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刘刚博士多年来围绕高灵敏度、高特异性多功能分子影像探针的可控设计、构建及医学应用评价等方面开展研究工作,发展了一系列新型高灵敏的磁学、光学、光声分子影像探针,提高细胞、分子成像示踪监测的精确性;设计合成了新颖的诊疗一体化多功能纳米材料,探索无创靶向药物/基因治疗及实时影像监测;优化等离子光热/光动力协同治疗方法并增强治疗效果,为实现个体化医疗模式提供条件。作为项目负责人主持科技部重大专项课题、国家基金杰青、优青、重点、面上项目、青年基金项目及教育部科学技术研究重点项目等课题10余项(主持经费2千多万元)。2009年至今共发表SCI期刊论文200余篇(文章他引>18000次、H-index=75), 作为通讯/并列通讯作者在Nat Nano、PNAS、Nat Commun、Sci Adv、JACS、Adv Mater等国际知名杂志发表SCI论文80余篇,并连续多年入选科睿唯安(Clarivate)全球“高被引科学家”。副主编/编委参编教材4部,参编英文专著10余部并申报中国发明专利10余项(授权7项)。 2016.10--厦门大学特聘教授,博士生导师 2022.10--厦门大学公共卫生学院副院长 2021.03-2022.10厦门大学党委人才工作办公室副主任兼人事处副处长 2017.08-2020.03厦门大学科技处副处长(挂职) 2015.07-2016.10厦门大学教授,博士生导师 2013.12-2015.06厦门大学教授,硕士生导师 2012.12-2013.12厦门大学副教授,硕士生导师

研究领域

分子影像探针、生物医用高分子、药物/基因传输体系

近期论文

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Li S, Liu X, Liu G, Liu C. Biomimetic Nanotechnology for SARS-CoV-2 Treatment. Viruses. 2023 Feb 21;15(3):596. doi: 10.3390/v15030596. Li D, Cai S, Wang P, Cheng H, Cheng B, Zhang Y, Liu G. Innovative Design Strategies Advance Biomedical Applications of Phthalocyanines. Adv Healthc Mater. 2023 Apr 11:e2300263. doi: 10.1002/adhm.202300263. Zhang J, Xia Y, Liu X, Liu G. Advanced Vaccine Design Strategies against SARS-CoV-2 and Emerging Variants. Bioengineering (Basel). 2023 Jan 22;10(2):148. doi: 10.3390/bioengineering10020148. Xu D, Ge J, An Y, Bai S, Wang Z, Wu S, Dai Q, Lu Z, Liu G. Molecular Engineering of NIR-II/IIb Emitting AIEgen for Multimodal Imaging-Guided Photo-Immunotherapy. Small. 2023 Apr 17:e2300859. doi: 10.1002/smll.202300859. Lin G, Nash GT, Luo T, Ghosh I, Sohoni S, Christofferson AJ, Liu G, Engel GS, Lin W. 2D Nano-Sonosensitizers Facilitate Energy Transfer to Enhance Sonodynamic Therapy. Adv Mater. 2023 May;35(19):e2212069. doi: 10.1002/adma.202212069. Jiang L, Ding L, Liu G. Nanoparticle formulations for therapeutic delivery, pathogen imaging and theranostic applications in bacterial infections. Theranostics. 2023 Mar 5;13(5):1545-1570. doi: 10.7150/thno.82790. Liu X, Yuan L, Chen J, Zhang Y, Chen P, Zhou M, Xie J, Ma J, Zhang J, Wu K, Tang Q, Yuan Q, Zhu H, Cheng T, Guan Y, Liu G, Xia N. Antiviral Nanobiologic Therapy Remodulates Innate Immune Responses to Highly Pathogenic Coronavirus. Adv Sci (Weinh). 2023 Apr 25:e2207249. doi: 10.1002/advs.202207249. Wu S, Zhang J, Pan J, Bai S, Wang Z, Chen Y, Xu D, An Y, Liu C, Chu C, Dai Q, Jiang L, Lu Z, Liu G. Integrated Nanorod-Mediated PD-L1 Downregulation in Combination with Oxidative-Stress Immunogene Therapy against Cancer. Adv Healthc Mater. 2023 Feb 11:e2300110. doi: 10.1002/adhm.202300110. Lin G, Zhou J, Cheng H, Liu G. Smart Nanosystems for Overcoming Multiple Biological Barriers in Cancer Nanomedicines Transport: Design Principles, Progress, and Challenges. Small. 