个人简介

Dr Matthew Simmonds is a Senior Lecturer in Biomedical Science in College of Science whose research involves investigating genetic predictors of long-term pancreas transplant function in people with type 1 diabetes. During my PhD and early postdoctoral career at the University of Birmingham, UK, my work focused on investigating the genetic contribution to common autoimmune disease, using autoimmune thyroid disease (AITD) as a model. This provided unparalleled opportunities to learn about the genes involved in the autoimmune disease process, mechanisms behind these associations and understand how genetically similar AITD is to other autoimmune diseases, such as type 1 diabetes (T1D). To create my own unique independent research identity, I was keen to utilise the skills I gained in immunity and autoimmunity and transfer these into investigating genetic predictors of transplant function. I initially collaborated with several groups in the UK to look at genetic predictors of long-term kidney transplant function. In 2010, I moved to University of Oxford to establish from scratch my own research area investigating genetic predictors of long-term pancreas transplant function in people with type 1 diabetes. My group has been the first to identify several genetic variants within the genomes of both donors and transplant recipients which impact upon long-term pancreas graft function. I have also produced several conference presentations and senior author publications within this new area. I have now moved to the University of Lincoln to continue to enhance and expand this unique research area looking at genetic predictors of pancreas transplant function and will also be taking an active role in the excellent biosciences teaching that occurs at Lincoln. Research Career 2016- Senior Lecturer in Biomedical Science, College of Science, University of Lincoln, UK 2015-2016University Research Lecturer & Diabetes Research and Wellness Foundation (DRWF) Non-Clinical Fellow, OCDEM, University of Oxford, UK 2012-2015 Diabetes Research and Wellness Foundation (DRWF) Non-Clinical Fellow,OCDEM, University of Oxford, UK 2011-2012 European Foundation for the Study of Diabetes (EFSD)/Lilly Postdoctoral Research Fellow OCDEM, University of Oxford, UK 2010-2011 Senior Postdoctoral Research Fellow, Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), University of Oxford, UK 2005-2010 Postdoctoral Research Fellow, Centre for Endocrinology, Diabetes and Metabolism (CEDAM), University of Birmingham, UK 2001-2005 Ph.D. Student, Department of Medicine, University of Birmingham, UK Subject Specialism Transplantation, Autoimmunity, Diabetes, Autoimmune Thyroid Disease & Genetics Qualifications PhD in Genetics of Autoimmune Disease — University of Birmingham, 2004 BSc in Cell and Molecular Biology — University of Essex, 2001 Awards Award for Excellence — Univeristy of Oxford, 2014 Innovators in Diabetes Course — Diabetes UK, 2014 Professional Affiliations British Transplantation Society — Member Diabetes UK — Member Society for Endocrinology — Member

研究领域

