Nixon, Gemma - University of Liverpool - Department of Chemistry

个人简介

Dr Gemma Nixon's research career began with the completion of a PhD for Dr Ian O’Neil (Department of Chemistry, University of Liverpool) in 2006. She then completed a one year Post Doctoral position with Prof Paul O’Neill (Department of Chemistry, University of Liverpool) working on endoperoxide antimalarials (funded by AntiMal) before joining the company Peakdale Molecular in Januray 2008. In March 2009 she began a Post Doctoral position at Liverpool School of Tropical Medicine (LSTM) with Prof Steve Ward working on a Seeding Drug Discovery Malaria Project (funded by Wellcome Trust) before moving to a Scientific Team Leader role with Prof Giancarlo Biagini on an MRC DFPS funded TB Drug Development Program. In 2013 Gemma took up the role of Chemistry Team Leader on the AWOL II: Macrofilaricidial Drug Discovery Project at LSTM (funded by the Bill & Melinda Gates Foundation (BMGF)) whilst pursuing her own independent research interests. In April 2015 Gemma was appointed to a joint lectureship between the Department of Chemistry and the Institute of Translational Medicine and in May 2016 was awarded an MRC New Investigator Research Grant to investigate the 'Rational Design, Synthesis and Biological Evaluation of Benzimidazoles; Towards a Novel Therapy Selectively Targeting C. neoformans β-tubulin' Research interests include several areas of medicinal chemistry drug discovery and target identification. With a strong emphasis on development of novel therapies used in the treatment of tuberculosis, malaria, Cryptococcus neoformans and filariasis. Teaching interests include organic chemistry and medicinal chemistry from core principles through to their application in current drug discovery programmes Anti-infective Drug Discovery; From Anti-malarial Endoperoxides to Anti-fungal Benzimidazoles (Invitation to Speak, University of Sussex 2016) Associate Member (Higher Education Academy 2013) An Introduction to Malaria (Invitation to Speak, Liverpool John Moores 2011) An Introduction to Tuberculosis (Invitation to Speak, Liverpool Life Sciences UTC 2013) Current Concepts in Drug Discovery and Development – The Role of Chemistry - Online Lecture (Invitation to Speak, Chulabhorn International College of Medicine, Thailand 2014) From the Natural Herb Qinghaosu (Artemisinin) to Orally Active Synthetic Endoperoxide Antimalarials (Invitation to Speak, 41st European Symposium on Bio-Organic Chemistry 2007) Generation of quinolone antimalarials targeting the Plasmodium falciparum mitochondrial respiratory chain for the treatment and prophylaxis of malaria. (Invitation to Speak, RSTMH: Discovery and Delivery of New Paradigms for Global Health 2012)

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Antimalarial Chemotherapy: Natural Product Inspired Development of Preclinical and Clinical Candidates with Diverse Mechanisms of Action Optimisation of the synthesis of second generation 1,2,4,5 tetraoxane antimalarials Tripodal Tris-N-oxides: Synthesis and Hydrogen Bonding Capabilities 2-Pyridylquinolone antimalarials with improved antimalarial activity and physicochemical properties Carbamoyl Triazoles, Known Serine Protease Inhibitors, Are a Potent New Class of Antimalarials Inhibitors of the Plasmodium mitochondrial respiratory chain Antimalarial pharmacology and therapeutics of atovaquone Targeting the mitochondrial electron transport chain of Plasmodium falciparum: new strategies towards the development of improved antimalarials for the elimination era Antimalarial pharmacology and therapeutics of atovaquone Generation of quinolone antimalarials targeting the Plasmodium falciparum mitochondrial respiratory chain for the treatment and prophylaxis of malaria Identification of Novel Antimalarial Chemotypes via Chemoinformatic Compound Selection Methods for a High-Throughput Screening Program against the Novel Malarial Target, PfNDH2: Increasing Hit Rate via Virtual Screening Methods Identification, Design and Biological Evaluation of Bisaryl Quinolones Targeting Plasmodium falciparum Type II NADH:Quinone Oxidoreductase (PfNDH2) A novel drug for uncomplicated malaria: Targeted high throughput screening (HTS) against the type II NADH:ubiquinone oxidoreductase (PfNDH2) of Plasmodium falciparum Development of a novel drug for uncomplicated malaria targeting the mitochondrial NADH:quinone oxidoreductase Endoperoxide Carbonyl Falcipain 2/3 Inhibitor Hybrids: Toward Combination Chemotherapy of Malaria through a Single Chemical Entity Identification of a 1,2,4,5-Tetraoxane Antimalarial Drug-Development Candidate (RKA 182) with Superior Properties to the Semisynthetic Artemisinins Synthesis, in vitro and in vivo antimalarial assessment of sulfide, sulfone and vinyl amide-substituted 1,2,4-trioxanes prepared via thiol-olefin co-oxygenation (TOCO) of allylic alcohols Synthesis, Antimalarial Activity, and Preclinical Pharmacology of a Novel Series of 4 '-Fluoro and 4 '-Chloro Analogues of Amodiaquine. Identification of a Suitable "Back-Up" Compound for N-tert-Butyl Isoquine An efficient route into synthetically challenging bridged achiral 1,2,4,5-tetraoxanes with antimalarial activity Piperidine dispiro-1,2,4-trioxane analogues Two-step synthesis of achiral dispiro-1,2,4,5-tetraoxanes with outstanding antimalarial activity, low toxicity, and high-stability profiles Evidence for a Common Non-Heme Chelatable-Iron-Dependent Activation Mechanism for Semisynthetic and Synthetic Endoperoxide Antimalarial Drugs The diastereoselective synthesis of functionalised spirocyclic lactams and lactones using a Cope elimination/intramolecular nitrone cycloaddition strategy The synthesis of functionalised chiral bicyclic lactam and lactone N-oxides using a tandem Cope elimination/reverse Cope elimination protocol The diastereoselective synthesis of functionalised isoxazolidines using a Cope elimination/intramolecular nitrone cycloaddition strategy