Gruber, Tobias - University of Lincoln

个人简介

Tobias obtained a chemistry degree in 2004 and a PhD in organic and supramolecular chemistry in 2008 from the University of Freiberg/Saxony (PhD adviser: Edwin Weber). After one year at the Institute of Pharmaceutical Sciences in the group of Manfred Jung (Freiburg/Breisgau), where Tobias worked on the development of histone deacetylase inhibitors, he moved to the University of Oxford for a postdoctoral stay in the group of Christopher Schofield to perform research in the field of antibiotics. In 2011, Tobias started his independent research career in Braunschweig and moved later back to Freiberg. Since November 2015, Tobias is a Senior Lecturer in the College of Science in Lincoln. His research interests include artificial receptors for biologically active compounds, medicinal chemistry and crystal engineering. The outcome of this research is of interest to a number other science branches, e.g. Biology and Medicine. Recent research deals with selective receptors for methylammonium ions. These occur as structural motifs in a variety of biological active compounds, e.g. as post-translational methylation of lysine residues in respective proteins or small molecules like acetylcholine, ephedrine or methamphetamine. They have high medicinal relevance, though some are used illicitly. A specific complexation of such compounds is an envisaged basis for sensor active materials, which will open new fields in the field of diagnostics and therapy. A second branch of Tobias’ research provides the basis for a novel synthesis pathway of bicyclic gamma-lactams from the somewhat larger caprolactams. Further elaboration of these synthetic sequences will contribute to the preparation of new antibiotics and lactamase inhibitors to be used against resistant bacteria strains. In the last years Tobias established a network of national and international collaborators. Main scientific partners outside of Lincoln are: Prof Christopher Schofield (Oxford), Prof Dirk Labudde (Mittweida), Dr Ivanhoe Leung (Auckland), Dr Petra Bombicz (Budapest), Dr Alexander Wolf (Munich). Department Responsibilities Personal tutor Subject Specialism Drug delivery & Formulation, Crystallography & Polymorphism, Supramolecular & Organic Chemistry Qualifications Associate Fellow of the Higher Education Academy — The Higher Education Academy, 2016 Dr. rer. nat. ( = PhD) — University of Freiberg/Saxony (Germany), 2008 Dipl.-Chem. ( = MSc in Chemistry) — University of Freiberg/Saxony (Germany), 2004 Professional Affiliations Royal Society of Chemistry — Regular member ‘Liebig-Vereinigung fuer Organische Chemie’ — Regular member German Chemical Society (GDCh) — Regular member External Activities and Consultancy Journal of Molecular Structure - Reviewer

