Eastwood, Dan - Swansea University - Department of Biosciences

个人简介

I am interested in understanding how higher fungi grow, exploit resources in their environment and make mushrooms. I mainly employ molecular tools (genomics, transcriptomics, proteomics) in my research combined with traditional microbiological and biochemical analysis. I have been involved in many genome research programmes of saprotrophic wood decay fungi working closely with the Joint Genome Institute, Walnut Creek, California, and led the dry rot fungus (Serpula lacrymans) sequencing project. The main findings have focused on the evolution of wood decay mechanisms, particularly the convergent evolution of the brown rot decay mode. My current research uses genome sequenced saprotrophs to study the interaction between competing fungi during wood decay, considering the succession from primary through to tertiary decomposers and how environmental change might affect these processes. I have worked extensively with the cultivated button mushroom, Agaricus bisporus, investigating mushroom development in response to environmental triggers, regulation of postharvest quality, flavour development and controlling mushroom virus X disease. I built on this expertise to assess the potential of wood decay fungi in a novel low input biorefinery model to generate high value chemical products from lignin decomposition. I also supervise research students investigating the control of invasive plants, particularly Japanese knotweed, and the interaction between rare sand dune-inhabiting orchid species and rhizosphere microorganisms. Since joining Swansea University, I have enjoyed working with colleagues on diverse projects from the mechanisms of killing by entomopathogenic fungi, fish transcriptomics and diseases of crustaceans. Areas of Expertise Fungal Biology Genomics Molecular Biology Transcriptomics Agaricus bisporus Serpula lacrymans Wood decomposition Biofuels and biorefineries Start Date End Date Position Held Location 2012 Present Senior lecturer Swansea University 2011 2012 Lead Tutor APT Bioscience Swansea University 2008 2011 Senior research fellow University of Warwick 2004 2008 Postdoctoral research fellow University of Warwick 1998 2003 Postdoctoral research fellow at Horticulture Research Int. Wellesbourne, Warwickshire 1993 1997 Ph.D. Environmental Microbiology University of Liverpool 1991 1993 First Class B.Sc. (Hons.) Microbiology University of Liverpool

