Edwards, Steven - University of Liverpool - Department of Biochemistry

研究领域

Regulation of function of blood phagocytes during infections; cancer cell killing; inflammatory disease, especially rheumatoid arthritis; cytokine regulated processes; role of gene expression in rescue of neutrophils from apoptosis; molecular processes that up- or down-regulate phagocyte function and identification of new targets for the design of novel pro or anti-inflammatory agents. Apoptosis in cancer cells. Transcriptomics using next generation sequencing.

近期论文

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Thieblemont, N., Wright, H. L., Edwards, S. W., & Witko-Sarsat, V. (2016). Human neutrophils in auto-immunity. SEMINARS IN IMMUNOLOGY, 28(2), 159-173. doi:10.1016/j.smim.2016.03.004 Wright, H. L., Makki, F. A., Moots, R. J., & Edwards, S. W. (2016). Low-density granulocytes: functionally distinct, immature neutrophils in rheumatoid arthritis with altered properties and defective TNF signalling.. Journal of leukocyte biology. Wright, H. L., Cox, T., Moots, R. J., & Edwards, S. W. (2016). Neutrophil biomarkers predict response to therapy with tumor necrosis factor inhibitors in rheumatoid arthritis.. Journal of leukocyte biology. Phoomvuthisarn, P., Wright, H. L., Clark, R. E., Mutirangura, A., & Edwards, S. W. (2016). The Cdk2 inhibitor, Purvalanol A, induces apoptosis is myeloid cells via p38-MAPK dependent turnover of Mcl-1. In EUROPEAN JOURNAL OF CLINICAL INVESTIGATION Vol. 46 (pp. 81). Retrieved from http://gateway.webofknowledge.com/ Tamarozzi, F., Turner, J. D., Pionnier, N., Midgley, A., Guimaraes, A. F., Johnston, K. L., . . . Taylor, M. J. (2016). Wolbachia endosymbionts induce neutrophil extracellular trap formation in human onchocerciasis. SCIENTIFIC REPORTS, 6. doi:10.1038/srep35559 Osborne, S., Farrell, J., Dearman, R. J., MacIver, K., Naisbitt, D. J., Moots, R. J., . . . Goebel, A. (2015). Cutaneous immunopathology of long-standing complex regional pain syndrome. EUROPEAN JOURNAL OF PAIN, 19(10), 1516-1526. doi:10.1002/ejp.685 Chiewchengchol, D., Wright, H. L., Thomas, H. B., Lam, C. W., Roberts, K. J., Hirankarn, N., . . . Edwards, S. W. (2016). Differential changes in gene expression in human neutrophils following TNF-α stimulation: Up-regulation of anti-apoptotic proteins and down-regulation of proteins involved in death receptor signaling.. Immunity, inflammation and disease, 4(1), 35-44. doi:10.1002/iid3.90 Veraldi, N., Hughes, A. J., Rudd, T. R., Thomas, H. B., Edwards, S. W., Hadfield, L., . . . Yates, E. A. (2015). Heparin derivatives for the targeting of multiple activities in the inflammatory response. Carbohydrate Polymers, 117, 400-407. doi:10.1016/j.carbpol.2014.09.079 Wright, H. L., Thomas, H. B., Moots, R. J., & Edwards, S. W. (2015). Interferon gene expression signature in rheumatoid arthritis neutrophils correlates with a good response to TNFi therapy. RHEUMATOLOGY, 54(1), 188-193. doi:10.1093/rheumatology/keu299 Flanagan, P. K., Chiewchengchol, D., Wright, H. L., Edwards, S. W., Alswied, A., Satsangi, J., . . . Campbell, B. J. (2015). Killing of Escherichia coli by Crohn's Disease Monocyte-derived Macrophages and Its Enhancement by Hydroxychloroquine and Vitamin D. INFLAMMATORY BOWEL DISEASES, 21(7), 1499-1510. doi:10.1097/MIB.0000000000000387 Chiewchengchol, D., Murphy, R., Edwards, S. W., & Beresford, M. W. (2015). Mucocutaneous manifestations in juvenile-onset systemic lupus erythematosus: a review of literature. PEDIATRIC RHEUMATOLOGY, 13. doi:10.1186/1546-0096-13-1 Wright, H. L., Mewar, D., Bucknall, R. C., Edwards, S. W., & Moots, R. J. (2015). Synovial fluid IL-6 concentrations associated with positive response to tocilizumab in an RA patient with failed response to anti-TNF and rituximab. RHEUMATOLOGY, 54(4), 743-744. doi:10.1093/rheumatology/keu488 Chiewchengchol, D., Midgley, A., Sodsai, P., Deekajorndech, T., Hirankarn, N., Beresford, M. W., & Edwards, S. W. (2015). The protective effect of GM-CSF on serum-induced neutrophil apoptosis in juvenile systemic lupus erythematosus patients. CLINICAL RHEUMATOLOGY, 34(1), 85-91. doi:10.1007/s10067-014-2800-2 Thomas, H. B., Moots, R. J., Edwards, S. W., & Wright, H. L. (2015). Whose Gene Is It Anyway? The Effect of Preparation Purity on Neutrophil Transcriptome Studies. PLOS ONE, 10(9). doi:10.1371/journal.pone.0138982