Shirsat, Anil Harishchandra - Bangor University - School of Biological Sciences

个人简介

Offices held Committees: SBS Board of Studies Groups: SBS Academic Staff SBS Teaching Staff

研究领域

Dr Anil Shirsat is interested in the molecular mechanisms which remodel the cell wall in response to biotic and abiotic stresses. To this end, he has isolated cell wall protein extensin genes from Brassica napus and Arabidopsis. He was able to show that extensin cell wall proteins, whose role in plants was unclear, are responsible for wall strengthening, and that their synthesis is regulated by the degree of mechanical stress experienced by the tissue. Stress-regulated extensin promoter elements have been identified, and a U.K. patent was awarded (1997) to develop these elements as molecular switches. More recently (2006), he has shown that over-expressing extensin genes in Arabidopsis leads to a significant and dramatic reduction in bacterial pathogen invasiveness – this finding has the considerable advantage that it will not be susceptible to failure – thereby overcoming the major problem of pathogen resistance based on R/Avr interactions. If this novel form of resistance transfers to other crop species and is active against fungal pathogens, it has the potential to revolutionise the crop seed market place by producing crops that are more robust and offer a better return on spend through the crop lifecycle, significantly reducing wastage due to pathogen attack. A second patent (2005) has been awarded to protect this finding, and research in the lab is currently aimed at exploiting the commercial potential of this discovery.

