个人简介
Prof Nicholas Blagden holds the Chair in Pharmaceutics at the School of Pharmacy, University of Lincoln from December 2012. He has a joint honours degree in chemistry and physics, (1984-1987), and a DPhil in chemical physics (1992) under the supervision of Professor Kenneth Seddon. Prior taking up his current post Blagden was a Reader in Solid State Pharmaceutics at the Univeristy of Bradford (2001 to 2012), and has also worked as a Crystallisation Specialist for Avecia (2000-2001). He has undertaken postdoctoral work in crystal growth, crystal engineering and polymorphism at UMIST with Professor Roger Davey (1995-2000) and bio-mineralization with Professor Brigid Heywood (1993-1995). Blagden has published two book chapters, over sixty papers, four reviews, holds two patents, and has given 42 invited lectures to both academic and industrial conferences. He has chaired sessions at the 2003 congress of the International Union of Crystallography on “insitu monitoring of crystallization”, 2006 BCA spring meeting on “crystal engineering”, and 2008 BCA session on “x-ray diffraction studies of crystallisation.” Blagden has specialized in the relationship between molecular self-association observed in solution with the molecular assembly of the solid phase, and the impact this has on the physico-chemical or biophysical behaviour of materials. His research has contributed a number of notable first in the area of polymorph selection, pre-nucleation, co-crystals, molecular solid nano particles, and. the manipulation of morphology using nucleation templates, Recent work has focused on the design and the crystal growth of co-crystals to improve a drugs bio availability. His early work on polymorphism has been recognized by the award of the British Association of Crystal Growth Young Scientist medal in 1997. He has served on the British Association of Crystal Growth Committee and was involved in Nano-factory within the Yorkshire region.
Department Responsibilities
Member Senior Management Team Pharmacy
Director of Research Pharmacy
Co-Chair Life Science-Pharmacy-Chemistry Research Committee
REF submission working group Pharmacy Research Co-ordinator
Subject Specialism
Physical Pharmaceutics, Crystallisation and Crystal Engineering
Qualifications
HEA Fellow — HEA, 2007
DPhil — Sussex, 1992
BSc (hons) — Staffordshire, 1988
MRSC — Royal Society Chemistry, -198
近期论文
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Munshi, Tasnim and Redha, Batul and Feeder, Neil and Meenan, Paul and Blagden, Nicholas (2016) Impact of mixed solvent on co-crystal solubility, ternary phase diagram and crystallisation scale up. Crystal Growth & Design. ISSN: 1528-7483
Kulkarni, Chaitrali and Wood, Clive and Kelly, Adrian L. and Gough, Tim and Blagden, Nicholas and Paradkar, Anant (2015) Stoichiometric control of co-crystal formation by solvent free continuous co-crystallization (SFCC). Crystal Growth & Design, 15 (12). pp. 5648-5651. ISSN: 1528-7483
Blagden, Nicholas and Coles, S. J. and Berry, D. J. (2014) Pharmaceutical co-crystals: are we there yet?. CrystEngComm, 16 (26). pp. 5753-5761. ISSN: 1466-8033
Amani, Amir and Ali, Hany and Blagden, Nicholas and York, Peter (2014) Evaluation of a nanodispersion formulation prepared through microfluidic reactors for pulmonary delivery of budesonide using nebulizers. Iranian Journal of Pharmaceutical Research, 13 (3). pp. 785-796. ISSN: 1735-0328
Soon, C. F. and Omar, W. I. W. and Berends, R. F. and Nayan, N. and Basri, H. and Tee, K. S. and Youseffi, M. and Blagden, Nicholas and Denyer, M. C. T. (2014) Biophysical characteristics of cells cultured on cholesteryl ester liquid crystals. Micron, 56. pp. 73-79. ISSN: 0968-4328
Soon, Chin Phong and Khaghani, Seyed Ali and Youseffi, Mansour and Nayan, Nafarizal and Saim, Hashim and Britland, Stephen and Blagden, Nicholas and Denyer, Morgan Clive Thomas (2013) Interfacial study of cell adhesion to liquid crystals using widefield surface plasmon resonance microscopy. Colloids and Surfaces B: Biointerfaces, 110. pp. 156-162. ISSN: 0927-7765
Seaton, Colin C. and Blagden, Nicholas and Munshi, Tasnim and Scowen, Ian J. (2013) Creation of ternary multicomponent crystals by exploitation of charge-transfer interactions. Chemistry - A European Journal, 19 (32). pp. 10663-10671. ISSN: 0947-6539
Soon, C. F. and Youseffi, M. and Berends, R. F. and Blagden, Nicholas and Denyer, M. C. T. (2013) Development of a novel liquid crystal based cell traction force transducer system. Biosensors and Bioelectronics, 39 (1). pp. 14-20. ISSN: 0956-5663