Genetic Markers of Encapsulating Peritoneal Sclerosis Project Grant, Co-Applicant — Kidneys for Life fundraising for MINT in 2015 Role of type 1 diabetes (T1D) susceptibility genes in predicting long term pancreas transplant function in T1D patients: pilot study — Novo Nordisk UK Research Foundation Grant in 2014 Identifying genetic predictors of graft function to enable pancreas transplantation to become a lifelong cure for type 1 diabetes — Diabetes Research and Wellness Foundation (DRWF) Non-Clinical Fellowship in 2012 Extending whole pancreas transplant function in type 1 diabetics — Diabetes Research and Wellness Foundation (DRWF) Open Clinical Funding in 2012 Identifying genetic predictors of graft function in whole organ pancreas transplantation — European Foundation of the Study for Diabetes (EFSD)/Lilly Research Fellowship in 2011 Screening the HDLBP region for association with Graves’ disease — Summer studentship for undergraduate studentship: Society for Endocrinology in 2008 Sense about Science: Media Training Workshop — Society for Endocrinology in 2008 Identification of the Graves’ disease associated DNA variant located within FCRL5 — Small Grant for Scientific Research in Endocrinology: Society for Endocrinology in 2007

Autoimmune Thyroid Disease Autoimmunity Diabetes Genetics Tranplantation

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Hamilton, A. and Mittal, S. and Barnardo, M. C .N. M. and Fuggle, S. V. and Friend, P. and Gough, S. C. L. and Simmonds, M. (2015) Genetic variation in Caveolin-1 correlates with long-term pancreas transplant outcome. American Journal of Transplantation. ISSN: 1600-6143 Chand, S. and Chue, C. D. and Edwards, N. C. and Hodson, J. and Simmonds, M. J. and Hamilton, A. and Gough, S. C. L. and Harper, L. and Steeds, R. P. and Townend, J. N. and Ferro, C. J. and Borrows, R. (2015) Endothelial nitric oxide synthase single nucleotide polymorphism and left ventricular function in early chronic kidney disease. PLoS ONE, 10 (1). ISSN: 1932-6203 Hamilton, A. and Newby, P. R. and Carr-Smith, J. D. and Disanto, G. and Allahabadia, A. and Armitage, M. and Brix, T. H. and Taylor, J.C. and Vaidya, B. and Wass, J. A. and Wiersinga, W. M. and Weetman, A. P. and Ramagopalan, S. V. and Franklyn, J. A. and Gough, S. C. L. and Simmonds, M. J. (2014) Impact of month of birth on the development of autoimmune thyroid disease in the United Kingdom and Europe. Journal of Clinical Endocrinology and Metabolism, 99 (8). ISSN: 0021-972X Medici, M. and Porcu, E. and Pistis, G. and Teumer, A. and Brown, S. J. and Jensen, R. A. and Rawal, R. and Roef, G. L. and Plantinga, T. S. and Vermeulen, S. H. and Lahti, J. and Simmonds, M. J. and Husemoen, L. N. N. and Freathy, R. M. and Shields, B. M. and Pietzner, D. and Nagy, R. and Broer, L. and Chaker, L. and Korevaar, T. I. M. and Plia, M. G. and Sala, C. and Volker, U. and Richards, J. B. and Sweep, F. C. and Gieger, C. and Corre, T. and Kajantie, E. and Thuesen, B. and Taes, Y. E. and Visser, W. E. and Hattersley, A. T. and Kratzsch, J. and Hamilton, A. and Li, W. and Homuth, G. and Lobina, M. and Mariotti, S. and Soranzo, N. and Cocca, M. and Nauck, M. and Spielhagen, C. and Ross, A. and Arnold, A. and van de Bunt, M. and Liyanarachchi, S. and Heier, M. and Grabe, H. J. and Masciullo, C. and Galesloot, T. E. and Lim, E. M. and Reischl, E. and Leedman, P. J. and Lai, S. and Delitala, A. and Bremner, A. P. and Philips, D. I. W. and Beilby, J. P. and Mulas, A. and Vocale, M. and Abecasis, G. and Forsen, T. and James, A. and Widen, E. and Hui, J. and Prokisch, H. and Rietzschel, E. E. and Palotie, A. and Feddema, P. and Fletcher, S. J. and Schramm, K. and Rotter, J. I. and Kluttig, A. and Radke, D. and Traglia, M. and Surdulescu, G. L. and He, H. and Franklyn, J. A. and Tiller, D. and Vaidya, B. and de Meyer, T. and Jørgensen, T. and Eriksson, J. G. and O’Leary, P. C. and Wichmann, E. and Hermus, A. R. and Psaty, B. M. and Ittermann, T. and