Jones, HG., Tomos, AD., (1996) Abscisic acid and turgor pressure regulation in tomato roots, Journal of Plant Physiology, 149(3-4), 372-376.