Flint, James - University of Lincoln - School of Life Sciences

个人简介

James Flint is a Lecturer in College of Science Department Responsibilities Programme Leader for MSc Biotechnology Module Leader for Introduction to Biotechnology (BGY9002M) Module Leader for Molecular Biotechnology (BGY9003M) Module Leader for Industrial and Environmental Biotechnology (BGY9006M) Module Leader for MSc Biotechnology Research Projects (BGY9009M) Module Leader for Biotechnology (BIO3103M) Subject Specialism Biotechnology, Molecular Biology, Biochemistry Qualifications PhD — University of Newcastle, 2004 MSc Applied Molecular Microbiology — University of Nottingham, 2000 BSc Genetics and Microbiology — University of Sheffield, 1995

近期论文

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Cuskin, Fiona and Flint, James E. and Gloster, Tracey M. and Morland, Carl and Basle, Arnaud and Henrissat, Bernard and Coutinho, Pedro M. and Strazzulli, Andrea and Solovyova, Alexandra S. and Davies, Gideon J. and Gilbert, Harry J. (2012) How nature can exploit nonspecific catalytic and carbohydrate binding modules to create enzymatic specificity. Proceedings of the National Academy of Sciences, 109 (51). pp. 20889-20894. ISSN: 0027-8424 Montanier, C. Y. and Correia, M. A. S. and Flint, J. E. and Zhu, Y. and BaslÃ�ï¿½Ã�Â©, A. and McKee, L. S. and Prates, J. A. M. and Polizzi, S. and Coutinho, P. M. and Lewis, R. J. and Henrissat, B. and Fontes, C. M. G. A. and Gilbert, H. J. (2011) A novel, noncatalytic carbohydrate-binding module displays specificity for galactose-containing polysaccharides through calcium-mediated oligomerization. Journal of Biological Chemistry, 286 (25). pp. 22499-22509. ISSN: 0021-9258 Montanier, Cedric and Flint, James E. and Bolam, David N. and Xie, Hefang and Liu, Ziyuan and Rogowski, Artur and Weiner, David P. and Ratnaparkhe, Supriya and Nurizzo, Didier and Roberts, Shirley M. and Turkenburg, Johan P. and Davies, Gideon J. and Gilbert, Harry J. (2010) Circular permutation provides an evolutionary link between two families of calcium-dependent carbohydrate binding modules. The Journal of Biological Chemistry, 285 (41). pp. 31742-31754. ISSN: 0021-9258 Correia, MaÃ�ï¿½rcia A. S. and Abbott, D. Wade and Gloster, Tracey M. and Fernandes, VaÃ�ï¿½nia O. and Prates, JoseÃ�ï¿½ A. M. and Montanier, Cedric and Dumon, Claire and Williamson, Michael P. and Tunnicliffe, Richard B. and Liu, Ziyuan and Flint, James E. and Davies, Gideon J. and Henrissat, Bernard and Coutinho, Pedro M. and Fontes, Carlos M. G. A. and Gilbert, Harry J. (2010) Signature active site architectures illuminate the molecular basis for ligand specificity in family 35 carbohydrate binding module. Biochemistry, 49 (29). pp. 6193-6205. ISSN: 0006-2960 Tailford, Louise E. and Ducros, Valerie M.-A. and Flint, James E. and Roberts, Shirley M. and Morland, Carl and Zechel, David L. and Smith, Nicola and Bjornvad, Mads E. and Borchert, Torben V. and Wilson, Keith S. and Davies, Gideon J. and Gilbert, Harry J. (2009) Understanding how diverse β-mannanases recognize heterogeneous substrates. Biochemistry, 48 (29). pp. 7009-7018. ISSN: 0006-2960 Leung, W. C. and Hessel, S. and Meplan, C. and Flint, J. and Oberhauser, V. and Tourniaire, F. and Hesketh, J. E. and Von Lintig, J. and Lietz, G. (2009) Two common single nucleotide polymorphisms in the gene encoding β-carotene 15,15′-monoxygenase alter β-carotene metabolism in female volunteers. FASEB Journal, 23 (4). pp. 1041-1053. ISSN: 0892-6638 Montanier, Cedric and Money, Victoria A. and Pires, Virginia M. R. and Flint, James E. and Pinheiro, Benedita A. and Goyal, Arun and Prates, Jose A. M. and Izumi, Atsushi and Stalbrand, Henrik and Morland, Carl and Cartmell, Alan and Kolenova, Katarina and Topakas, Evangelos and Dodson, Eleanor J. and Bolam, David N. and Davies, Gideon J. and Fontes, Carlos M. G. A. and Gilbert, Harry J. (2009) The active site of a carbohydrate esterase displays divergent catalytic and noncatalytic binding functions. PLoS Biology, 