2023 Mar 27:e2207973. doi: 10.1002/smll.202207973. Liu Y, Rao P, Qian H, Shi Y, Chen S, Lan J, Mu D, Chen R, Zhang X, Deng C, Liu G, Shi G. Regulatory Fibroblast-Like Synoviocytes Cell Membrane Coated Nanoparticles: A Novel Targeted Therapy for Rheumatoid Arthritis. Adv Sci (Weinh). 2023 Feb;10(4):e2204998. doi: 10.1002/advs.202204998. Liu C, Liu X, Xiang X, Pang X, Chen S, Zhang Y, Ren E, Zhang L, Liu X, Lv P, Wang X, Luo W, Xia N, Chen X, Liu G. A nanovaccine for antigen self-presentation and immunosuppression reversal as a personalized cancer immunotherapy strategy. Nat Nanotechnol. 2022 May;17(5):531-540. doi: 10.1038/s41565-022-01098-0. Chen BQ, Zhao Y, Zhang Y, Pan YJ, Xia HY, Kankala RK, Wang SB, Liu G, Chen AZ. Immune-regulating camouflaged nanoplatforms: A promising strategy to improve cancer nano-immunotherapy. Bioact Mater. 2022 Aug 10;21:1-19. doi:10.1016/j.bioactmat.2022.07.023. Zhao Y, Mei Z, Luo X, Mao J, Zhao Q, Liu G, Wu D. Remote vascular interventional surgery robotics: a literature review. Quant Imaging Med Surg. 2022 Apr;12(4):2552-2574. doi: 10.21037/qims-21-792. Wu S, Liu C, Bai S, Lu Z, Liu G. Broadening the Horizons of RNA Delivery Strategies in Cancer Therapy. Bioengineering (Basel). 2022 Oct 19;9(10):576. doi: 10.3390/bioengineering9100576. Ma J, Jiang L, Liu G. Cell membrane-coated nanoparticles for the treatment of bacterial infection. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2022 Sep;14(5):e1825. doi: 10.1002/wnan.1825. Li L, Zeng Y, Chen M, Liu G. Application of Nanomicelles in Enhancing Bioavailability and Biological Efficacy of Bioactive Nutrients. Polymers (Basel). 2022 Aug 11;14(16):3278. doi: 10.3390/polym14163278. Chen B, Chu C, Ren E, Lin H, Zhang Y, Wang P, Yao H, Liu A, Liu G, Lin X. Metal Ion-Based Supramolecular Self-Assembly for Cancer Theranostics. Front Chem. 2022;10:870769. Yu YY, Shi XX, Xu SY, Ma XH, Wei RJ, Hou H, Chu CC, Sun D, Liu G, Tan YZ. Atomically Precise Water-Soluble Graphene Quantum Dot for Cancer Sonodynamic Therapy. Adv Sci (Weinh). 2022 (19):e2105034. Shi Y, Qian H, Rao P, Mu D, Liu Y, Liu G, Lin Z. Bioinspired membrane-based nanomodulators for immunotherapy of autoimmune and infectious diseases. Acta Pharm Sin B. 2022 (3):1126-1147. Liang X, Cheng H, Liu C, Liu G. Antigen self-presenting nanovaccine for cancer immunotherapy. Sci Bull (Beijing). 2022;67(16):1611-1613. Chen H, Zhang P, Shi Y, Liu C, Zhou Q, Zeng Y, Cheng H, Dai Q, Gao X, Wang X, Liu G. Functional nanovesicles displaying anti-PD-L1 antibodies for programmed photoimmunotherapy. J Nanobiotechnology. 2022 Feb 2;20(1):61. doi: 10.1186/s12951-022-01266-3. Mu D, He P, Shi Y, Jiang L, Liu G. Bioinspired Membrane-Coated Nanoplatform for Targeted Tumor Immunotherapy. Front Oncol. 