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Eastwood, D., Green, J., Grogan, H., Burton, K. & Cullen, D. (2015). Viral Agents Causing Brown Cap Mushroom Disease of Agaricus bisporus. Applied and Environmental Microbiology 81(20), 7125-7134. https://cronfa.swan.ac.uk/Record/cronfa23549 doi:10.1128/AEM.01093-15 Folch-Mallol, J., Butt, T., Greenfield, B., Greig, C., Maffeis, T., Taylor, J., Piasecka, J., Dudley, E., Abdulla, A., Dubovskiy, I., Garrido-Jurado, I., Quesada-Moraga, E., Penny, M. & Eastwood, D. (2013). Metarhizium anisopliae Pathogenesis of Mosquito Larvae: A Verdict of Accidental Death. PLoS ONE 8(12), e81686 https://cronfa.swan.ac.uk/Record/cronfa30740 doi:10.1371/journal.pone.0081686 Eastwood, D. Herman, B. Noble, R. Dobrovin-Pennington, A. Sreenivasaprasad, S. & Burton, K. (2013). Environmental regulation of reproductive phase change in Agaricus bisporus by 1-octen-3-ol, temperature and CO2. Fungal Genetics and Biology 55, 54-66. https://cronfa.swan.ac.uk/Record/cronfa16461 doi:10.1016/j.fgb.2013.01.001 Patyshakuliyeva, A. Jurak, E. Kohler, A. Baker, A. Battaglia, E. Bruijn, W. Burton, K. Challen, M. Coutinho, P. Eastwood, D. Gruben, B. Mäkelä, M. Martin, F. Nadal, M. Brink, J. Wiebenga, A. Zhou, M. Henrissat, B. Kabel, M. Gruppen, H. & Vries, R. (2013). Carbohydrate utilization and metabolism is highly differentiated in Agaricus bisporus. BMC Genomics 14(1), 663 https://cronfa.swan.ac.uk/Record/cronfa16462 doi:10.1186/1471-2164-14-663 Smith, A. Hamilton, K. Hirschle, L. Wootton, E. Vogan, C. Pope, E. Eastwood, D. & Rowley, A. (2013). Characterization and Molecular Epidemiology of a Fungal Infection of Edible Crabs (Cancer pagurus) and Interaction of the Fungus with the Dinoflagellate Parasite Hematodinium. Applied and Environmental Microbiology 79(3), 783-793. https://cronfa.swan.ac.uk/Record/cronfa16460 doi:10.1128/AEM.02945-12 Koncsag, C. Eastwood, D. Collis, A. Coles, S. Clark, A. Kirwan, K. & Burton, K. (2012). Extracting valuable compounds from straw degraded by Pleurotus ostreatus. Resources, Conservation and Recycling 59, 14-22. https://cronfa.swan.ac.uk/Record/cronfa16463 doi:10.1016/j.resconrec.2011.04.007 Fernandez-Fueyo, E. Ruiz-Duenas, F. Ferreira, P. Floudas, D. Hibbett, D. Canessa, P. Larrondo, L. James, T. Seelenfreund, D. Lobos, S. Polanco, R. Tello, M. Honda, Y. Watanabe, T. Watanabe, T. Ryu, J. Kubicek, C. Schmoll, M. Gaskell, J. Hammel, K. John, F. Wymelenberg, A. Sabat, G. BonDurant, S. Syed, K. Yadav, J. Doddapaneni, H. Subramanian, V. Lavin, J. (2012). Comparative genomics of Ceriporiopsis subvermispora and Phanerochaete chrysosporium provide insight into selective ligninolysis. Proceedings of the National Academy of Sciences 109(14), 5458-5463. https://cronfa.swan.ac.uk/Record/cronfa14078 doi:10.1073/pnas.1119912109 Floudas, D. Binder, M. Riley, R. Barry, K. Blanchette, R. Henrissat, B. Martinez, A. Otillar, R. Spatafora, J. Yadav, J. Aerts, A. Benoit, I. Boyd, A. Carlson, A. Copeland, A. Coutinho, P. Vries, R. Ferreira, P. Findley, K. Foster, B. Gaskell, J. Glotzer, D. Gorecki, P. Heitman, J. Hesse, C. Hori, C. Igarashi, K. Jurgens, J. Kallen, N. (2012). The Paleozoic Origin of Enzymatic Lignin Decomposition Reconstructed from 31 Fungal Genomes. Science 336(6089), 1715-1719. https://cronfa.swan.ac.uk/Record/cronfa14079 doi:10.1126/science.1221748 Morin, E. Kohler, A. Baker, A. Foulongne-Oriol, M. Lombard, V. Nagy, L. Ohm, R. Patyshakuliyeva, A. Brun, A. Aerts, A. Bailey, A. Billette, C. Coutinho, P. Deakin, G. Doddapaneni, H. Floudas, D. Grimwood, J. Hilden, K. Kues, U. LaButti, K. Lapidus, A. Lindquist, E. Lucas, S. Murat, C. Riley, R. Salamov, A. Schmutz, J. Subramanian, V. Wosten, H. (2012). Genome sequence of the button mushroom Agaricus bisporus reveals mechanisms governing adaptation to a humic-rich ecological niche. Proceedings of the National Academy of Sciences 109(43), 17501-17506. https://cronfa.swan.ac.uk/Record/cronfa14081 doi:10.1073/pnas.1206847109 Eastwood, D. (2011). Genome Organization and Transcription Response to Harvest of Two. Journal of Microbiology and Biotechnology 21(5), 455-463. https://cronfa.swan.ac.uk/Record/cronfa16465 doi:10.4014/jmb.1007.07031 Koncsag, C. Eastwood, D. & Kirwan, K. (2011). Recovering low molecular weight extractives from degraded straw by oyster mushroom at the farm scale for high value use. Biomass and Bioenergy 35(7), 3276-3279. https://cronfa.swan.ac.uk/Record/cronfa16467 doi:10.1016/j.biombioe.2011.04.051 Eastwood, D. Floudas, D. Binder, M. Majcherczyk, A. Schneider, P. Aerts, A. Asiegbu, F. Baker, S. Barry, K. Bendiksby, M. Blumentritt, M. Coutinho, P. Cullen, D. Vries, R. Gathman, A. Goodell, B. Henrissat, B. Ihrmark, K. Kauserud, H. Kohler, A. LaButti, K. Lapidus, A. Lavin, J. Lee, Y. Lindquist, E. Lilly, W. Lucas, S. Morin, E. Murat, C. (2011). The Plant Cell Wall-Decomposing Machinery Underlies the Functional Diversity of Forest Fungi. Science 333(6043), 762-765. https://cronfa.swan.ac.uk/Record/cronfa14082 doi:10.1126/science.1205411