Loveridge, Joel - Swansea University - Department of Chemistry

个人简介

Following an MSci in Chemistry with Industrial Experience and a PhD in Biological Chemistry from the University of Bristol, I undertook postdoctoral positions at Cardiff University and Swansea University, before becoming Lecturer in NMR Spectroscopy in Cardiff University in 2012. I moved to Swansea as Senior Lecturer in Chemistry in 2016, to be part of the exciting new Department of Chemistry. My main focus at present is the development of an innovative chemistry curriculum that best serves our students. I have a Postgraduate Certificate in University Teaching and Learning, am a Fellow of the Higher Education Academy, and see my role as supporting students’ learning rather than simply teaching. Inclusion of problem-based and active learning approaches are essential to best prepare students for life after university, in whatever sector they choose. My research focuses on two overlapping areas: The first is the relationship between the structure, dynamics and function of enzymes, as a route to understanding and controlling nature’s chemistry. This work involves multidimensional, multinuclear NMR spectroscopy in conjunction with other biophysical techniques such as UV-visible spectroscopy. The second is natural products biosynthesis, particularly involving compounds with antibiotic, antifungal, or other medically relevant activity. This work uses a range of microbiological, genetic, biochemical and spectroscopic methods to study and manipulate the biosynthesis and activity of the target compounds. Expressions of interest in my research from prospective PhD students are always welcome. I am a member of the Royal Society of Chemistry (RSC) and the Biochemical Society, and am currently Chairman of the RSC South Wales West Local Section. I am heavily involved in public engagement and outreach. I organise the RSC South Wales West Local Section’s highly successful Science and Energy demonstration series, and have been involved in a wide range of other outreach events. Start Date End Date Position Held Location 2016 Present Senior Lecturer in Chemistry Department of Chemistry, Swansea University 2012 2016 Lecturer in NMR Spectroscopy School of Chemistry, Cardiff University 2011 2012 Research Officer College of Medicine, Swansea University 2010 2011 Research Associate School of Chemistry, Cardiff University 2007 2010 Postdoctoral Research Assistant School of Chemistry, Cardiff University 2003 2006 PhD in Chemistry (supervisor Dr John Crosby) School of Chemistry, University of Bristol 1999 2003 MSci in Chemistry with Industrial Experience School of Chemistry, University of Bristol

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Ruiz-Pernia, J., Behiry, E., Luk, L., Loveridge, E., Tunon, I., Moliner, V. & Allemann, R. (2016). Minimization of dynamic effects in the evolution of dihydrofolate reductase. Chem. Sci. 7(5), 3248-3255. https://cronfa.swan.ac.uk/Record/cronfa29960 doi:10.1039/c5sc04209g Loveridge, E. & Allemann, R. (2016). Pinpointing dynamic coupling in enzymes for efficient drug design. Future Science OA 2(1) https://cronfa.swan.ac.uk/Record/cronfa29961 doi:10.4155/fsoa.2015.0017 Luk, L., Ruiz-Pernia, J., Adesina, A., Loveridge, E., Tunon, I., Moliner, V. & Allemann, R. (2015). Chemical Ligation and Isotope Labeling to Locate Dynamic Effects during Catalysis by Dihydrofolate Reductase. Angewandte Chemie International Edition 54(31), 9016-9020. https://cronfa.swan.ac.uk/Record/cronfa29962 doi:10.1002/anie.201503968 Luk, L., Loveridge, E. & Allemann, R. (2015). Protein motions and dynamic effects in enzyme catalysis. Phys. Chem. Chem. Phys. 17(46), 30817-30827. https://cronfa.swan.ac.uk/Record/cronfa29963 doi:10.1039/c5cp00794a Luk, L., Javier Ruiz-Pernia, J., Dawson, W., Loveridge, E., Tunon, I., Moliner, V. & Allemann, R. (2014). Protein Isotope Effects in Dihydrofolate Reductase FromGeobacillus stearothermophilusShow Entropic–Enthalpic Compensatory Effects on the Rate Constant. Journal of the American Chemical Society 136(49), 17317-17323. https://cronfa.swan.ac.uk/Record/cronfa29969 doi:10.1021/ja5102536 Behiry, E., Luk, L., Matthews, S., Loveridge, E. & Allemann, R. (2014). Role of the Occluded Conformation in Bacterial Dihydrofolate Reductases. Biochemistry 53(29), 4761-4768. https://cronfa.swan.ac.uk/Record/cronfa29970 doi:10.1021/bi500507v Guo, J., Luk, L., Loveridge, E. & Allemann, R. (2014). Thermal Adaptation of Dihydrofolate Reductase from the Moderate ThermophileGeobacillus stearothermophilus. Biochemistry 53(17), 2855-2863. https://cronfa.swan.ac.uk/Record/cronfa29971 doi:10.1021/bi500238q Moody, S. & Loveridge, E. (2014). CYP105-diverse structures, functions and roles in an intriguing family of enzymes inStreptomyces. Journal of Applied Microbiology 117(6), 1549-1563. https://cronfa.swan.ac.uk/Record/cronfa29964 doi:10.1111/jam.12662 Hull, C., Loveridge, E., Donnison, I., Kelly, D. & Kelly, S. (2014). Co-production of bioethanol and probiotic yeast biomass from agricultural feedstock: application of the rural biorefinery concept. AMB Express 4(1) https://cronfa.swan.ac.uk/Record/cronfa29965 doi:10.1186/s13568-014-0064-5 Hull, C., Loveridge, E., Rolley, N., Donnison, I., Kelly, S. & Kelly, D. (2014). Co-production of ethanol and squalene using a Saccharomyces cerevisiae ERG1 (squalene epoxidase) mutant and agro-industrial feedstock. Biotechnology for Biofuels 7(1) https://cronfa.swan.ac.uk/Record/cronfa29966 doi:10.1186/s13068-014-0133-7 Luk, L., Loveridge, E. & Allemann, R. (2014). Different Dynamical Effects in Mesophilic and Hyperthermophilic Dihydrofolate Reductases. Journal of the American Chemical Society 136(19), 6862-6865. https://cronfa.swan.ac.uk/Record/cronfa29967 doi:10.1021/ja502673h Behiry, E., Evans, R., Guo, J., Loveridge, E. & Allemann, R. (2014). Loop Interactions during Catalysis by Dihydrofolate Reductase fromMoritella profunda. Biochemistry 53(29), 4769-4774. https://cronfa.swan.ac.uk/Record/cronfa29968 doi:10.1021/bi500508z Loveridge, E., Matthews, S., Williams, C., Whittaker, S., Guenther, U., Evans, R., Dawson, W., Crump, M. & Allemann, R. (2013). Aliphatic 1H, 13C and 15N chemical shift assignments of dihydrofolate reductase from the psychropiezophile Moritella profunda in complex with NADP+ and folate. Biomolecular NMR Assignments 7(1), 61-64. https://cronfa.swan.ac.uk/Record/cronfa29972 doi:10.1007/s12104-012-9378-x