2022 Jan 10;11:819817. doi: 10.3389/fonc.2021.819817. Bai S, Lan Y, Fu S, Cheng H, Lu Z, Liu G. Connecting Calcium-Based Nanomaterials and Cancer: From Diagnosis to Therapy. Nanomicro Lett. 2022 Jul 18;14(1):145. doi: 10.1007/s40820-022-00894-6. Cheng H, Fan X, Ye E, Chen H, Yang J, Ke L, You M, Liu M, Zhang YW, Wu YL, Liu G, Loh XJ, Li Z. Dual Tumor Microenvironment Remodeling by Glucose-Contained Radical Copolymer for MRI-Guided Photoimmunotherapy. Adv Mater. 2022 Jun;34(25):e2107674. doi: 10.1002/adma.202107674. Chen H, Cheng H, Liang X, Cai S, Liu G. Immunosuppression Reversal Nanovaccines Substituting Dendritic Cells for Personalized Cancer Immunotherapy. Front Immunol. 2022 Jun 24;13:934259. doi: 10.3389/fimmu.2022.934259. Xue Y, Bao W, Zhou J, Zhao QL, Hong SZ, Ren J, Yang BC, Wang P, Yin B, Chu CC, Liu G, Jia CY. Global Burden, Incidence and Disability-Adjusted Life-Years for Dermatitis: A Systematic Analysis Combined With Socioeconomic Development Status, 1990-2019. Front Cell Infect Microbiol. 2022 Apr 12;12:861053. doi: 10.3389/fcimb.2022.861053. Wang J, Liu G, Wáng YXJ. Transforming a clinical fluorescent dye to sense and treat iron overload disorders: a new reverse translational approach in precision medicine. Quant Imaging Med Surg. 2022 May;12(5):3020-3023. doi: 10.21037/qims-2022-01. He P, Ren E, Chen B, Chen H, Cheng H, Gao X, Liang X, Liu H, Li J, Li B, Chen A, Chu C, Chen X, Mao J, Zhang Y, Liu G. A super-stable homogeneous Lipiodol-hydrophilic chemodrug formulation for treatment of hepatocellular carcinoma. Theranostics. 2022 Jan 24;12(4):1769-1782. doi: 10.7150/thno.68456. Zhu J, Chu C, Li D, Zhang Y, Cheng Y, Lin H, Wang X, Liu J, Pang X, Cheng J, Liu G. Superior Fluorescent Nanoemulsion Illuminates Hepatocellular Carcinoma for Surgical Navigation. Front Bioeng Biotechnol. 2022 Apr 25;10:890668. doi: 10.3389/fbioe.2022.890668. He P, Xiong Y, Ye J, Chen B, Cheng H, Liu H, Zheng Y, Chu C, Mao J, Chen A, Zhang Y, Li J, Tian J, Liu G. A clinical trial of super-stable homogeneous lipiodol-nanoICG formulation-guided precise fluorescent laparoscopic hepatocellular carcinoma resection. J Nanobiotechnology. 2022 Jun 3;20(1):250. doi: 10.1186/s12951-022-01467-w. Li W, Liu G, Bao J, Dong S, Hu X, Yi X, Lin Z. Effects of the Interlayer Toughening Agent Structure on the Flow Behavior during the z-RTM Process. Materials (Basel). 2022 May 2;15(9):3265. doi: 10.3390/ma15093265. Xiong Y, He P, Zhang Y, Chen H, Peng Y, He P, Tian J, Cheng H, Liu G, Li J. Superstable homogeneous lipiodol-ICG formulation: initial feasibility and first-in-human clinical application for ruptured hepatocellular carcinoma. Regen Biomater. 