Hofman, A. and Bosi, E. and Schlessinger, D. and Wallaschofski, H. and Pirastu, N. and Aulchenko, Y.S. and de la Chapelle, A. and Netea-Maier, R.T. and Gough, S.C.L. and Meyer zu Schwabedissen, H. and Frayling, T.M. and Kaufman, J.M. and Linneberg, A. and Raikkonen, K. and Smit, J.W.A. and Kiemeney, L.A. and Rivadeneira, F. and Uitterlinden, A.G. and Walsh, J.P. and Meisinger, C. and den Heijer, M. and Visser, T.J. and Spector, T.D. and Wilson, S.G. and Volzke, H. and Cappola, A. and Toniolo, D. and Sanna, S. and Naitza, S. and Peeters, R.P. (2014) Identification of novel genetic loci associated with thyroid peroxidase antibodies and clinical thyroid disease. PLoS Genetics, 10 (2). ISSN: 15537390 Simmonds, M. J. and Kavvoura, F. K. and Brand, O. J. and Newby, P. R. and Jackson, L. E. and Hargreaves, C. E. and Franklyn, J. A. and Gough, S. C. L. (2014) Skewed X chromosome inactivation and female preponderance in autoimmune thyroid disease: an association study and meta-analysis. Journal of Clinical Endocrinology and Metabolism, 99 (1). ISSN: 0021-972X Chand, S. and Holle, J. U. and Hilhorst, M. and Simmonds, M. J. and Smith, S. and Kamesh, L. and Hewins, P. and McKnight, A. J. and Maxwell, A. P. and Willem Cohen Tervaert, J. and Wieczorek, S. and Harper, L. and Borrows, R. (2013) Caveolin-1 single nucleotide polymorphism in antineutrophil cytoplasmic antibody associated vasculitis. PLoS ONE, 8 (7). ISSN: 1932-6203 Hunt, K. A. and Mistry, V. and Bockett, N. A. and Ahmad, T. and Ban, M. and Barker, J. N. and Barrett, J. C. and Blackburn, H. and Brand, O. J. and Burren, O. and Capon, F. and Compston, A. and Gough, S. C. L. and Jostins, L. and Kong, Y. and Lee, J. C. and Lek, M. and MacArthur, D. G. and Mansfield, J. C. and Mathew, C. G. and Mein, C. A. and Mirza, M. and Nutland, S. and Onengut-Gumuscu, S. and Papouli, E. and Parkes, M. and Rich, S. S. and Sawcer, S. and Satsangi, J. and Simmonds, M. J. and Trembath, R. C. and Walker, N. M. and Wozniak, E. and Todd, J. A. and Simpson, M. A. and Plagnol, V. and van Heel, D. A. (2013) Negligible impact of rare autoimmune-locus coding-region variants on missing heritability. Nature, 498 (7453). pp. 232-235. ISSN: 0028-0836 Simmonds, Matthew J. and Benavente, David and Brand, Oliver J. and Moore, Jason and Ball, Simon and Ferro, Charles J. and Briggs, David and Gough, Stephen C. L. and Borrows, Richard J. (2013) Skewing of female X-chromosome inactivation: an epigenetic risk factor for kidney transplantation outcome. Transplantation, 95 (5). pp. e25-e28. ISSN: 0041-1337 Cooper, J. D. and Simmonds, M. J. and Walker, N.M. and Burren, O. and Brand, O.J. and Guo, H. and Wallace, C. and Stevens, H. and Coleman, G and Franklyn, J.A. and Todd, J.A. and Gough, S.C.L. (2012) Seven newly identified loci for autoimmune thyroid disease. Human Molecular Genetics, 21 (23). pp. 5202-5208. ISSN: 0964-6906 Moore, Jason and McKnight, Amy Jayne and Döhler, Bernd and Simmonds, Matthew J. and Courtney, Aisling E. and Brand, Oliver J. and Briggs, David and Ball, Simon and Cockwell, Paul and Patterson, Christopher C. and Maxwell, Alexander P. and Gough, Stephen C. L. and Opelz, Gerhard and Borrows, Richard (2012) Donor ABCB1 variant associates with increased risk for kidney allograft failure. Journal of the American Society of Nephrology, 23 (11). pp. 1891-1899. ISSN: 1046-6673 Hunt, K. A. and Smyth, D. J. and Balschun, T. and Ban, M. and Mistry, V. and Ahmed, T. and Barrett, J. C. and Bhaw-Rosun, L. and Bockett, N. A. and Brand, O. J. and Brouwer, E. and