近期论文

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Roberts, K., Shirsat, AH., (2006) Increased extensin levels in Arabidopsis affect inflorescence stem thickening and height, Journal of Experimental Botany, 57(3), 537-545. Wei, G., Shirsat, AH., (2006) Extensin over-expression in Arabidopsis limits pathogen invasiveness, Molecular Plant Pathology, 7(6), 579-592. Merkouropoulos, G., Shirsat, AH., (2003) The unusual Arabidopsis extensin gene atExt1 is expressed throughout plant development and is induced by a variety of biotic and abiotic stresses, Planta, 217(3), 356-366. Shirsat, AH., Thomson, HEC., Elliott, KA., (2003) The Brassica napus extA extensin gene negative regulatory region controls expression in response to mechanical stresses, Plant Cell and Environment, 26(10), 1647-1655. Merkouropoulos, G., Barnett, DC., Shirsat, AH., (1999) The Arabidopsis extensin gene is developmentally regulated, is induced by wounding, methyl jasmonate, abscisic and salicylic acid, and codes for a protein with unusual motifs, Planta, 208(2), 212-219. Elliott, KA., Shirsat, AH., (1998) Promoter regions of the extA extensin gene from Brassica napus control activation in response to wounding and tensile stress., Plant Molecular Biology, 37(4), 675-687. Kozbial, PZ., Jerzmanowski, A., Shirsat, AH., Kacperska, A., (1998) Transient freezing regulates expression of extensin-tgpe genes in winter oilseed rape, Physiologia Plantarum, 103(2), 264-270. Shirsat, AH., Bell, A., Spence, J., Harris, JN., (1996) The Brassica napus extA extensin gene is expressed in regions of the plant subject to tensile stresses, Planta, 199(4), 618-624. Shirsat, AH., Wieczorek, D., Kozbial, P., (1996) A gene for Brassica napus extensin is differentially expressed on wounding, Plant Molecular Biology, 30(6), 1291-1300. Shirsat, AH., Wilford, N., Evans, IM., Gatehouse, LN., Croy, RRD., (1991) EXPRESSION OF A BRASSICA-NAPUS EXTENSIN GENE IN THE VASCULAR SYSTEM OF TRANSGENIC TOBACCO AND RAPE PLANTS, Plant Molecular Biology, 17(4), 701-709. Boulter, ME., Croy, E., Simpson, P., Shields, R., Croy, RRD., Shirsat, AH., (1990) TRANSFORMATION OF BRASSICA-NAPUS L (OILSEED RAPE) USING AGROBACTERIUM-TUMEFACIENS AND AGROBACTERIUM-RHIZOGENES - A COMPARISON, Plant Science, 70(1), 91-99, Hatamoto, H., Boulter, ME., Shirsat, AH., Croy, EJ., Ellis, JR., (1990) RECOVERY OF MORPHOLOGICALLY NORMAL TRANSGENIC TOBACCO FROM HAIRY ROOTS CO-TRANSFORMED WITH AGROBACTERIUM-RHIZOGENES AND A BINARY VECTOR PLASMID, Plant Cell Reports, 9(2), 88-92, Shirsat, AH., Meakin, PJ., Gatehouse, JA., (1990) SEQUENCES 5' TO THE CONSERVED 28 BP LEG BOX ELEMENT REGULATE THE EXPRESSION OF PEA SEED STORAGE PROTEIN GENE LEGA, Plant Molecular Biology, 15(5), 685-693. Shirsat, A., Wilford, N., Croy, R., Boulter, D., (1989) SEQUENCES RESPONSIBLE FOR THE TISSUE SPECIFIC PROMOTER ACTIVITY OF A PEA LEGUMIN GENE IN TOBACCO, Molecular & General Genetics, 215(2), 326-331, Shirsat, AH., Wilford, N., Croy, RRD., (1989) GENE COPY NUMBER AND LEVELS OF EXPRESSION IN TRANSGENIC PLANTS OF A SEED SPECIFIC GENE, Plant Science, 61(1), 75-80, Croy, RRD., Evans, IM., Yarwood, JN., Harris, N., Gatehouse, JA., Shirsat, AH., Kang, A., Ellis, JR., Thompson, A., Boulter, D., (1988) EXPRESSION OF PEA LEGUMIN SEQUENCES IN PEA, NICOTIANA AND YEAST, Biochemie Und Physiologie Der Pflanzen, 183(2-3), 183-197, Ellis, JR., Shirsat, AH., Hepher, A., Yarwood, JN., Gatehouse, JA., Croy, RRD., Boulter, D., (1988) TISSUE-SPECIFIC EXPRESSION OF A PEA LEGUMIN GENE IN SEEDS OF NICOTIANA-PLUMBAGINIFOLIA, Plant Molecular Biology, 10(3), 203-214, Shirsat, AH., (1988) A TRANSPOSON-LIKE STRUCTURE IN THE 5' FLANKING SEQUENCE OF A LEGUMIN GENE FROM PISUM-SATIVUM, Molecular & General Genetics, 212(1), 129-133, Boulter, D., Evans, IM., Ellis, JR., Shirsat, A., Gatehouse, JA., Croy, RRD., (1987) DIFFERENTIAL GENE-EXPRESSION IN THE DEVELOPMENT OF PISUM-SATIVUM, Plant Physiology and Biochemistry, 25(3), 283-289, Croy, RRD., Lycett, GW., Gatehouse, JA., Evans, M., Shirsat, A., Levasseur, M., Boulter, D., (1985) THE LEGUMIN GENE FAMILY OF PEA, Journal of the Science of Food and Agriculture, 36(8), 658-658, Lycett, GW., Croy, RRD., Shirsat, AH., Richards, DM., Boulter, D., (1985) THE 5'-FLANKING REGIONS OF 3 PEA LEGUMIN GENES - COMPARISON OF THE DNA-SEQUENCES, Nucleic Acids Research, 13(18), 6733-6743, Lycett, GW., Croy, RRD., Delauney, AJ., Shirsat, AH., Boulter, D., (1984) MOLECULAR ANALYSIS OF THE GENE FAMILIES CODING FOR THE STORAGE PROTEINS OF PISUM-SATIVUM-L, Heredity, 53(DEC), 563-563, Lycett, GW., Croy, RRD., Shirsat, AH., Boulter, D., (1984) THE COMPLETE NUCLEOTIDE-SEQUENCE OF A LEGUMIN GENE FROM PEA (PISUM-SATIVUM-L), Nucleic Acids Research, 12(11), 4493-4506,