钟龙华 - 南方科技大学

个人简介

钟龙华博士(博导，独立课题组组长)，分别在00、03和06年获得香港科技大学一级荣誉学士、硕士和博士学位，师从吴云东院士，研究(贵金属和主族金属)金属催化有机反应机理。06-13年到京都大学福井謙一記念研究中心諸熊奎治(Keiji Morokuma)院士组，采用和发展多尺度模拟方法研究复杂生物体系。13年10月起加入南方科技大学化学系(预聘助理教授)，18年2月(破格)晋升预聘副教授，21年7月(破格)晋升长聘正教授。在国外期刊上发表95篇SCI论文(包括1篇Chem. Rev. 2篇Acc. Chem. Res. 21篇J. Am. Chem. Soc.，1篇Wiley跨学科综述，6篇Angew. Chem. Int. Ed.，5篇Nat. Commun., 7篇Chem. Sci.，5篇ACS Catal., 5篇J. Phys. Chem., 5篇J. Chem. Theory Comput., 5篇Org. Lett., 3篇Chem. Commun., 3篇Inorg. Chem.)和3篇Wiley书籍章节。Web of Science引用>4400次（他引>4300次），H-index: 40。入选了斯坦福大学发布的2021年，2022年和2023年的全球前2％顶尖科学家。 Education: 1. 2006 Ph.D. in Chemistry, The Hong Kong University of Science & Technology (Supervisor: Prof. Yun-Dong Wu). Thesis: “Computational Studies of the Reaction Mechanisms and Stereochemistry of Metal-Mediated Organic Reactions” 2. 2003 M. Phil. in Chemistry, The Hong Kong University of Science & Technology (Supervisor: Prof. Yun-Dong Wu). Thesis: “Theoretical Studies on Organometallic Reaction in Water and Mechanism and Stereochemistry of Hydrosilylation and Hydroacylation Reactions” 3. 2000 B. Sc. in Chemistry (1st Hon.), The Hong Kong University of Science & Technology. (GGA: A) Academic Experience: 1. 2021 Jul-present Researcher/Full Professor (with tenure), Department of Chemistry, Southern University of Science and Technology 2. 2018 Feb-2021 Jun Researcher/Associate Professor (tenure-track), Department of Chemistry, Southern University of Science and Technology (early promotion) 3. 2013 Oct-2018 Jan Associate Researcher/Assistant Professor (tenure-track), Department of Chemistry, Southern University of Science and Technology 4. 2006-2013 Postdoctoral Fellow, Fukui Institute for Fundamental Chemistry, Kyoto University (Advisor: Prof. Keiji Morokuma) 5. June-July 1999 Research Assistant, Department of Chemistry, The University of Hong Kong (Supervisor: Dr. Tao Ye) Awards or Recognization: 8. 2023 World's Top 2% Scientis, 2023 8. 2022 World's Top 2% Scientists, 2022 7. 2021 World's Top 2% Scientists, 2021 6. 2014 Overseas High-Caliber Personnel from Shenzhen: Peacock Plan Awardee 5. 2006-2010 Fukui Fellowship 4. M.Phil. & Ph.D. Postgraduate Studentship 3. 2000 The Hong Kong University of Science and Technology Academic Achievement Medal Swire University Scholarship 2. 1997-2000 Swire University Scholarship 1. 1997-2000 Dean's List

研究领域

从事多尺度和机器学习模拟研究复杂均相催化化学和生物化学体系，包括生物与仿生催化反应机理，可持续化学反应机理，和新模拟方法的发展及应用

近期论文