Concannon, P. and Cooper, J. D. and Dias, K-R. M. and van Diemen, C. C. and Dubois, P.C. and Edkins, S. and Fölster-Holst, R. and Fransen, K. and Glass, D. N. and Heap, G. A. R. and Hofmann, S. and Huizinga, T. W. J. and Hunt, S. and Langford, C. and Lee, J. and Mansfield, J. and Giovanna Marrosu, M. and Mathew, C. G. and Mein, C.A. and Müller-Quernheim, J. and Nutland, S. and Onengut-Gumuscu, S. and Ouwehand, W. and Pearce, K. and Prescott, N. and Posthumus, M. D. and Potter, S. and Rosati, G. and Sambrook, J. and Satsangi, J. and Schreiber, S. and Shtir, C. and Simmonds, M. J. and Sudman, M. and Thompson, S. D. and Toes, R. and Trynka, G. and Vyse, T. J. and Walker, N. M. and Weidinger, S. and Zhernakova, A. and Zoledziewska, M. and Weersma, R.K. and Gough, S.C.L. and Sawcer, S. and Wijmenga, C. and Parkes, M. and Cucca, F. and Franke, A. and Deloukas, P. and Rich, S. S. and Todd, J. A. and van Heel, D. A. (2011) Rare and functional SIAE variants are not associated with autoimmune disease risk in up to 66,924 individuals of European ancestry. Nature Genetics, 44 (1). pp. 3-5. ISSN: 10614036 Plagnol, Vincent and Howson, Joanna M. M. and Smyth, Deborah J. and Walker, Neil and Hafler, Jason P. and Wallace, Chris and Stevens, Helen and Jackson, Laura and Simmonds, Matthew J. and T1D Genetics Consortium, - and Bingley, Polly J. and Gough, Stephen C. and Todd, John A. (2011) Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases. PLoS Genetics, 7 (8). ISSN: 1553-7390 Simmonds, Matthew J. and Brand, Oliver J. and Barrett, Jeffrey C. and Newby, Paul R. and Franklyn, Jayne A. and Gough, Stephen C. L. (2010) Association of Fc receptor-like 5 (FCRL5) with Graves' disease is secondary to the effect of FCRL3. Clinical Endocrinology, 73 (5). pp. 654-660. ISSN: 0300-0664 Newby, Paul R. and Pickles, Oliver J. and Mazumdar, Samaresh and Brand, Oliver J. and Carr-Smith, Jacqueline D. and Pearce, Simon H. S. and Franklyn, Jayne A. and Evans, David M. and Simmonds, Matthew J. and Gough, Stephen C. L. and Welcome Trust Case-Control Consortium (WTCCC), . (2010) Follow-up of potential novel Graves' disease susceptibility loci, identified in the UK WTCCC genome-wide nonsynonymous SNP study. European Journal of Human Genetics, 18 (9). pp. 1021-1026. ISSN: 1018-4813 Buckham, T. A. and McKnight, A. J. and Benevente, D. and Courtney, A. E. and Patterson, C. C. and Simmonds, Matthew J. and Gough, S. C. L. and Middleton, D. and Borrows, R. and Maxwell, A. P. (2010) Evaluation of five interleukin genes for association with end-stage renal disease in white Europeans. American Journal of Nephrology, 32 (2). pp. 103-108. ISSN: 0250-8095 Yesmin, K. and Hargreaves, C. and Newby, P. R. and Brand, O. J. and Heward, J. M. and Franklyn, J. A. and Gough, S. C. L. and Simmonds, M. J. (2010) Association of FcGRIIa with Graves' disease: a potential role for dysregulated autoantibody clearance in disease onset/progression. Clinical Endocrinology, 73 (1). pp. 119-125. ISSN: 0300-0664 Moore, J. and McKnight, A.J. and Simmonds, M. J. and Courtney, A. E. and Hanvesakul, R. and Brand, O. J. and Briggs, D. and Ball, S. and Cockwell, P. and Patterson, C.C. and Maxwell, A. P. and Gough, S. C. L. and Borrows, R. (2010) Association of caveolin-1 gene polymorphism with kidney transplant fibrosis and allograft failure. JAMA - Journal of the American Medical Association, 303 (13). pp. 1282-1287. ISSN: 0098-7484 Simmonds, Matthew J. and Yesmin, Kadja and Newby, Paul R. and Brand, Oliver J. and Franklyn, Jayne A. and