Liang, Steven H. - Harvard Medical School

个人简介

Academic Appointment 2013- Assistant Professor of Radiology, Member of Gordon Center for Molecular Imaging, Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital and Harvard Medical School Education Tianjin University (1999-2003, B.Sc.); University of British Columbia (2004-2010, Ph.D., Advisor: Prof. Marco Ciufolini); Harvard University (2010-2012, NSERC Fellow, Advisor: Prof. E.J. Corey)

研究领域

PET Biomarker Development 1. PET tracer development and imaging studies in the endocannabinoid system, CB1, CB2, fatty acid amide hydrolase (FAAH), monoacylglycerol lipase (MAGL or MGL), diacylglycerol lipase (DAGL), ABHD6 and ABHD12 2. PET tracer development and imaging studies in neurodegenerative disorders, Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), multiple sclerosis (MS), Huntington's disease (HD) and dementia with Lewy bodies (DLB) Precision Radiochemistry 1. Novel radiochemical method on aryl-[18F]fluorine bond formation and [18F]-multifluoromethylation 2. 11CO2 fixation technology 3. Bioconjugation reaction with biological molecules, including aptamer, peptide and protein

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Josephson, L., Stratman, N., Liu, Y., Qian, F., Liang, S. H., Vasdev, N. and Patel, S. "The Binding of BF-227-Like Benzoxazoles to Human α-Synuclein and Amyloid β Peptide Fibrils" Mol. Imaging, 2018, ASAP, DOI: 10.1177/1536012118796297. Fu, H., Chen, Z., Josephson, L., Li, Z. and Liang, S. H. "Positron Emission Tomography (PET) Ligand Development for Ionotropic Glutamate Receptors: Challenges and Opportunities for Radiotracer Targeting N-methyl-D-aspartate (NMDA), alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) and Kainate Receptors" J. Med. Chem., 2018, ASAP, DOI: 10.1021/acs.jmedchem.8b00714. Chen, Z., Mori, W., Zhang, X., Yamasaki, T., Dunn, P. J., Zhang, G. W., Fu, H., Shao, T., Zhang, Y., Hatori, A., Ma, L., Fujinaga, M., Xie, L., Deng, X., Li, H., Yu, Q., Rong, J., Josephson, L., Ma, J., Shao, Y., Tomita, S., Zhang, M. R., and Liang, S. H. "Synthesis and preclinical evaluation of 11C-labeled 1,3-dihydro-2H-benzo[d]imidazol-2-ones for imaging studies towards γ8-dependent transmembrane AMPA receptor regulatory protein" Eur. J. Med. Chem., 2018, ASAP. DOI: https://doi.org/10.1016/j.ejmech.2018.08.019 Cheng, S., Jacobson, O., Zhu, G., Chen, Z., Liang, S. H., Tian, R., Yang, Z., Niu, G., Zhu, X and Chen, X. "PET imaging of EGFR expression using an 18F-labeled RNA aptamer." Eur. J. Nucl. Med. Mol. Imaging, 2018, ASAP, DOI: 10.1007/s00259-018-4105-1. Zheng, C., Wang, Y., Xu, Y., Chen, Z., Chen, G., and Liang, S. H. "Ru-Photoredox-Catalyzed Decarboxylative Oxygenation of Aliphatic Carboxylic Acids through N-(acyloxy)phthalimide" Org. Lett., 2018, ASAP. DOI: 10.1021/acs.orglett.8b01885. Deng, X., Rong, J., Wang, L., Vasdev, N., Zhang, L., Josephson, L., and Liang, S. H. "Chemistry for Positron Emission Tomography: Recent Advances in 11C-, 18F-, 13N- and 15O-labeling Reactions" Angew. Chem. Int. Ed., 2018, ASAP. DOI: 10.1002/anie.201805501. Rong, J. and Liang, S. H. "Aliphatic [18F]Fluorination Chemistry for Positron Emission Tomography", in Synthetic Organofluorine Chemistry, Springer, New York, 2018, accepted. Yamasaki, T., Mori, W., Zhang, Y., Hatori, A., Fujinaga, M., Wakizaka, H., Kurihara, Y., Wang, L., Nengaki, N., Ohya, T., Liang, S. H. and Zhang, M-R. "First demonstration of in vivo mapping for regional brain monoacylglycerol lipase using PET with [11C]SAR127303" NeuroImage, 2018, accepted. DOI: 