Singh, Ishwar - University of Lincoln

个人简介

Ishwar Singh is a Senior Lecturer in Biological Chemistry at the School of Pharmacy, University of Lincoln. Prior to Lincoln, he had held many prestigious fellowships such as the Alexander von Humboldt fellowship, Germany; and Senior Research Fellowship, DANIDA, Denmark and CSIR, India. He is an organic chemist. He has developed bioconjugations for DNA, RNA and polymer modifications in water. He is currently leading research in Biologics delivery, Peptides, Sequence selective DNA cross linking, Nanoparticles modifications for drug delivery and diagnostic applications and broad spectrum antibiotics, novel antimicrobials based on rational design against clinically important resistant Gram negative such as K. pneumoniae 700603, A. Baumannii 19606, P. aeruginosa 28753 and chemistry tools for spatial surface modifications for diagnostic and preventive applications. Total synthesis of Teixobactin analogues Department Responsibilities Member of the international committee, Chemistry tutor Personal Tutor Subject Specialism Chemical Biology, Organic Chemitsry, Bioconjugations, Biologics Delivery, Nucleic Acids and Peptides, antimicrobials Qualifications PhD — 2004 MPhil — 1999 MSc — 1997 Awards Immuno-NanoDecoder — Horizon 2020, EU, 2014 The Royal Society Research Grant Award — Royal Society, 2013 Alexander von Humboldt Fellowship — AvH Foundation Germany, 2004 Senior Research Fellowship — CSIR India, 2001 Professional Affiliations Royal Society of Chemistry — Member

研究领域

Marie Curie Fellowships — Please contact us if you are motivated and have good CV. in 2014 Biologic Delivery — Fully funded PhD position available. Please see http://www.findaphd.com/search/ProjectDetai in 2014 Broad Spectrum Antimicrobials — RIF in 2013 Bioconjugations — 2013 Defining a chemical lexicon for tumour-specific delivery of biologics — Royal Society in 2013 Development of Sequence selective DNA-crosslinking Agents