Gough, Stephen C. L. (2010) Confirmation of association of chromosome 5q31-33 with United Kingdom caucasian Graves' disease. Thyroid, 20 (4). pp. 413-417. ISSN: 1050-7256 Craddock, Nick and Hurles, Matthew E. and Cardin, Niall and Pearson, Richard D. and Plagnol, Vincent and Robson, Samuel and Vukcevic, Damjan and Barnes, Chris and Conrad, Donald F. and Giannoulatou, Eleni and Holmes, Chris and Marchini, Jonathan L. and Stirrups, Kathy and Tobin, Martin D. and Wain, Louise V. and Yau, Chris and Aerts, Jan and Ahmad, Tariq and Daniel Andrews, T. and Arbury, Hazel and Attwood, Anthony and Auton, Adam and Ball, Stephen G. and Balmforth, Anthony J. and Barrett, Jeffrey C. and Barroso, Inês and Barton, Anne and Bennett, Amanda J. and Bhaskar, Sanjeev and Blaszczyk, Katarzyna and Bowes, John and Brand, Oliver J. and Braund, Peter S. and Bredin, Francesca and Breen, Gerome and Brown, Morris J. and Bruce, Ian N. and Bull, Jaswinder and Burren, Oliver S. and Burton, John and Byrnes, Jake and Caesar, Sian and Clee, Chris M. and Coffey, Alison J. and Connell, John M. C. and Cooper, Jason D. and Dominiczak, Anna F. and Downes, Kate and Drummond, Hazel E. and Dudakia, Darshna and Dunham, Andrew and Ebbs, Bernadette and Eccles, Diana and Edkins, Sarah and Edwards, Cathryn and Elliot, Anna and Emery, Paul and Evans, David M. and Evans, Gareth and Eyre, Steve and Farmer, Anne and Nicol Ferrier, I. and Feuk, Lars and Fitzgerald, Tomas and Flynn, Edward and Forbes, Alistair and Forty, Liz and Franklyn, Jayne A. and Freathy, Rachel M. and Gibbs, Polly and Gilbert, Paul and Gokumen, Omer and Gordon-Smith, Katherine and Gray, Emma and Green, Elaine and Groves, Chris J. and Grozeva, Detelina and Gwilliam, Rhian and Hall, Anita and Hammond, Naomi and Hardy, Matt and Harrison, Pile and Hassanali, Neelam and Hebaishi, Husam and Hines, Sarah and Hinks, Anne and Hitman, Graham A and Hocking, Lynne and Howard, Eleanor and Howard, Philip and Howson, Joanna M. M. and Hughes, Debbie and Hunt, Sarah and Isaacs, John D. and Jain, Mahim and Jewell, Derek P. and Johnson, Toby and Jolley, Jennifer D. and Jones, Ian R. and Jones, Lisa A. and Kirov, George and Langford, Cordelia F. and Lango-Allen, Hana and Mark Lathrop, G. and Lee, James and Lee, Kate L. and Lees, Charlie and Lewis, Kevin and Lindgren, Cecilia M. and Maisuria-Armer, Meeta and Maller, Julian and Mansfield, John and Martin, Paul and Massey, Dunecan C. O. and McArdle, Wendy L. and McGuffin, Peter and McLay, Kirsten E. and Mentzer, Alex and Mimmack, Michael L. and Morgan, Ann E. and Morris, Andrew P. and Mowat, Craig and Myers, Simon and Newman, William and Nimmo, Elaine R. and O’Donovan, Michael C. and Onipinla, Abiodun and Onyiah, Ifejinelo and Ovington, Nigel R. and Owen, Michael J. and Palin, Kimmo and Parnell, Kirstie and Pernet, David and Perry, John R. B. and Phillips, Anne and Pinto, Dalila and Prescott, Natalie J. and Prokopenko, Inga and Quail, Michael A. and Rafelt, Suzanne and Rayner, Nigel W. and Redon, Richard and Reid, David M. and Renwick, Anthony and Ring, Susan M. and Robertson, Neil and Russell, Ellie and St Clair, David and Sambrook, Jennifer G. and Sanderson, Jeremy D. and Schuilenburg, Helen and Scott, Carol E. and Scott, Richard and Seal, Sheila and Shaw-Hawkins, Sue and Shields, Beverley M. and Simmonds, Matthew J. and Smyth, Debbie J. and Somaskantharajah, Elilan and Spanova, Katarina and Steer, Sophia and Stephens, Jonathan and Stevens, Helen E. and Stone, Millicent A. and Su, Zhan and Symmons, Deborah P. M. and Thompson, John