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Augustin, Andre U. and Katzsch, Felix and Prior, Stephen H. and Gruber, Tobias (2017) Supramolecular layers and versatile packing modes: the solid state behavior of ortho, ortho-linked bisphenols. Journal of Molecular Structure. ISSN: 0022-2860 Hanauer, Thomas and Hopkinson, Richard J and Patel, Kamel and Li, Yu and Correddu, Danilo and Kawamura, Akane and Sarojini, Vijay and Leung, Ivanhoe K. H. and Gruber, Tobias (2017) Selective recognition of the di/trimethylammonium motif by an artificial carboxycalixarene receptor. Organic & Biomolecular Chemistry. ISSN: 1477-0520 Katzsch, Felix and Gruber, Tobias and Weber, Edwin (2016) Crystal structures of functional building blocks derived from di(benzo[b]thien-2-yl)methane. Acta Crystallographica C: Structural Chemistry, 72 (9). pp. 679-684. ISSN: 2053-2296 Katzsch, Felix and Gruber, Tobias and Weber, Edwin (2016) Structural studies on inclusion compounds and solvent sorption behavior of gradually elongated wheel-and-axle-type diol hosts featuring lateral benzo[b]thiophene units. Journal of Molecular Structure, 1114. pp. 48-64. ISSN: 0022-2860 Katzsch, Felix and Gruber, Tobias and Weber, Edwin (2016) Trimethyl 3,3',3''-(benzene-1,3,5-triyl)tripropynoate. IUCrData, 1 (4). pp. x160629. ISSN: 2414-3146 Weck, Christian and Katzsch, Felix and Gruber, Tobias (2015) Synthesis, conformational parameters and packing considerations of methyl bispyridyl ketones. Journal of Molecular Structure, 1098. pp. 261-266. ISSN: 0022-2860 Katzsch, Felix and Gruber, Tobias and Weber, Edwin (2015) Crystalline inclusion of wheel-and-axle diol hosts featuring benzo[b]thiophene units as a lateral construction element. Crystal Growth & Design, 15 (10). pp. 5047-5061. ISSN: 1528-7483 Bürger, Marcel and Katzsch, Felix and Brendler, Erica and Gruber, Tobias (2015) Synthesis of macrocyclic receptors with intrinsic fluorescence featuring quinizarin moieties. The Journal of Organic Chemistry, 80 (10). pp. 4882-4892. ISSN: 0022-3263 Gruber, Tobias and Thompson, Amber L. and Odell, Barbara and Bombicz, Petra and Schofield, Christopher J. (2014) Conformational studies on substituted ε-caprolactams by X-ray crystallography and NMR spectroscopy. New Journal of Chemistry, 38 (12). pp. 5905-5917. ISSN: 1144-0546 Münch, Alexander S. and Katzsch, Felix and Gruber, Tobias and Mertens, Florian O.R.L. (2014) Spectroscopic, thermal and single crystal structure investigations of 2-bromotrimesic acid and its trimethyl ester analogue. Journal of Molecular Structure, 1074. pp. 542-548. ISSN: 0022-2860 Gruber, Tobias and Eißmann, Frank and Gruner, Margit and Heinz, Luisa G. and Seichter, Wilhelm and Weber, Edwin (2014) Simple dinitro substituted calix[4]arene forming a honeycomb-like architecture with hydrophobic channels. CrystEngComm, 16 (18). pp. 3730-3736. ISSN: 1466-8033 Bombicz, Petra and Gruber, Tobias and Fischer, Conrad and Weber, Edwin and Kálmán, Alajos (2014) Fine tuning of crystal architecture by intermolecular interactions: synthon engineering. CrystEngComm, 16 (18). pp. 3646. ISSN: 1466-8033 Gruber, Tobias and Nestler, Robert and Seichter, Wilhelm and Bombicz, Petra (2014) Crystal structures and isometricity comparison of methylated bisphenol F derivatives. Journal of Molecular Structure, 1056-7. pp. 319-325. ISSN: 0022-2860 Gruber, Tobias and Schofield, Christopher J. and Thompson, Amber L. (2012) 3-Methoxy-3-oxopropanaminium chloride. Acta Crystallographica Section E: Structure Reports Online, 68 (3). pp. o595. ISSN: 0365-110X Gruber, Tobias and Schofield, Christopher J. and Thompson, Amber L. (2012) Methyl 6-amino-6-oxohexanoate. Acta Crystallographica Section E: Structure Reports Online, 68 (3). pp. o593-o594. ISSN: 0365-110X Gruber, Tobias and Eissmann, Frank and Weber, Edwin and Schüürmann, Gerrit (2011) 1-Methyl-4-(4-nitrobenzoyl)pyridinium perchlorate. Acta Crystallographica Section E: Structure Reports Online, 67 (9). pp. o2542-o2543. ISSN: 0365-110X Fischer, Conrad and Gruber, Tobias and Seichter, Wilhelm and Weber, Edwin (2011) Bridge-substituted calix[4]arenes: syntheses, conformations and application. Organic & Biomolecular Chemistry, 9 (11). pp. 4347-4352. ISSN: 1477-0520 Fischer, Conrad and Gruber, Tobias and Eissmann, Diana and Seichter, Wilhelm and Weber, Edwin (2011) Unusual behavior of a calix[4]arene featuring the coexistence of basic cone and 1,2-alternate conformations in a solvated crystal. Crystal Growth & Design, 11 (5). pp. 1989-1994. ISSN: 1528-7483 Gruber, Tobias and Fischer, Conrad and Seichter, Wilhelm and Bombicz, Petra and Weber, Edwin (2011) Upper rim site lipophilic calix[4]arenes as receptors for natural terpenes and functionally related solvent molecules: combined crystal structure and QMB sensor study. CrystEngComm, 13 (5). pp. 1422-1431. ISSN: 1466-8033 Gruber, Tobias and Helas, Stefanie F. and Seichter, Wilhelm and Weber, Edwin (2010) X-ray crystal structures of two solvent complexes involving positionally isomeric 9,10-anthraquinonecarboxylic acids and DMSO. Structural Chemistry, 21 (5). pp. 1079-1083. ISSN: 1040-0400 Gruber, Tobias and Eissmann, Frank and Seichter, Wilhelm and Weber, Edwin (2010) 25-Allyloxy-5,11,17,23-tetra-tert-butyl-26,27,28-trihydroxycalix[4]arene chloroform disolvate. Acta Crystallographica Section C: Crystal Structure Communications, 66 (7). pp. o334-o336. ISSN: 0365-110X Gruner, Margit and Fischer, Conrad and Gruber, Tobias and Weber, Edwin (2010) Influence of laterally attached alkyl groups on the conformational behaviour of a basic calix[4]arene: combined NMR, molecular mechanics and X-ray study. Supramolecular Chemistry, 22 (4). pp. 256-266. ISSN: 1061-0278 Gruber, Tobias and Seichter, Wilhelm and Weber, Edwin (2010) 1-(Hydroxymethyl)pyrene. Acta Crystallographica Section E: Structure Reports Online, 66 (2). pp. o443. ISSN: 0365-110X Gruber, Tobias and Gruner, Margit and Fischer, Conrad and Seichter, Wilhelm and Bombicz, Petra and Weber, Edwin (2010) Conformational behaviour and first crystal structures of a calix[4]arene featuring a laterally positioned carboxylic acid function in unsolvated and solvent-complexed forms. New Journal of Chemistry, 34 (2). pp. 250. ISSN: 1144-0546 Gruber, Tobias and Fischer, Conrad and Felsmann, Marika and Seichter, Wilhelm and Weber, Edwin (2009) Calix[4]arenes featuring a direct lower rim attachment of dansyl groups. Synthesis, fluorescence properties and first report on crystal structures. Organic & Biomolecular Chemistry, 7 (23). pp. 4904-4917. ISSN: 1477-0520