Fisher, Michael - University of Liverpool - Department of Biochemistry

研究领域

Molecular mechanisms controlling the expression and functional activity of enzymes and other regulatory proteins. These include both short-term processes (e.g. reversible phosphorylation) and longer-term alterations in expression (e.g. transcriptional control). The role of hormones and novel nucleotide effectors (e.g. Ap4A) in stimulating changes in intermediary metabolism. Covalent modification of proteins with lipid groups (e.g. fatty acylation and isoprenylation).

近期论文

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tructural diversity of the cAMP-dependent protein kinase regulatory subunit in Caenorhabditis elegans. Characterisation of the N′1 isoform of the cyclic AMP-dependent protein kinase (PK-A) catalytic subunit in the nematode, Caenorhabditis elegans. Efficient identification of proteins from ovaries and hepatopancreas of the unsequenced edible crab, Cancer pagurus, by mass spectrometry and homology-based, cross-species searching. Studies on the C. elegans protein kinase A (PK-A) regulatory subunit gene (kin-2). In 34th FEBS Congress - Life's Molecular Interactions. Studies on the C. elegans Protein kinase A (PK-A) Regulatory Subunit Gene (kin-2). Studies on the C. elegans protein kinase A (PK-A) catalytic and regulatory subunit genes. siRNA-mediated knockdown of a splice variant of the PK-A catalytic subunit gene causes adult-onset paralysis in C. elegans. Expression of multiple isoforms of the cAMP-dependent protein kinase (PK-A) catalytic subunit in the nematode, Caenorhabditis elegans. Molecular characterisation of cAMP-dependent protein kinase (PK-A) catalytic subunit isoforms in the male tick, Amblyomma hebraeum. Developing models of protein signalling agents.