McDonald, Thomas - University of Liverpool

个人简介

Tom graduated with a BSc and MSc from School of Materials in Manchester in 2005, before obtaining a PhD in 2008. His research focussed on the design and synthesis of enzyme responsive hydrogels for drug delivery, under the supervision of Prof. Rein Ulijn and Prof. Brian Saunders at the University of Manchester. He then worked from Unilever as a research scientist investigating the delivery of home and personal-care actives, before joining the University of Liverpool as a postdoctoral research associate working in Prof. Steve Rannard's group, where he developed drug nanoparticles for the treatment of HIV/AIDS. Tom went on to work in the group of Prof. Andy Cooper in 2012, undertaking research investigating the high throughput synthesis and characterisation of microporous polymers. In November 2013, he was appointed to a Lectureship in Nanomedicine, his current research interests include the synthesis of nanomaterials for drug delivery and the design of responsive hydrogels for biomedical applications.

研究领域

Tom's research is focussed on synthesis of nanomaterials for drug delivery and the design of responsive hydrogels for biomedical applications.

近期论文

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Accelerated oral nanomedicine discovery from miniaturized screening to clinical production exemplified by paediatric HIV nanotherapies Hierarchically porous carbon foams from pickering high internal phase emulsions Stable, polymer-directed and SPION-nucleated magnetic amphiphilic block copolymer nanoprecipitates with readily reversible assembly in magnetic fields A low molecular weight hydrogel with unusual gel aging Augmented Inhibition of CYP3A4 in Human Primary Hepatocytes by Ritonavir Solid Drug Nanoparticles Hydrogels formed from Fmoc amino acids Lipase-Catalyzed Dissipative Self-Assembly of a Thixotropic Peptide Bolaamphiphile Hydrogel for Human Umbilical Cord Stem-Cell Proliferation Photodimerisation of a coumarin-dipeptide gelator Polymerization of low molecular weight hydrogelators to form electrochromic polymers Probing gelation ability for a library of dipeptide gelators Spatially resolved multicomponent gels The Application of Nanotechnology to Drug Delivery in Medicine Using intermolecular interactions to crosslink PIM-1 and modify its gas sorption properties Using the hydrolysis of anhydrides to control gel properties and homogeneity in pH-triggered gelation Air-stable photoconductive films formed from perylene bisimide gelators Antiretroviral Solid Drug Nanoparticles with Enhanced Oral Bioavailability: Production, Characterisation and In Vitro-In Vivo Correlation Electrochemically-triggered spatially and temporally resolved multi-component gels Hyperbranched polydendrons: a new controlled macromolecular architecture with self-assembly in water and organic solvents Shining a Light on s-Triazine-Based Polymers The application of nanotechnology to drug delivery in Medicine The effect of self-sorting and co-assembly on the mechanical properties of low molecular weight hydrogels The in vivo effects of solid drug nanoparticle and conventional efavirenz on anxiogenesis in rodents Compositions of Lopinavir and Ritonavir Dynamic Nuclear Polarization NMR Spectroscopy Allows High-Throughput Characterization of Microporous Organic Polymers Enhanced Pharmacological Properties of Efavirenz Formulated as Solid Drug Nanoparticles