2022 Dec 16;10:rbac106. doi: 10.1093/rb/rbac106. Lu Z, Bai S, Jiang Y, Wu S, Xu D, Zhang J, Peng X, Zhang H, Shi Y, Liu G. Amplifying Dendritic Cell Activation by Bioinspired Nanometal Organic Frameworks for Synergistic Sonoimmunotherapy. Small. 2022 Nov;18(44):e2203952. doi: 10.1002/smll.202203952. He P, Xiong Y, Luo B, Liu J, Zhang Y, Xiong Y, Su S, Fang C, Peng Y, Cheng H, Chu C, Mao J, Li J, Li B, Yin Z, Tian J, Liu G. An exploratory human study of superstable homogeneous lipiodol-indocyanine green formulation for precise surgical navigation in liver cancer. Bioeng Transl Med. 2022 Sep 10;8(2):e10404. doi: 10.1002/btm2.10404. Peng Y, He P, Gao X, Liu G, Cheng H. A Superstable Homogeneous Lipiodol-Nanoformulation to Overcome the Dilemma of Interventional Embolization Chemotherapy. Front Bioeng Biotechnol. 2022 Jun 21;10:952194. doi: 10.3389/fbioe.2022.952194. Dai Q, Wang L, Ren E, Chen H, Gao X, Cheng H, An Y, Chu C, Liu G. Ruthenium-Based Metal-Organic Nanoradiosensitizers Enhance Radiotherapy by Combining ROS Generation and CO Gas Release. Angew Chem Int Ed Engl. 2022 Dec 12;61(50):e202211674. doi: 10.1002/anie.202211674. Zhang Z, Fang C, Zhang Y, Su S, Li B, Liu G, Hu Z, Tian J. NIR-II nano fluorescence image guided hepatic carcinoma resection on cirrhotic patient. Photodiagnosis Photodyn Ther. 2022 Dec;40:103098. doi: 10.1016/j.pdpdt.2022.103098. Li Z, Cheng H, Mao J, Liu G. Conversion therapy of intermediate and advanced hepatocellular carcinoma using superstable homogeneous iodinated formulation technology. Sci China Life Sci. 2022 Oct;65(10):2114-2117. doi: 10.1007/s11427-022-2142-3. Men X, Geng X, Zhang Z, Chen H, Du M, Chen Z, Liu G, Wu C, Yuan Z. Biomimetic semiconducting polymer dots for highly specific NIR-II fluorescence imaging of glioma. Mater Today Bio. 2022 Aug 7;16:100383. doi:10.1016/j.mtbio.2022.100383. Ren E, Chen H, Qin Z, Guan S, Jiang L, Pang X, He Y, Zhang Y, Gao X, Chu C, Zheng L, Liu G. Harnessing Bifunctional Ferritin with Kartogenin Loading for Mesenchymal Stem Cell Capture and Enhancing Chondrogenesis in Cartilage Regeneration. Adv Healthc Mater. 2022 Apr;11(8):e2101715. doi: 10.1002/adhm.202101715. Zhang Y, Cheng H, Chen H, Xu P, Ren E, Jiang Y, Li D, Gao X, Zheng Y, He P, Lin H, Chen B, Lin G, Chen A, Chu C, Mao J, Liu G. A pure nanoICG-based homogeneous lipiodol formulation: toward precise surgical navigation of primary liver cancer after long-term transcatheter arterial embolization. Eur J Nucl Med Mol Imaging. 2022 Jul;49(8):2605-2617. doi: 10.1007/s00259-021-05654-z. Liu J, Fu S, Xie J, Zhang J, Pan J, Chu C, Liu G, Ju S. Application of Self-Assembly Nanoparticles Based on DVDMS for Fenton-Like Ion Delivery and Enhanced Sonodynamic Therapy. Biosensors (Basel). 