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Yan, Z.; Wei, D.; Li, X.; Chung, L. W.* “Accelerating Reliable Multiscale Quantum Refinement of Protein–Drug Systems Enabled by Machine Learning” Nat. Commun. 2024, 15, 4181. Li, F.; Lan, J.; Li, X.;* Chung, L. W.* “A Synergistic Bimetallic Ti/Co-Catalyzed Isomerization of Epoxides to Allylic Alcohols Enabled by Two-State Reactivity” Inorg. Chem. 2024, DOI: 10.1021/acs.inorgchem.4c00011. Shum, M. H.-H.; Lee, Y.; Tam, L.; Xia, H.; Chung, O. L.-W.; Guo, Z.; Lam, T. T.-Y.,* “Binding affinity between coronavirus spike protein and human ACE2 receptor” Comput. Struct. Biotechnol. J. 2024, 23, 759. Lv, N.; Han, J.-C.; Zhang, P.; Huang, Y.-R.; Xu, Z.-X.; Xu, K.; Wang, X.-F.; Li, X.; Chung, L. W.; Li, C.-C.* “Asymmetric Total Synthesis of β-Funebrene with a Highly Strained Trans-fused [5-5] Rings by an Intramolecular [3+2] Annulation of Allenylsilane-ene” CHEM, 2024, 10, 190. Cheng, X.;# Chang, X.;# Yang, Y.;# Zhang, Z.; Li, J.; Li, Y.; Zhao, W.; Chung, L. W.;* Teng, H.; Dong, X.-Q; Wang, C.-J.* “Copper-Catalyzed Asymmetric 1,3-Dipolar Cycloaddition of Azomethine Ylides with β-Trifluoromethyl-Substituted Alkenyl Heteroarenes” Sci. Chin. Chem. 2023, 66, 3193. Liang, R.;# Zhou, Q.;# Li, X.;* Wong, M. W.;* Chung, L. W.,* “A Computational Study on the Reaction Mechanism of Stereo-controlled Synthesis of -Lactam within [2]Rotaxane” J. Org. Chem. 2023, 88, 10460. Chang, X.;# Liu, X.-T.;# Li, F.;# Yang, Y.; Chung, L. W.;* Wang, C.-J.* “Electron-Rich Benzofulvenes as Effective Dipolarophiles in Cop-per(I)-Catalyzed Asymmetric 1,3-Dipolar Cycloaddition of Azome-thine Ylides” Chem. Sci. 2023, 14, 5460. Zhou, M.;# Lin, Y.;# Chen, X.-X.;# Xu, G.;* Chung, L. W.,* Tang, W.-J.* “Asymmetric Synthesis of Vicinal Tetrasubstituted Diamines via Reductive Coupling of Ketimines Templated by Chiral Diborons” Angew. Chem. Int. Ed. 2023, 62, e202300334. Ma, F.;# Yan, Z.;# Li, X.;* Chung, L. W.* “Quantum Tunneling in Reactions Modulated by External Electric Fields: Reactivity and Selectivity” J. Phys. Chem. Lett. 2023, 14, 1124. Zheng, F.;# Yang, Y.;# Wu, S.; Zhao, S.; Zhu, Y.; Su, H.; Dai, J.-F.; Yan, Z.; Chung, L. W.* Wong, K. M.-C.* “Structure-property relationships of photofunctional diiridium(II) complexes with tetracationic charge and an unsupported Ir–Ir bond” Commun. Chem. 2022, 5, 159. Qin, C.;# Huang, Z.;# Wu, S.-B.;# Li, Z.; Yang, Y.; Xu, S.; Zhang, X.; Liu, G.; Wu, Y.-.D.; Chung, L. W.;* Huang, Z.* “Breaking Conventional Site Selectivity in C−H Bond Activation: Selective sp3 versus sp2 Silylation by a Pincer-Based Pocket” J. Am. Chem. Soc. 2022, 144, 20903. Lan, J.; Zhang, T.; Yang, Y.; Li, X.;* Chung, L. W.* “A Mechanistic Study of the Cobalt(I)-Catalyzed Amination of Aryl 2 Halides: Effects of Metal and Ligand” Inorg. Chem. 2022, 61, 18019. Wang, T.-Y.;# Chen, X.-X.;# Zhu, D.-X. Chung, L. W.; Xu, M.-H.