Mareque-Rivas, Juan - Swansea University

个人简介

My research is focused on how to design, synthesise, characterise, assemble, fabricate, operate and develop functional molecular systems (drug delivery vehicles, sensors, motors, actuators, and other molecule-based devices and machines) for different applications. I did my PhD in supramolecular chemistry at the University of Missouri-St Louis under the supervision of Lee Brammer and postdoctoral research in bioinorganic/bioorganic chemistry at MIT in the laboratory of Steve Lippard. I held posts at the EastCHEM School of Chemistry (Lecturer and Senior Lecturer) of the University of Edinburgh, the School of Engineering (Reader) of the University of Aberdeen, and The Centre for Cooperative Research in Biomaterials (CIC biomaGUNE) where I continue to be Ikerbasque Research Professor and Group Leader of the Theranostic Nanomedicine Laboratory. I have an interest in integrating chemical, biological and electronic functions; on how to mix molecular building blocks on a single platform; how to retain/enhance function in moving from solution to a surface and from bulk to the nanoscale; surface functionalization of nano- and microparticles and for devices; understanding and resolving the interference between building blocks; molecules, materials and systems that display stimuli-responsiveness. My lab seeks the development and screening of novel types of organised nano/microscale architectures that are spontaneously self-assembled from multiple components and which when combined together exert special (therapeutic, diagnostic, molecular recognition, sensing or catalytic) functions. An important current focus in the lab is the design, development and study of molecules and nanoparticle constructs for immunomodulation and cancer immunotherapy.

近期论文

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Ruggiero, E., Garino, C., Mareque-Rivas, J., Habtemariam, A. & Salassa, L. (2016). Upconverting Nanoparticles Prompt Remote Near-Infrared Photoactivation of Ru(II)-Arene Complexes. Chemistry - A European Journal 22(8), 2801-2811. https://cronfa.swan.ac.uk/Record/cronfa30763 doi:10.1002/chem.201503991 Ruiz-de-Angulo, A., Zabaleta, A., Gómez-Vallejo, V., Llop, J. & Mareque-Rivas, J. (2016). Microdosed Lipid-Coated67Ga-Magnetite Enhances Antigen-Specific Immunity by Image Tracked Delivery of Antigen and CpG to Lymph Nodes. ACS Nano 10(1), 1602-1618. https://cronfa.swan.ac.uk/Record/cronfa30761 doi:10.1021/acsnano.5b07253 (2015). An Iron Oxide Nanocarrier Loaded with a Pt(IV) Prodrug and Immunostimulatory dsRNA for Combining Complementary Cancer Killing Effects. Advanced Healthcare Materials 4(7), 1034-1042. https://cronfa.swan.ac.uk/Record/cronfa30762 doi:10.1002/adhm.201500080 (2015). Near infrared activation of an anticancer PtIVcomplex by Tm-doped upconversion nanoparticles. Chem. Commun. 51(11), 2091-2094. https://cronfa.swan.ac.uk/Record/cronfa30764 doi:10.1039/C4CC07960D (2015). Enhanced cancer cell killing of a Pt(iv) prodrug promoted by outer-sphere coordination with polyethyleneimines. Dalton Trans. 44(16), 7135-7138. https://cronfa.swan.ac.uk/Record/cronfa30766 doi:10.1039/C5DT00175G (2014). Near infrared photolysis of a Ru polypyridyl complex by upconverting nanoparticles. Chemical Communications 50(14), 1715 https://cronfa.swan.ac.uk/Record/cronfa30778 doi:10.1039/C3CC47601D (2014). Quantum Dot Photoactivation of Pt(IV) Anticancer Agents: Evidence of an Electron Transfer Mechanism Driven by Electronic Coupling. The Journal of Physical Chemistry C 118(16), 8712-8721. https://cronfa.swan.ac.uk/Record/cronfa30777 doi:10.1021/jp501447q (2014). Two Novel Ternary Dicopper(II) μ-Guanazole Complexes with Aromatic Amines Strongly Activated by Quantum Dots for DNA Cleavage. Inorganic Chemistry 53(1), 578-593. https://cronfa.swan.ac.uk/Record/cronfa30769 doi:10.1021/ic4027249 (2014). An Iron Oxide Nanocarrier for dsRNA to Target Lymph Nodes and Strongly Activate Cells of the Immune System. Small, n/a-n/a. https://cronfa.swan.ac.uk/Record/cronfa30767 doi:10.1002/smll.201401353 (2014). Light Harvesting and Photoemission by Nanoparticles for Photodynamic Therapy. Particle & Particle Systems Characterization 31(1), 46-75. https://cronfa.swan.ac.uk/Record/cronfa30770 doi:10.1002/ppsc.201300314 (2013). A dinucleating ligand which promotes DNA cleavage with one and without a transition metal ion. Chemical Communications 49(35), 3655 https://cronfa.swan.ac.uk/Record/cronfa30773 doi:10.1039/C3CC39067E (2013). Nano-functionalization of metal complexes for molecular imaging and anticancer therapy. Coordination Chemistry Reviews 257(19-20), 2668-2688. https://cronfa.swan.ac.uk/Record/cronfa30771 doi:10.1016/j.ccr.2013.04.014