Mason, Dave - University of Liverpool - Department of Biochemistry

个人简介

I completed my PhD in Toronto under the supervision of Sergio Grinstein at the Hospital for Sick Children. My main area of study was the modulation of Actin and Lipids during phagocytosis and during bacterial Host-Pathogen interactions. During this time, I acquired a lot of hands-on experience with light microscopy which has driven my research interests ever since. I returned to the UK to take up a Marie Curie International Incoming Fellowship (IIF) at the University of Birmingham studying bacterial adhesion using fast 4D acquisition and post-acquisition tracking. Since joining the University of Liverpool on an MRC Next Generation Optical Imaging Initiative, my Research has focused on developing Stochastic Optical Fluctuation Imaging (SOFI) on epifluorescent hardware. My other roles involve Research Data Management and supporting users of the Centre for Cell Imaging (CCI) with post-acquisition image analysis, which is also the focus of my blog.

近期论文

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Transcriptional responses to hyperplastic MRL signalling in Drosophila Differential sub-nuclear distribution of hypoxia-inducible factors (HIF)-1 and-2 alpha impacts on their stability and mobility. Elastase levels and activity are increased in dystrophic muscle and impair myoblast cell survival, proliferation and differentiation Selectivity in glycosaminoglycan binding dictates the distribution and diffusion of fibroblast growth factors in the pericellular matrix. The Spherical Nucleic Acids mRNA Detection Paradox The Spherical Nucleic Acids mRNA Detection Paradox Measures of kidney function by minimally invasive techniques correlate with histological glomerular damage in SCID mice with adriamycin-induced nephropathy. In situ measurement of the electrical potential across the lysosomal membrane using FRET Localized diacylglycerol-dependent stimulation of Ras and Rap1 during phagocytosis Modulation of integrin-linked kinase nucleo-cytoplasmic shuttling by ILKAP and CRM1 Alteration of epithelial structure and function associated with PtdIns(4,5)P2 degradation by a bacterial phosphatase. Quantitative analysis of membrane remodeling at the phagocytic cup Signaling-dependent immobilization of acylated proteins in the inner monolayer of the plasma membrane. Accumulation of diacylglycerol in the Chlamydia inclusion vacuole: possible role in the inhibition of host cell apoptosis.