2022 Apr 18;12(4):255. doi: 10.3390/bios12040255. Qiu Q, Huang Y, Zhang B, Huang D, Chen X, Fan Z, Lin J, Yang W, Wang K, Qu N, Li J, Li Z, Huang J, Li S, Zhang J, Liu G, Rui G, Chen X, Zhao Q. Noninvasive Dual-Modality Photoacoustic-Ultrasonic Imaging to Detect Mammalian Embryo Abnormalities after Prenatal Exposure to Methylmercury Chloride (MMC): A Mouse Study. Environ Health Perspect. 2022 Feb;130(2):27002. doi: 10.1289/EHP8907. Ma X, Yang S, Zhang T, Wang S, Yang Q, Xiao Y, Shi X, Xue P, Kang Y, Liu G, Sun ZJ, Xu Z. Bioresponsive immune-booster-based prodrug nanogel for cancer immunotherapy. Acta Pharm Sin B. 2022 Jan;12(1):451-466. doi:10.1016/j.apsb.2021.05.016. Li D, Pan J, Xu S, Fu S, Chu C, Liu G. Activatable Second Near-Infrared Fluorescent Probes: A New Accurate Diagnosis Strategy for Diseases. Biosensors (Basel). 2021,11:436. Li L, Lin H, Li D, Zeng Y, Liu G. Ultrasound activated nanosensitizers for sonodynamic therapy and theranostics. Biomed Mater. 2021,6(2):022008. Li D, Yang Y, Li D, Pan J, Chu C, Liu G. Organic Sonosensitizers for Sonodynamic Therapy: From Small Molecules and Nanoparticles toward Clinical Development. Small. 2021;17(42):e2101976. He P, Guan S, Ren E, Chen H, Chen H, Peng Y, Luo B, Xiong Y, Li B, Li J, Mao J, Liu G. Precision Interventional Brachytherapy: A Promising Strategy Toward Treatment of Malignant Tumors. Front Oncol. 2021;11:753286. Xie L, Zhang X, Chu C, Dong Y, Zhang T, Li X, Liu G, Cai W, Han S. Preparation, toxicity reduction and radiation therapy application of gold nanorods. J Nanobiotechnology. 2021;19(1):454. Jin R, Zhu W, Lin G, Liu G, Ai H. MRI-Visible Nanovehicle for Efficient siRNA Delivery. Methods Mol Biol. 2021;2282:195-208. Wang J, Mei L, Tao W, Liu G. Editorial: Emerging Advances in Bio-Nano ngineered Approaches Toward Intelligent Nanomedicine. Front Bioeng Biotechnol. 2021;9:703227. Shi X, Zhang Y, Tian Y, Xu S, Ren E, Bai S, Chen X, Chu C, Xu Z, Liu G. Multi-Responsive Bottlebrush-Like Unimolecules Self-Assembled Nano-Riceball for Synergistic Sono-Chemotherapy. Small Methods. 2021 Mar;5(3):e2000416. doi: 10.1002/smtd.202000416. Fan X, Ke L, Cheng H, Chen H, Li Z, Ye E, Loh XJ, Wu YL, Liu G, Li Z. Enhanced drug retention by anthracene crosslinked nanocomposites for bimodal imaging-guided phototherapy. Nanoscale. 2021 Sep 17;13(35):14713-14722. doi: 10.1039/d1nr04171a. Bai S, Lu Z, Jiang Y, Shi X, Xu D, Shi Y, Lin G, Liu C, Zhang Y, Liu G. Nanotransferrin-Based Programmable Catalysis Mediates Three-Pronged Induction of Oxidative Stress to Enhance Cancer Immunotherapy. ACS Nano. 2022 Jan 25;16(1):997-1012. doi: 10.1021/acsnano.1c08619. Ren E, Liu C, Lv P, Wang J, Liu G. Genetically Engineered Cellular Membrane Vesicles as Tailorable Shells for Therapeutics. Adv Sci (Weinh). 