Jones, A. O. F. and Blagden, Nicholas and McIntyre, G. J. and Parkin, A. and Seaton, C. C. and Thomas, L. H. and Wilson, C. C. (2013) Tuning proton disorder in 3,5-dinitrobenzoic acid dimers: the effect of local environment. Crystal Growth and Design, 13 (2). pp. 497-509. ISSN: 1528-7483
Ali, H. S. M. and York, P. and Blagden, Nicholas and Khoubnasabjafari, M. and Acree Jr., W. E. and Jouyban, A. (2012) Solubility of salbutamol and salbutamol sulphate in ethanol + water mixtures at 25°c. Journal of Molecular Liquids, 173. pp. 62-65. ISSN: 0167-7322
Shariare, Mohammad H. and Blagden, Nicholas and de Matas, Marcel and Leusen, Frank J. J. and York, Peter (2012) Influence of solvent on the morphology and subsequent comminution of ibuprofen crystals by air jet milling. Journal of Pharmaceutical Sciences, 101 (3). pp. 1108-1119. ISSN: 0022-3549
Soon, C. F. and Youseffi, M. and Gough, T. and Blagden, Nicholas and Denyer, M. C. T. (2011) Rheological characterization and in-situ investigation of the time-dependent cholesteric based lyotropic liquid crystals. Materials Science and Engineering C, 31 (7). pp. 1389-1397. ISSN: 0928-4931
Ibrahim, Asim Y. and Forbes, Robert T. and Blagden, Nicholas (2011) Spontaneous crystal growth of Co-crystals: the contribution of particle size reduction and convection mixing of the co-formers. CrystEngComm, 13 (4). pp. 1141-1152. ISSN: 1466-8033
Ali, Hany S. M. and York, Peter and Ali, Ahmed M. A. and Blagden, Nicholas (2011) Hydrocortisone nanosuspensions for ophthalmic delivery: a comparative study between microfluidic nanoprecipitation and wet milling. Journal of Controlled Release, 149 (2). pp. 175-181. ISSN: 0168-3659
Soon, C. F. and Youseffi, M. and Blagden, Nicholas and Denyer, M. (2011) Investigation of cell adhesion, contraction and physical restructuring on shear sensitive liquid crystals. Lecture Notes in Electrical Engineering, 90 LNE. pp. 623-635. ISSN: 1876-1100
Thomas, L. H. and Blagden, Nicholas and Gutmann, M. J. and Kallay, A. A. and Parkin, A. and Seaton, C. C. and Wilson, C. C. (2010) Tuning proton behavior in a ternary molecular complex. Crystal Growth and Design, 10 (6). pp. 2770-2774. ISSN: 1528-7483
Ali, Hany S. M. and York, Peter and Blagden, Nicholas and Soltanpour, Shahla and Acree Jr., William E. and Jouyban, Abolghasem (2010) Solubility of budesonide, hydrocortisone, and prednisolone in ethanol + water mixtures at 298.2 K. Journal of Chemical and Engineering Data, 55 (1). pp. 578-582. ISSN: 0021-9568
Ali, Hany S. M. and Blagden, Nicholas and York, Peter and Amani, Amir and Brook, Toni (2009) Artificial neural networks modelling the prednisolone nanoprecipitation in microfluidic reactors. European Journal of Pharmaceutical Sciences, 37 (3-4). pp. 514-522. ISSN: 0928-0987
Ali, Hany S. M. and York, Peter and Blagden, Nicholas (2009) Preparation of hydrocortisone nanosuspension through a bottom-up nanoprecipitation technique using microfluidic reactors. International Journal of Pharmaceutics, 375 (1-2). pp. 107-113. ISSN: 0378-5173
Seaton, Colin C. and Scowen, Ian J. and Blagden, Nicholas (2009) Formation of a hybrid coordination-molecular complex. CrystEngComm, 11 (9). pp. 1793-1795. ISSN: 1466-8033
Seaton, Colin C. and Parkin, Andrew and Wilson, Chick C. and Blagden, Nicholas (2009) Controlling the formation of benzoic acid: isonicotinamide molecular complexes. Crystal Growth and Design, 9 (1). pp. 47-56. ISSN: 1528-7483
Blagden, Nicholas and Berry, David J. and Parkin, Aandrew and Javed, Hafsa and Ibrahim, Asim and Gavan, Pauline T. and De Matos, Luciana L. and Seaton, Colin C. (2008) Current directions in co-crystal growth. New Journal of Chemistry, 32 (10). pp. 1659-1672. ISSN: 1144-0546
Berry, David J. and Seaton, Colin C. and Clegg, William and Harrington, Ross W. and Coles, Simon J. and Horton, Peter N. and Hursthouse, Michael B. and Storey, Richard and Jones, William and Friscic, Tomislav and Blagden, Nicholas (2008) Applying hot-stage microscopy to co-crystal screening: a study of nicotinamide with seven active pharmaceutical ingredients. Crystal Growth and Design, 8 (5). pp. 1697-1712. ISSN: 1528-7483
Seaton, Colin C. and Parkin, Andrew and Wilson, Chick C. and Blagden, Nicholas (2008) Growth of an organic co-crystal upon a component subphase. Crystal Growth and Design, 8 (2). pp. 363-368. ISSN: 1528-7483
Blagden, N. and de Matas, M. and Gavan, P.T. and York, P. (2007) Crystal engineering of active pharmaceutical ingredients to improve solubility and dissolution rates. Advanced Drug Delivery Reviews, 59 (7). pp. 617-630. ISSN: 0169-409X
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