* “Rhodium(I) Carbene-Promoted Enantioselective C-H Functionalization of Simple Unprotected Indoles, Pyrroles and Heteroanalogues: New Mechanistic Insights” Angew. Chem. Int. Ed. 2022, 61, e202207008. Liu, G.;# Zheng, L.;# Tian, K.; Wang, H.; Chung, L. W.; Zhang, X.;* Dong, X.-Q.* “Ir-Catalyzed Asymmetric Hydrogenation of Unprotected Indoles: Scope Investigations and Mechanistic Studies” CCS Chem. 2023, 5, 1398. Lan, J.;# Li, X.;# Yang, Y.; Zhang, X.; Chung, L. W.* “New Insights and Predictions into Complex Homogeneous Reactions Enabled by Computational Chemistry in Synergy with Experiments: Isotopes and Mechanisms” Acc. Chem. Res. 2022, 55, 1109. Wang, Q.;# Lan, J.;# Liang, R.; Xia, Y.; Qin, L.;* Chung, L. W.* Zheng, Z.* “New Tricks for an Old Dog: Grubbs Catalysts Enable Efficient Hydrogen Production from Aqueous-Phase Methanol Reforming” ACS Catal. 2022, 12, 2212. Yan, Z.; Li, X.; Chung, L. W.* “Multiscale Quantum Refinement Methods for Metalloproteins” J. Chem. Theory Comput. 2021, 17, 3783. Fan, X.; Zheng, L.; Yang, Y.; Dong, X.-Q.;* Zhang, X.; Chung, L. W.* “A Computational Study of Asymmetric Hydrogenation of 2-Phenyl Acrylic Acids Catalyzed by a Rh(I) Catalyst with Ferrocenyl Chiral Bisphosphorus Ligand: The Role of Ion-pair Interaction” Chin. J. Chem. 2021, 39, 1616 (An invited contribution to Department of Chemistry, SUSTech, on the Occasion of Her 10th Anniversary). Du, X.#; Xiao, Y.#; Yang, Y.#; Duan, Y.-N.; Li, F.; Hu, Q.; Chung, L. W.*; Chen, G.-Q.;* Zhang, X.* “Enantioselective Hydrogenation of tetra-Substituted α,β-Unsaturated Carboxylic Acids Enabled by Cobalt(II) Catalysis: Scope and Mechanistic Insights” Angew. Chem. Int. Ed. 2021, 60, 11384. Chang, X.#; Yang, Y.#; Shen, C.; Xue, K.-S.; Wang, Z.-F.; Tao, H.-Y.; Chung, L. W.;* Wang, C.-J.* “beta-Substituted Alkenyl Heteroarenes as Dipolarophiles in Cu(I)-Catalyzed Asymmetric 1,3-Dipolar Cycloaddition of Azomethine Ylides Empowered by Dual Activation Strategy: Stereoselectivity and Mechanistic Insight” J. Am. Chem. Soc. 2021, 143, 3519. Zhu, D.-X.#; Xia, H.#; Liu, J.-G.; Chung, L. W.*; Xu, M.-H.* “Regiospecific and Enantioselective Arylvinylcarbene Insertion of a C-H bond of Aniline Derivatives Enabled by a Rh(I)-Diene Catalyst” J. Am. Chem. Soc. 2021, 143, 2608. Fan, J.-H. Wang, J.-J.; Li, F.; Wang, G.; Guo, Q.; Chung, L. W.; Li, C.-C.* “Asymmetric Total Synthesis of Phomarol” CCS Chem. 2021, 3, 348. Chen, J.-P.; Li, Y.; Liu, C.; Chung, L. W.; Xu, M.-H.* "Water as a Direct Proton Source for Asymmetric Hydroarylation Catalyzed by a Rh(I)-Diene: Access to Nonproteinogenic β2/γ2/δ2-Amino Acid Derivatives” Org. Lett. 2021, 23, 571. Li, F.; Chung, L. W.