Ngomba, Richard - University of Lincoln

个人简介

Richard Ngomba is a Senior Lecturer in School of Pharmacy in College of Science. He graduated from the School of Pharmacy at the University of Perugia, Italy, in Chemistry and Pharmaceutical Technologies in 1996. He then obtained a PharmD equivalent qualification as a Pharmacist in the same university . Richard subsequently obtained a PhD from the University “G. D’Annunzio”, Chieti, Italy, in 2001. Before joining the University of Lincoln, he was working at IRCCS Neuromed Neurological Institute, Italy, specialising in specific areas of neuroscience and pharmacology. He has been Honorary Research Associate at UCL’s Institute of Ophthalmology - Visual Neuroscience, and visiting researcher and lecturer at the University of Lille 1, France. He has conducted extensive investigations into the science behind neurological conditions such as epilepsy and stroke, and has led studies into a condition called ‘absence epilepsy’ in children, which is less well-known than other types of epilepsy in which the sufferer experiences convulsions. Because the condition is more difficult to spot, it often goes undetected for long. In the last decade, Richard has been working on rodent models of absence epilepsy in collaboration with colleagues from Donders Institute, University of Nijmegen, Netherlands. He has been a visiting instructor at Stanford University Medical Center, where he further developed his understanding of the cortico-thalamo-cortical network (the principal anatomical structure for the development of absence epilepsy) by employing in vitro electrophysiology models. Richard is specialized in studying neuroscience at the cellular level, and at Lincoln he will continue his intricate work to scrutinize the causes and triggers of specific neurological conditions. His research examines the properties of cells with mutated genes and how the mutations are involved in epilepsy, stroke and psychiatric disorders. Despite his focus on basic and translational research, Richard maintains his commitment to patient care by practicing at out-patient pharmacies around Lincolnshire on a weekly basis. Subject Specialism Pharmacology and Therapeutics; Neuroscience; Pharmacy Practice Qualifications PhD — University “G. D’Annunzio”, Chieti, Italy, 2001 PharmD — School of Pharmacy University of Perugia, Italy, 1996 Professional Affiliations Royal Pharmaceutical Society — MRPharmS Society for Neuroscience, USA — Regular member General Pharmaceutical Council — Registered Pharmacist External Activities and Consultancy CNS Neuroscience & Therapeutics (Wiley-Blackwell) - Editorial Board member Springer-Verlag, NY, USA, for the Series - Contracted Chapter Editor Current Neuropharmacology - Reviewer Journal of Neural Transmission - Reviewer Outpatient Pharmacy - @ ULH- NHS Trust Lincolnshire

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Tchekalarova, Jana and Moyanova, Slavianka and Fusco, Antonio De and Ngomba, Richard Teke (2015) The role of the melatoninergic system in epilepsy and comorbid psychiatric disorders. Brain Research Bulletin, 119 (A). pp. 80-92. ISSN: 0361-9230 D'Amore, Valerio and von Randow, Constanze and Nicoletti, Ferdinando and Ngomba, Richard and van Luijtelaar, Gilles (2015) Anti-absence activity of mGlu1 and mGlu5 receptor enhancers and their interaction with a GABA reuptake inhibitor: effect of local infusions in the somatosensory cortex and thalamus. Epilepsia, 56 (7). pp. 1141-51. ISSN: 0013-9580 Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new?. Current Opinion in Pharmacology, 20. pp. 89-94. ISSN: 14714892 D'Amore, V. and Santolini, I. and