Dehmelt, Leif - Max Planck Institute of Molecular Physiology -

个人简介

Cellular and molecular processes in the functional and morphological differentiation of neurons play a key role in the development of the brain. Misregulation of those processes, for example due to aging, mutations or intake of toxic compounds, can lead to serious brain lesions. Thus, a better understanding of the underlying cellular and molecular mechanisms is central to a fundamental and holistic understanding of normal and perturbed brain development and function. In our lab, we study fundamental molecular and cellular processes in neuronal development and how those are affected by modulation of key cellular components. Our focus is on the cytoskeleton, as this cellular component plays a key role in defining the morphology and thereby the correct function of developing neurons. In earlier studies, we found that the main cyotoskeleton components, actin and microtubules, are coordinated with each other during the first formation of a neuronal protrusion. To understand this complex coordination of dynamic cellular components, we implement a systems biology approach that combines acute experimental perturbations, development of novel analysis technologies and mathematical modeling.

研究领域

Our research group studies the mechanisms, by which cells develop their complex shape. We are particularly focused on the mechanisms that underlie the self-organization of dynamic, fibrous structures that are collectively called the cytoskeleton (Video 1). To gain a better understanding how those structures are regulated in space and time, and how this affects cell shape, we are using a combination of screening technologies, acute chemical perturbation, live-cell imaging and computational modeling.

近期论文

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Chen X, Venkatachalapathy M, Kamps D, Weigel S, Kumar R, Orlich M, Garrecht R, Hirtz M, Niemeyer CM, Wu YW, Dehmelt L. (2017). "Molecular-Activity Painting": Switch-like, Light-Controlled Perturbations inside Living Cells. Angew Chem Int Ed Engl 21(14):5311-6. doi: 10.1002/anie.201611432 Arndt HD, Rizzo S, Nöcker C, Wakchaure VN, Milroy LG, Bieker V, Calderon A, Tran TT, Brand S,Dehmelt L, Waldmann H (2015). Divergent solid-phase synthesis of natural product-inspired bipartite cyclodepsipeptides: total synthesis of seragamide A. Chemistry 21(14):5311-6. doi: 10.1002/chem.201500368. Liu P, Calderon A, Konstantinidis G, Hou J, Voss S, Chen X, Li F, Banerjee S, Hoffmann JE, Theiss C, Dehmelt L, Wu YW (2014). A bioorthogonal small-molecule-switch system for controlling protein function in live cells. Angew Chem Int Ed Engl 53(38):10049-55. doi: 10.1002/anie.201403463. Dehmelt L (2014). Cytoskeletal self-organization in neuromorphogenesis. Bioarchitecture 4:75 (2014) doi: 10.4161/bioa.29070. Arrabito G, Schroeder H, Schröder K, Filips C, Marggraf U, Dopp C, Venkatachalapathy M, Dehmelt L, Bastiaens PI, Neyer A, Niemeyer CM (2014). Configurable low-cost plotter device for fabrication of multi-color sub-cellular scale microarrays. Small 10(14):2870-6. doi: 10.1002/smll.201303390. doi: 10.4161/bioa.29070. Mazel T, Biesemann A, Krejczy M, Nowald J, Müller O, Dehmelt L (2014). Direct observation of microtubule pushing by cortical dynein in living cells. Mol Biol Cell 25(1):95-106. doi: 10.1091/mbc.E13-07-0376. Schulze N, Graessl M, Blancke Soares A, Geyer M, Dehmelt L, Nalbant P (2014). FHOD1 regulates stress fiber organization by controlling the dynamics of transverse arcs and dorsal fibers. J Cell Sci 127(Pt 7):1379-93. doi: 10.1242/jcs.134627. doi: 10.1242/jcs.134627.