个人简介

BS Southwest Missouri State University, 1981 PhD University of California at Berkeley, 1991 Postdoctoral Associate, Harvard Medical School, 1991-1993 Assistant Professor of Chemistry, University of Virginia, 1993-2000 Associate Professor of Chemistry, Virginia Tech, 2000-2009 Professor of Chemistry, Virginia Tech, 2009-present

研究领域

Chemical Biology/Medicinal

The three-dimensional structures of proteins have an inherent beauty. We explore the structure and function of proteins by designing and synthesizing mimics of peptides, a process of sculpture on the molecular level. We design the organic molecules using computers, and synthesize each one using stereoselective reactions. We make peptide mimics to constrain biopolymers inspired by the structural protein, collagen. Pin1 is an enzyme that regulates cell signaling in a wide range of disease states. We make inhibitors of Pin1, and investigate the potential of these compounds to fight a variety of cancers, asthma, diabetes, cocaine addiction, and Alzheimer’s diseases.

近期论文

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Felicia A. Etzkorn and Song Zhao, Stereospecific Phosphorylation by the Central Mitotic Kinase Cdk1-cyclin B, ACS Chem Biol, Special Issue: New Frontiers in Kinases 2015, 10, doi: http://pubs.acs.org/doi/abs/10.1021/cb500815b Mercedes-Camacho, A. Y.; Mullins, A. B.; Mason, M. D.; Xu, G. G.; Mahoney, B. J.; Wang, X.; Peng, J. W.; Etzkorn, F. A. Kinetic isotope effects support the twisted amide mechanism of Pin1 peptidyl-prolyl isomerase, Biochemistry 2013, 52, 7707-7713. doi: 10.1021/bi400700b. Zhang, M.; Wang, X. J.; Chen, X.; Bowman, M. E.; Luo, Y.; Noel, J. P.; Ellington, A. D.; Etzkorn, F. A.; Zhang, Y. Structural and kinetic analysis of prolyl-isomerization/phosphorylation cross-talk in the CTD code, ACS Chem Biol 2012, 7, 1462-1470. doi:10.1021/cb3000887. Xu, G. G.; Slebodnick, C.; Etzkorn, F. A. Cyclohexyl ketone inhibitors of Pin1 dock in a trans-diaxial cyclohexane conformation, PLoS One 2012, 7, e44226. doi: 10.1371/journal.pone.0044226. Xu, G. G.; Zhang, Y.; Mercedes-Camacho, A. Y.; Etzkorn, F. A. A reduced-amide inhibitor of Pin1 binds in a conformation resembling a twisted-amide transition state, Biochemistry 2011, 50, 9545-9550. doi: 10.1021/bi201055c.