Phelan, Marie - University of Liverpool - Department of Biochemistry

个人简介

NMR Technologist & Shared Research Facility Manager NMR Centre for Structural Biology HLS Technology Directorate

研究领域

NMR, Metabolomics, Protein structure, nucleic acid structure, molecular structure, protein-protein interactions, binding affinity, ITC, drug-protein interaction, homology modelling, protein dynamics, micelle-protein interaction, membrane protein, chemical atomic structure.

近期论文

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A novel MC4R deletion coexisting with FTO and MC1R gene variants, causes severe early onset obesity Genetic screening of non-classic CAH females with hyperandrogenemia identifies a novel CYP11B1 gene mutation. In silico analysis of a novel MKRN3 missense mutation in familial central precocious puberty Microform Holoprosencephaly with Bilateral Congenital Elbow Dislocation; Increasing the Phenotypic Spectrum of Steinfeld Syndrome NMR Metabolomics: A Comparison of the Suitability of Various Commonly used National Health Service Blood Collection Tubes H-1, N-15 and C-13 assignment of the amyloidogenic protein medin using fast-pulsing NMR techniques Oxidative Stress Alters the Morphology and Toxicity of Aortic Medial Amyloid Comparative study of the molecular variation between 'central' and 'peripheral' MUPs and significance for behavioural signalling NMR elucidation of the role of Mg2+ in the structure and stability of the conserved RNA motifs of the EMCV IRES element The Structure, Stability and Pheromone Binding of the Male Mouse Protein Sex Pheromone Darcin The major urinary protein system in the rat The structure, stability and pheromone binding of the male mouse protein sex pheromone darcin A report of 2 new cases of MODY2 and review of the literature: Implications in the search for type 2 Diabetes drugs. Conformational Characterization of Synapse-Associated Protein 97 by Nuclear Magnetic Resonance and Small-Angle X-ray Scattering Shows Compact and Elongated Forms Evidence for Metabolic Cleavage of a PEGylated Protein in Vivo Using Multiple Analytical Methodologies. NMR Structure of Hsp12, a Protein Induced by and Required for Dietary Restriction-Induced Lifespan Extension in Yeast Structure and Assembly of a Trans-Periplasmic Channel for Type IV Pili in Neisseria meningitidis The structure and selectivity of the SR protein SRSF2 RRM domain with RNA Building up a picture of C7 on the basis of high-resolution structure of its component modules Characterisation of the dynamics and interactions of detergent micelles and the Neisseria meningitidis outer membrane protein OpcA H-1, N-15 and C-13 resonance assignment of darcin, a mouse major urinary protein The 1H, 13C and 15N backbone and side-chain assignment of the RRM domain of SC35, a regulator of pre-mRNA splicing 1H, 15N and 13C resonance assignment of the pair of Factor-I like modules of the complement protein C7 Solution Structure of Factor I-like Modules from Complement C7 Reveals a Pair of Follistatin Domains in Compact Pseudosymmetric Arrangement The 3D structure of factor I-like modules from C7 provides structural and functional insights into assembly of the MAC.