10.1016/j.neuroimage.2018.05.015. Collier, T. L.; Dahl, K.; Stephenson, N. A.; Holland, J. P.; Riley, A.; Liang, S. H. and Vasdev, N. "Recent applications of a single quadrupole mass spectrometer in 11C, 18F and radiometal chemistry" J Fluorine Chem, 2018, accepted. Cheng, R.; Mori, W.; Ma, L.; Alhouayek, M.; Hatori, A.; Zhang, Y.; Ogasawara, D.; Yuan, G.; Chen, Z.; Zhang, X.; Shi, H.; Yamasaki, T.; Xie, L.; Kumata, K.; Fujinaga, M.; Nagai, Y.; Minamimoto, T.; Svensson, M.; Wang, L.; Du, Y.; Ondrechen, M.; Vasdev, N.; Cravatt, B. F.; Fowler, C.; Zhang, M-R. and Liang, S. H. "In vitro and in vivo evaluation of 11C-labeled azetidine-carboxylates for imaging monoacylglycerol lipase by PET imaging studies" J Med Chem, 2018, 61, 2278-2291. DOI: 10.1021/acs.jmedchem.7b01400. [link] [full-text] Krishnan, H. S.; Bernard-Gauthier, V.; Placzek, M. S.; Dahl, K.; Narayanaswami, V.; Livni, E.; Chen, Z.; Yang, J.; Collier, T. L.; Ran, C.; Hooker, J. M.; Liang, S. H. and Vasdev, N. “Metal protein-attenuating compound for PET neuroimaging: synthesis and preclinical evaluation of [11C]PBT2” Mol Pharm, 2018, 15, 695-702. DOI: 10.1021/acs.molpharmaceut.7b00936 [link] Collier, T. L.; Liang, S. H.; Mann, J. J.; Vasdev, N. and Kumar, J. S. D. "Microfluidic radiosynthesis of [18F]FEMPT, a high affinity PET radiotracer for imaging serotonin receptors" Beilstein J. Org. Chem., 2017, 13, 2922-2927. DOI: 10.3762/bjoc.13.285 [full-text] Bernard-Gauthier, V.; Legage, M.; Waengler, B.; Bailey, J. A.; Liang, S. H.; Perrin, D.; Vasdev, N. and Schirrmacher, R. "Recent advances in fluorine-18 radiochemistry: Focus on B-18F, Si-18F, Al-18F and C-18F radiofluorination via spirocyclic iodonium ylides" J Nucl. Med., 2017, asap. DOI: 10.2967/jnumed.117.197095 Zhang, X.; Kumata, K.; Yamasaki, T.; Cheng, R.; Hatori, A.; Ma, L.; Zhang, Y.; Wang, L.; Kang, H. J.; Sheffler, D. J.; Cosford, N. D. P.; Zhang, M-R & Liang, S. H. "Synthesis and Preliminary Studies of a Novel Negative Allosteric Modulator, 7-((2,5-Dioxopyrrolidin-1-yl)methyl)-4-(2-fluoro-4-[11C]methoxyphenyl) quinoline-2-carboxamide for Imaging of Metabotropic Glutamate Receptor 2" ACS Chem. NeuroSci. 2017, 8, 1937-1948. [link] [full-text] Collier, T. L.; Maresca K. P.; Normandin, M. D.; Richardson, P.; McCarthy, T. J.; Liang, S. H.; Waterhouse, R. N. & Vasdev, N. "Brain Penetration of the ROS1/ALK Inhibitor Lorlatinib Confirmed by PET" Mol. Imaging, 2017, DOI: 10.1177/1536012117736669. [link] Bernard-Gauthier, V.; Collier, T. L.; Liang, S. H. & Vasdev, N. "Discovery of PET Radiopharmaceuticals at the Academia-Industry Interface" Drug Discov. Today Technol., 2017, accepted. [link] Ran, C.; Albrecht, D. S.; Bredella, M. A.; Yang, J.; Yang, J.; Liang, S. H.; Cypress, A. M.; Loggia, M. L.; Atassi, N. & Moore, A. "PET imaging of human brown adipose tissue with TSPO tracer [11C]PBR28" Mol. Imaging Biol., 2017, accepted. [link] Yuan, G.; Jankins, T. C.; Patrick, C. G.; Philbrook, P.; Sears, O.; Hatfield, S.; Sitkovsky, M.; Vasdev, N.; Liang, S. H.; Ondrechen, M. J.; Pollastri, M. P. & Jones, G. B. "Fluorinated adenosine A2A receptor antagonists inspired by Preladenant as potential cancer immunotherapeutics" Int. J. Med. Chem., 2017, article ID 4852537. [link] Krishnan, H.; Ma, L.; Vasdev, N. & Liang S. H. "18F-Labeling of Sensitive Biomolecules for Positron Emission Tomography" Chem. Eur. J. 2017, 23, 15553 - 15577. [link] [full-text] Yang, J.; Yang, J.; Wang, L.; Moore, A.; Liang, S. H. & Ran, C. "Synthesis-Free PET Imaging of Brown Adipose Tissue and TSPO via Combination of Disulfiram and 64CuCl2" Sci. Rep. 2017, 7, 8298. [link]