2021 Nov;8(21):e2100460. doi: 10.1002/advs.202100460. Peng X, Lin G, Zeng Y, Lei Z, Liu G. Mesoporous Silica Nanoparticle-Based Imaging Agents for Hepatocellular Carcinoma Detection. Front Bioeng Biotechnol. 2021 Nov 16;9:749381. doi: 10.3389/fbioe.2021.749381. Xu S, Shi X, Chu C, Liu G. A TME-activated in situ nanogenerator for magnetic resonance/fluorescence/photoacoustic imaging. Methods Enzymol. 2021;657:145-156. doi: 10.1016/bs.mie.2021.06.029. Chen C, Sun M, Liu X, Wu W, Su L, Li Y, Liu G, Yan X. General and mild modification of food-derived extracellular vesicles for enhanced cell targeting. Nanoscale. 2021 Feb 11;13(5):3061-3069. doi: 10.1039/d0nr06309f. Lin G, Zhang Y, Liu G. Biosynthetic magnetic nanocages: towards effective and safe magneto-catalytic cancer therapy. Sci Bull (Beijing). 2021 Apr 15;66(7):640-642. doi: 10.1016/j.scib.2020.12.010. Lv P, Chen X, Fu S, Ren E, Liu C, Liu X, Jiang L, Zeng Y, Wang X, Liu G. Surface engineering of oncolytic adenovirus for a combination of immune checkpoint blockade and virotherapy. Biomater Sci. 2021 Nov 9;9(22):7392-7401. doi: 10.1039/d1bm00928a. Lei Z, Zhang Y, Liu G. eMIONs: novel genetically engineered nanocages for magnetic hyperthermia cancer therapy. Mol Cell Oncol. 2021 Jan 11;8(1):1863739. doi: 10.1080/23723556.2020.1863739. Zhou C, Zhang L, Sun T, Zhang Y, Liu Y, Gong M, Xu Z, Du M, Liu Y, Liu G, Zhang D. Activatable NIR-II Plasmonic Nanotheranostics for Efficient Photoacoustic Imaging and Photothermal Cancer Therapy. Adv Mater. 2021 Jan;33(3):e2006532. doi: 10.1002/adma.202006532. Lin H, Zhou Y, Wang J, Wang H, Yao T, Chen H, Zheng H, Zhang Y, Ren E, Jiang L, Chu C, Chen X, Mao J, Wang F, Liu G. Repurposing ICG enables MR/PA imaging signal amplification and iron depletion for iron-overload disorders. Sci Adv. 2021 Dec 17;7(51):eabl5862. doi: 10.1126/sciadv.abl5862. Sun T, Liu Y, Zhou C, Zhang L, Kang X, Xiao S, Du M, Xu Z, Liu Y, Liu G, Gong M, Zhang D. Fluorine-mediated synthesis of anisotropic iron oxide nanostructures for efficient T2-weighted magnetic resonance imaging. Nanoscale. 2021 Apr 30;13(16):7638-7647. doi: 10.1039/d1nr00338k. Shi Y, Lin G, Zheng H, Mu D, Chen H, Lu Z, He P, Zhang Y, Liu C, Lin Z, Liu G. Biomimetic nanoparticles blocking autophagy for enhanced chemotherapy and metastasis inhibition via reversing focal adhesion disassembly. J Nanobiotechnology. 2021 Dec 24;19(1):447. doi: 10.1186/s12951-021-01189-5. Huang D, Wang G, Mao J, Liu C, Fan Z, Zhang Y, Zhang B, Zhao Y, Dai C, He Y, Ma H, Liu G, Chen X, Zhao Q. Intravital Whole-Process Monitoring Thermo-Chemotherapy Via 2D Silicon Nanoplatform: A Macro Guidance and Long-Term Microscopic Precise Imaging Strategy. Adv Sci (Weinh). 2021 Aug;8(16):e2101242. doi: 10.1002/advs.202101242.

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