* “AgN3-Catalyzed Hydroazidation of Terminal Alkynes and Mechanistic Studies” Chin. J. Org. Chem. (Highlight) 2020, 40, 2603. Feng, Q.; Wu, H.; Li, X.; Song, L.; Chung, L. W.* Wu, Y.-D.;* Sun, J.* “Ru-Catalyzed Geminal Hydroboration of Silyl Alkynes via a New gem-Addition Mechanism” J. Am. Chem. Soc. 2020, 142, 13867. Zhang, X.; Wu, S.-B., Leng, X.; Chung, L. W.; Liu, G.; Huang, Z.* “N-Bridged Pincer Iridium Complexes for Highly Efficient Alkane Dehydrogenation and the Relevant Linker Effects” ACS Catal. 2020, 10, 6475. Yang, Y.#; Zhang, X.#; Zhong, L.; Lan, J.; Li, X.; Li, C.-C.; Chung, L. W.* “Unusual KIE and Dynamics Effects in the Fe-catalyzed Hetero-Diels-Alder Reaction of Unactivated Aldehydes and Dienes” Nat. Commun. 2020, 11, 1850. Sun, X.-S.#; Ou-Yang, Q.#(Undergraduate); Wang, X.-H.; Shen, C.; Tao, H.-Y.; Chung, L. W.;* Wang, C.-J.* “Asymmetric Synthesis of Quaternary -Trifluoromethyl -Amino Acids by Ir-Catalyzed Allylation followed by Kinetic Resolution” Chem. Commun. 2020, 56, 3333. Song, L.#; Feng, Q.#, Wang, Y.; Ding, S.; Wu, Y.-D.; Zhang, Z.; Chung, L. W.;* Sun, J.* “Ru-Catalyzed Migratory Geminal SemiHydrogenation of Internal Alkynes to Terminal Olefins” J. Am. Chem. Soc. 2019, 141, 17441. Yang, Y.;* Zhou, Q.; Cai, J.; Xue, T.; Liu, Y.; Jiang, Y.; Su, Y.; Chung, L. W.;* Vicic, D. A.* “Exploiting the Trifluoroethyl Group as a Precatalyst Ligand in Nickel-catalyzed Suzuki-type Alkylations” Chem. Sci. 2019, 10, 5275. Deng, X.#; Shi, L.-Y.#; Lan, J.#; Guan, Y.-Q.; Zhang, X.; Lv, H.; Chung, L. W.;* Zhang, X.* “Enantioselective Rhodium-Catalyzed Cycloisomerization of 1,6-Allenynes to access 5/6-Fused Bicycle[4.3.0]nonadienes: An Experimental and Computational Study” Nat. Commun. 2019, 10, 949. Liu, X.; Liu, J.; Wu, J.; Huang, G.; Liang, R. (Undergraduate); Chung, L. W.; Li, C.-C.* “Asymmetric Total Synthesis of Cerorubenic Acid-III” J. Am. Chem. Soc. 2019, 141, 2872. Tu, B.; Shao, Y.; Chen, W.; Wu, Y.; Li, X.; He, Y.; Li, J.; Liu, F.; Zhang, Z.; Lin, Y.; Lan, X.; Xu, L.; Shi, X.; Ng, A. M. C.; Li, H.;* Chung, L. W.; Djurisic, A. B; He, Zhubing* “Novel Molecular Doping Mechanism for n-Doping of SnO2 via Triphenylphosphine Oxide and Its Effect on Perovskite Solar Cells” Adv. Mater. 2019, 31, 1805944. Wu, S.-B.#; Zhang, T.#; Chung, L. W.;* Wu, Y.-D. “A Missing Piece of the Mechanism in Metal-Catalyzed Hydrogenation: Co(-I)/Co(0)/Co(I) Catalytic Cycle for Co(-I)-Catalyzed Hydrogenation” Org. Lett. 2019, 21, 360. Shen, C.#; Yang, Y.#; Wei, L.; Dong, W. W.; Chung, L. W.;* Wang, C. J.* “Kinetic Resolution of Alkylidene Norcamphors via A Ligand-Controlled Umpolung-Type 1,3-Dipolar Cycloaddition” iScience 2019, 11, 146.