近期论文

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Parmar, Anish and Prior, Stephen H. and Iyer, Abhishek and Vincent, Charlotte S. and Van Lysebetten, Dorien and Breukink, Eefjan and Madder, Annemieke and Taylor, Edward J. and Singh, Ishwar (2017) Defining the molecular structure of teixobactin analogues and understanding their role in antibacterial activities. Chemical Communications. ISSN: 1359-7345 Parmar, Anish and Iyer, Abhishek and Vincent, Charlotte and Van Lysebetten, Dorien and Prior, Stephen H. and Madder, Annemieke and Taylor, Edward J. and Singh, Ishwar (2016) Efficient total syntheses and biological activities of two teixobactin analogues. Chemical Communications, 52 (36). pp. 6060-6063. ISSN: 1359-7345 Henry, Sarah L. and Withers, Jamie M. and Singh, Ishwar and Cooper, Jonathan M. and Clark, Alasdair W. and Burley, Glenn A. and Cogdell, Richard J. (2015) DNA-directed spatial assembly of photosynthetic light-harvesting proteins. Organic & Biomolecular Chemistry, 14 (4). pp. 1359-1362. ISSN: 1477-0520 Singh, Ishwar and Heaney, Frances and Batchelor, Caroline and Vyle, Joseph S. (2015) Metal free click chemistry on nucleosides and oligonucleotides. Collection of Czechoslovak Chemical Communications, 10. pp. 451-451. ISSN: 0010-0765 Freeman, Colin and Cheallaigh, Aisling Ni and Singh, Ishwar and Heaney, Frances (2015) Isoxazole linked oligonucleotide conjugates by on resin and previously clicked nitrile oxide alkyne cycloadditions. Collection of Czechoslovak Chemical Communications, 12. pp. 333-333. ISSN: 0010-0765 Vllasaliu, Driton and Singh, Ishwar (2014) Particle characterisation in drug delivery. European Pharmaceutical Review, 2014 (4). ISSN: 1360-8606 Fallows, Andrew J. and Singh, Ishwar and Dondi, Ruggero and Cullis, Paul M. and Burley, Glenn A. (2014) Highly efficient synthesis of DNA-binding polyamides using a convergent fragment-based approach. Organic Letters, 16 (17). pp. 4654-4657. ISSN: 1523-7060 Singh, Ishwar (2013) General discussion on self-assembly of biopolymers. Faraday Discussions, 166. pp. 117. ISSN: 1359-6640 Singh, Ishwar (2013) General discussion on self-assembly of biopolymers. Faraday Discussions, 166. pp. 223-242. ISSN: 1359-6640 Singh, Ishwar (2013) General discussion on self-assembly of biopolymers. Faraday Discussions, 166. pp. 331-348. ISSN: 1359-6640 Singh, Ishwar (2013) General discussion on self-assembly of biopolymers. Faraday Discussions, 166. pp. 431-448. ISSN: 1359-6640 Singh, Ishwar and Wendeln, Christian and Clark, Alasdair W. and Cooper, Jonathan M. and Ravoo, Bart Jan and Burley, Glenn A. (2013) Sequence-selective detection of double-stranded DNA sequences using pyrrole-imidazole polyamide microarrays. Journal of the American Chemical Society , 135 (9). pp. 3449-3457. ISSN: 0002-7863 Singh, Ishwar and Freeman, Colin and Madder, Annemieke and Vyle, Joseph S. and Heaney, Frances (2012) Fast RNA conjugations on solid phase by strain-promoted cycloadditions. Organic and Biomolecular Chemistry, 10 (33). pp. 6633-6639. ISSN: 1477-0520 Wendeln, Christian and Singh, Ishwar and Rinnen, Stefan and Schulz, Christian and Arlinghaus, Heinrich F. and Burley, Glenn A. and Ravoo, Bart Jan (2012) Orthogonal, metal-free surface modification by strain-promoted azide-alkyne and nitrile oxide-alkene/alkyne cycloadditions. Chemical Science, 3 (8). pp. 2479-2484. ISSN: 2041-6520 Krpetic, Zeljka and Singh, Ishwar and Su, Wu and Guerrini, Luca and Faulds, Karen and Burley, Glenn A. and Graham, Duncan (2012) Directed assembly of DNA-functionalized gold nanoparticles using pyrrole-imidazole polyamides. Journal of the American Chemical Society, 134 (20). pp. 8356-8359. ISSN: 0002-7863 Davis, Carol and Gordon, Natasha and Murphy, Sinead and Singh, Ishwar and Kavanagh, Kevin and Carberry, Stephen and Doyle, Sean (2011) Single-pot derivatisation strategy for enhanced gliotoxin detection by HPLC and MALDI-ToF mass spectrometry. Analytical and Bioanalytical Chemistry, 401 (8). pp. 2519-2529. ISSN: 1618-2642 Singh, Ishwar and Freeman, Colin and Heaney, Frances (2011) Efficient synthesis of DNA conjugates by strain-promoted azide-cyclooctyne cycloaddition in the solid phase. European Journal of Organic Chemistry (33). pp. 6739-6746. ISSN: 1434-193X Davis, Carol and Carberry, Stephen and Schrettl, Markus and Singh, Ishwar and Stephens, John C. and Barry, Sarah M. and Kavanagh, Kevin and Challis, Gregory L. and Brougham, Dermot and Doyle, Sean (2011) The role of glutathione S-Transferase GliG in gliotoxin biosynthesis in Aspergillus fumigatus. Chemistry and Biology, 18 (4). pp. 542-552. ISSN: 1074-5521 Singh, Ishwar and Heaney, Frances (2011) Solid phase strain promoted "click'' modification of DNA via [3+2]-nitrile oxide-cyclooctyne cycloadditions. Chemical Communications, 47 (9). pp. 2706-2708. ISSN: 1359-7345 Singh, Ishwar and Zarafshani, Zoya and Heaney, Frances and Lutz, Jean-Francois (2011) Orthogonal modification of polymer chain-ends via sequential nitrile oxide-alkyne and azide-alkyne Huisgen cycloadditions. Polymer Chemistry, 2 (2). pp. 372-375. ISSN: 1759-9954 Bethge, Lucas and Singh, Ishwar and Seitz, Oliver (2010) Designed thiazole orange nucleotides for the synthesis of single labelled oligonucleotides that fluoresce upon matched hybridization. Organic and Biomolecular Chemistry, 8 (10). pp. 2439-2448. ISSN: 1477-0520 Algay, Virginie and Singh, Ishwar and Heaney, Frances (2010) Nucleoside and nucleotide analogues by catalyst free Huisgen nitrile oxide-alkyne 1,3-dipolar cycloaddition. Organic and Biomolecular Chemistry, 8 (2). pp. 391-397. ISSN: 1477-0520 Singh, Ishwar and Heaney, Frances (2010) Metal free, "click and click-click'' conjugation of ribonucleosides and 2'-OMe oligoribonucleotides on the solid phase. Organic and Biomolecular Chemistry, 8 (2). pp. 451-456. ISSN: 1477-0520 Singh, Ishwar and Zarafshani, Zoya and Lutz, Jean-Francois and Heaney, Frances (2009) Metal-Free "Click'' chemistry: efficient polymer modification via 1,3-dipolar cycloaddition of nitrile oxides and alkynes. Macromolecules, 42 (15). pp. 5411-5413. ISSN: 0024-9297 Singh, Ishwar and Vyle, Joseph S. and Heaney, Frances (2009) Fast, copper-free click chemistry: a convenient solid-phase approach to oligonucleotide conjugation. Chemical Communications, 45 (22). pp. 3276-3278. ISSN: 1359-7345