Celli, R. and Lionetto, L. and De Fusco, A. and Simmaco, M. and van Rijn, C. M. and Vieira, E. and Stauffer, S.R. and Conn, P. J. and Bosco, P. and Nicoletti, F. and van Luijtelaar, G. and Ngomba, R. T. (2014) Head-to head comparison of mGlu1 and mGlu5 receptor activation in chronic treatment of absence epilepsy in WAG/Rij rats. Neuropharmacology, 85. pp. 91-103. ISSN: 0028-3908 Moyanova, S. G. and Mitreva, R. G. and Kortenska, L. V. and Nicoletti, F. and Ngomba, R.T. (2013) Age-dependence of sensorimotor and cerebral electroencephalographic asymmetry in rats subjected to unilateral cerebrovascular stroke. Experimental and Translational Stroke Medicine, 5 (1). ISSN: 2040-7378 Citraro, R. and Russo, E. and Ngomba, R.T. and Nicoletti, F. and Scicchitano, F. and Whalley, B.J. and Calignano, A. and De Sarro, G. (2013) CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations. Epilepsy Research, 106 (1-2). pp. 74-82. ISSN: 0920-1211 D'Amore, V. and Santolini, I. and van Rijn, C.M. and Biagioni, F. and Molinaro, G. and Prete, A. and Conn, P.J. and Lindsley, C.W. and Zhou, Y. and Vinson, P.N. and Rodriguez, A.L. and Jones, C.K and Stauffer, S.R. and Nicoletti, F. and van Luijtelaar, G. and Ngomba, R.T. (2013) Potentiation of mGlu5 receptors with the novel enhancer, VU0360172, reduces spontaneous absence seizures in WAG/Rij rats.. Neuropharmacology, 66. pp. 330-338. ISSN: 0028-3908 Marrocco, J. and Mairesse, J. and Ngomba, R.T. and Silletti, V. and Van Camp, G. and Bouwalerh, H. and Summa, M. and Pittaluga, A. and Nicoletti, F. and Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN: 0270-6474 Fazio, F. and Lionetto, L. and Molinaro, G. and Bertrand, H.O. and Acher, F. and Ngomba, R.T. and Notartomaso, S. and Curini, M. and Rosati, O. and Scarselli, P. and Di Marco, R.a and Battaglia, G. and Bruno, V. and Simmaco, M. and Pin, J.P. and Nicoletti, F. and Goudet, C. (2012) Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type 4 metabotropic glutamate receptors. Molecular Pharmacology, 81 (5). pp. 643-656. ISSN: 0026-895X Ngomba, Richard Teke and Santolini, I. and Salt, T. E. and Ferraguti, F. and Battaglia, G. and Nicoletti, F. and Van Luijtelaar, G. (2011) Metabotropic glutamate receptors in the thalamocortical network: strategic targets for the treatment of absence epilepsy. Epilepsia, 52 (7). pp. 1211-1222. ISSN: 0013-9580 Ngomba, R. T. and Santolini, I. and Biagioni, F. and Molinaro, G. and Simonyi, A. and Van Rijn, C. M. and D'Amore, V. and Mastroiacovo, F. and Olivieri, G. and Gradini, R. and Ferraguti, F. and Battaglia, G. and Bruno, V. and Puliti, A. and Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN: 0028-3908 Moyanova, S. G. and Mastroiacovo, F. and Kortenska, L. V. and Mitreva, R. G. and Fardone, E. and Santolini, I. and Sobrado, M. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Ngomba, R. T. (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 31 (4). pp. 1107-1118. ISSN: 0271-678X Van Rijn, C. M. and Gaetani, S. and Santolini, I. and Badura, A. and Gabova, A. and Fu, J. and Watanabe, M. and Cuomo, V. and Van Luijtelaar, G. and Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN: 0013-9580 Epifano, F. and Molinaro, G. and Genovese, S. and Ngomba, Richard T. and Nicoletti, F. and Curini, M. (2008) Neuroprotective effect of prenyloxycoumarins from edible vegetables. Neuroscience Letters, 443 (2). pp. 57-60. ISSN: 0304-3940 Bikbaev, A. and Neyman, S. and Ngomba, Richard and Conn, J. and Nicoletti, F. and Manahan-Vaughan, D. (2008) MGluR5 mediates the interaction between late-LTP, network activity, and learning. PLoS ONE, 3 (5). ISSN: 1932-6203 Ngomba, Richard T. and