R. and Thomson, Wendy and Travers, Mary E. and Turnbull, Clare and Valsesia, Armand and Walker, Mark and Walker, Neil M. and Wallace, Chris and Warren-Perry, Margaret and Watkins, Nicholas A. and Webster, John and Weedon, Michael N. and Wilson, Anthony G. and Woodburn, Matthew and Wordsworth, B. Paul and Young, Allan H. and Zeggini, Eleftheria and Carter, Nigel P. and Frayling, Timothy M. and Lee, Charles and McVean, Gil and Munroe, Patricia B. and Palotie, Aarno and Sawcer, Stephen J. and Scherer, Stephen W. and Strachan, David P. and Tyler-Smith, Chris and Brown, Matthew A. and Burton, Paul R. and Caulfield, Mark J. and Compston, Alastair and Farrall, Martin and Gough, Stephen C. L. and Hall, Alistair S. and Hattersley, Andrew T. and Hill, Adrian V. S. and Mathew, Christopher G. and Pembrey, Marcus and Satsangi, Jack and Stratton, Michael R. and Worthington, Jane and Deloukas, Panos and Duncanson, Audrey and Kwiatkowski, Dominic P. and McCarthy, Mark I. and Ouwehand, Willem H. and Parkes, Miles and Rahman, Nazneen and Todd, John A. and Samani, Nilesh J. and Donnelly, Peter (2010) Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls. Nature, 464 (7289). pp. 713-720. ISSN: 0028-0836 Boelaert, Kristien and Newby, Paul R. and Simmonds, Matthew J. and Holder, Roger L. and Carr-Smith, Jacqueline D. and Heward, Joanne M. and Manji, Nilusha and Allahabadia, Amit and Armitage, Mary and Chatterjee, Krishna V. and Lazarus, John H. and Pearce, Simon H. and Vaidya, Bijay and Gough, Stephen C. and Franklyn, Jayne A. (2010) Prevalence and relative risk of other autoimmune diseases in subjects with autoimmune thyroid disease. American Journal of Medicine, 123 (2). pp. 183.e1-183.e9. ISSN: 0002-9343 Wood, Alice M. and Needham, Michelle and Simmonds, Matthew J. and Newby, Paul R. and Gough, Stephen C. and Stockley, Robert A. (2009) Phenotypic differences in alpha 1 antitrypsin-deficient sibling pairs may relate to genetic variation. COPD: Journal of Chronic Obstructive Pulmonary Disease, 5 (6). pp. 353-359. ISSN: 1541-2555 Brand, O. J. and Barrett, J. C. and Simmonds, M. J. and Newby, P. R. and McCabe, C. J. and Bruce, C. K. and Kysela, B. and Carr-Smith, J. D. and Brix, T. and Hunt, P. J. and Wiersinga, W. M. and Hegedus, L. and Connell, J. and Wass, J. A. H. and Franklyn, J. A. and Weetman, A. P. and Heward, J. M. and Gough, S. C. L. (2009) Association of the thyroid stimulating hormone receptor gene (TSHR) with Graves' disease. Human Molecular Genetics, 18 (9). pp. 1704-1713. ISSN: 0964-6906 Hafler, J. P. and Maier, L. M. and Cooper, J. D. and Plagnol, V. and Hinks, A. and Simmonds, M. J. and Stevens, H. and Walker, N. and Healy, B. and Howson, J. M. M. and Maisuria, M. and Duley, S. and Coleman, G. and Gough, S. C. L. and Worthington, J. and Kuchroo, V. K. and Wicker, L. S. and Todd, J. A. and IMSGC, . (2009) CD226 Gly307Ser association with multiple autoimmune diseases. Genes and Immunity, 10 (1). pp. 5-10. ISSN: 1466-4879 Wood, Alice M. and Simmonds, Matthew J. and Bayley, Darren L. and Newby, Paul R. and Gough, Stephen C. and Stockley, Robert A. (2008) The TNFalpha gene relates to clinical phenotype in alpha-1-antitrypsin deficiency. Respiratory Research, 9 (52). ISSN: 1465-9921 Zeitlin, A. A. and Heward, J. M. and Newby, P. R. and Carr-Smith, J. D. and Franklyn, J. A. and Gough, S. C. L. and Simmonds, M. J. (2008) Analysis of HLA class II genes in Hashimoto's thyroiditis reveals differences compared to Graves' disease. Genes and Immunity, 9 (4). pp. 358-363. ISSN: 1466-4879