Ferraguti, F. and Badura, A. and Citraro, R. and Santolini, I. and Battaglia, G. and Bruno, V. and De Sarro, G. and Simonyi, A. and van Luijtelaar, G. and Nicoletti, F. (2008) Positive allosteric modulation of metabotropic glutamate 4 (mGlu4) receptors enhances spontaneous and evoked absence seizures. Neuropharmacology, 54 (2). pp. 344-354. ISSN: 0028-3908 Nicoletti, F. and Battaglia, G. and Storto, M. and Ngomba, Richard T. and Iacovelli, L. and Arcella, A. and Gradini, R. and Sale, P. and Rampello, L. and De Vita, T. and Di Marco, R. and Melchiorri, D. and Bruno, V. (2007) Metabotropic glutamate receptors: Beyond the regulation of synaptic transmission. Psychoneuroendocrinology, 32 (Supp 1). pp. S40-S45. ISSN: 0306-4530 Moyanova, S.G. and Kortenska, L.V. and Mitreva, R.G. and Pashova, V.D. and Ngomba, R.T. and Nicoletti, F. (2007) Multimodal assessment of neuroprotection applied to the use of MK-801 in the endothelin-1 model of transient focal brain ischemia. Brain Research, 1153 (1). pp. 58-67. ISSN: 0006-8993 Ngomba, R. T. and Biagioni, F. and Casciato, S. and Willems-Van Bree, E. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Van Luijtelaar, E. L. J. M. (2005) The preferential mGlu2/3 receptor antagonist, LY341495, reduces the frequency of spike-wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 49 (SUPPL.). pp. 89-103. ISSN: 0028-3908 Arcella, A. and Carpinelli, G. and Battaglia, G. and D'Onofrio, M. and Santoro, F. and Ngomba, R. T. and Bruno, V. and Casolini, P. and Giangaspero, F. and Nicoletti, F. (2005) Pharmacological blockade of group II metabotropic glutamate receptors reduces the growth of glioma cells in vivo. Neuro-Oncology, 7 (3). pp. 236-245. ISSN: 1522-8517 Simonyi, Agnes and Ngomba, Richard T. and Storto, Marianna and Catania, Maria V. and Miller, Laura A. and Youngs, Brian and DiGorgi-Gerevini, Valeria and Nicoletti, Ferdinando and Sun, Grace Y. (2005) Expression of groups I and II metabotropic glutamate receptors in the rat brain during aging. Brain Research, 1043 (1-2). pp. 95-106. ISSN: 0006-8993 Matrisciano, F. and Scaccianoce, S. and Del Bianco, P. and Panaccione, I. and Canudas, A. M. and Battaglia, G. and Riozzi, B. and Ngomba, R. T. and Molinaro, G. and Tatarelli, R. and Melchiorri, D. and Nicoletti, F. (2005) Metabotropic glutamate receptors and neuroadaptation to antidepressants: imipramine-induced down-regulation of β-adrenergic receptors in mice treated with metabotropic glutamate 2/3 receptor ligands. Journal of Neurochemistry, 93 (5). pp. 1345-1352. ISSN: 0022-3042 Granata, Filippo and Potenza, Rossella Luisa and Fiori, Anna and Strom, Roberto and Caronti, Brunella and Molinari, Paola and Donsante, Sonia and Citro, Gennaro and Iacovelli, Luisa and De Blasi, Antonio and Ngomba, Richard T. and Palladini, Guido and Passarelli, Francesca (2003) Expression of OP4 (ORL1, NOP1) receptors in vascular endothelium. European Journal of Pharmacology, 482 (1-3). pp. 17-23. ISSN: 0014-2999 Cinque, C. and Zuena, A .R. and Casolini, P. and Ngomba, Richard T. and Melchiorri, D. and Maccari, S. and Nicoletti, F. and Di Giorgi Gerevini, V. and Catalani, A. (2003) Reduced activity of hippocampal group-I metabotropic glutamate receptors in learning-prone rats. Neuroscience, 122 (1). pp. 277-284. ISSN: 0306-4522 Storto, Marianna and Ngomba, Richard T. and Battaglia, Giuseppe and Freitas, Isabel and Griffini, Patrizia and Richelmi, Plinio and Nicoletti, Ferdinando and Vairetti, Mariapia (2003) Selective blockade of mGlu5 metabotropic glutamate receptors is protective against acetaminophen hepatotoxicity in mice. Journal of Hepatology, 38 (2). pp. 179-187. ISSN: 0168-8278