7 (3). pp. e1000071. ISSN: 1544-9173 Montanier, Cedric and Van Bueren, Alicia Lammerts and Dumon, Claire and Flint, James E. and Correia, Marcia A. and Prates, Jose A. and Firbank, Susan J. and Lewis, Richard J. and Grondin, Gilles G. and Ghinet, Mariana G. and Gloster, Tracey M. and Herve, Cecile and Knox, J. Paul and Talbot, Brian G. and Turkenburg, Johan P. and Kerovuo, Janne and Brzezinski, Ryszard and Fontes, Carlos M. G. A. and Davies, Gideon J. and Boraston, Alisdair B. and Gilbert, Harry J. (2009) Evidence that family 35 carbohydrate binding modules display conserved specificity but divergent function. Proceedings of the National Academy of Sciences, 106 (9). pp. 3065-3070. ISSN: 0027-8424 Dumon, Claire and Varvak, Alexander and Wall, Mark A. and Flint, James E. and Lewis, Richard J. and Lakey, Jeremy H. and Morland, Carl and Luginbuhl, Peter and Healey, Shaun and Todaro, Thomas and DeSantis, Grace and Sun, May and Parra-Gessert, Lilian and Tan, Xuqiu and Weiner, David P. and Gilbert, Harry J. (2008) Engineering hyperthermostability into a GH11 xylanase is mediated by subtle changes to protein structure. The Journal of biological chemistry, 283 (33). pp. 22557-22564. ISSN: 0021-9258 Correia, Marcia A. S. and Prates, Jose A. M. and Bras, Joana and Fontes, Carlos M. G. A. and Newman, Joseph A. and Lewis, Richard J. and Gilbert, Harry J. and Flint, James E. (2008) Crystal structure of a cellulosomal family 3 carbohydrate esterase from Clostridium thermocellum provides Insights into the mechanism of substrate recognition. Journal of Molecular Biology, 379 (1). pp. 64-72. ISSN: 0022-2836 Vardakou, Maria and Dumon, Claire and Murray, James W. and Christakopoulos, Paul and Weiner, David P. and Juge, Nathalie and Lewis, Richard J. and Gilbert, Harry J. and Flint, James E. (2008) Understanding the structural basis for substrate and inhibitor recognition in eukaryotic GH11 xylanases. Journal of Molecular Biology, 375 (5). pp. 1293-1305. ISSN: 0022-2836 Blake, Anthony W. and McCartney, Lesley and Flint, James E. and Bolam, David N. and Boraston, Alisdair B. and Gilbert, Harry J. and Knox, J. Paul (2006) Understanding the biological rationale for the diversity of cellulose-directed carbohydrate-binding modules in prokaryotic enzymes. Journal of Biological Chemistry, 281 (39). pp. 29321-29329. ISSN: 0021-9258 Xie, Hefang and Flint, James and Vardakou, Maria and Lakey, Jeremy H. and Lewis, Richard J. and Gilbert, Harry J. and Dumon, Claire (2006) Probing the structural basis for the difference in thermostability displayed by family 10 xylanases. Journal of Molecular Biology, 360 (1). pp. 157-167. ISSN: 0022-2836 McCartney, Lesley and Blake, Anthony W. and Flint, James and Bolam, David N. and Boraston, Alisdair B. and Gilbert, Harry J. and Knox, J.Paul (2006) Differential recognition of plant cell walls by microbial xylan-specific carbohydrate-binding modules. Proceedings of the National Academy of Sciences of the United States of America, 103 (12). pp. 4765-4770. ISSN: 0027-8424 Vardakou, Maria and Flint, James and Christakopoulos, Paul and Lewis, Richard J. and Gilbert, Harry J. and Murray, James W. (2005) A family 10 Thermoascus aurantiacus xylanase utilizes arabinose decorations of xylan as significant substrate specificity determinants. Journal of Molecular Biology, 352 (5). pp. 1060-1067. ISSN: 0022-2836 Flint, James and Bolam, DAvid N. and Nurizzo, Didier and Taylor, Edward J. and Williamson, Michael P. and Walters, Christopher and Davies, Gideon J. and Gilbert, Harry J. (2005) Probing the mechanism of ligand recognition in family 29 carbohydrate-binding modules. The Journal of Biological Chemistry, 280 (25). pp. 23718-23726. ISSN: 0021-9258 Flint, James and Nurizzo, Didier and Harding, Stephen E. and Longman, Emma and Davies, Gideon J. and Gilbert, Harry J. and Bolam, David N. (2004) Ligand-mediated dimerization of a carbohydrate-binding module reveals a novel mechanism for protein-carbohydrate recognition. Journal of Molecular Biology, 337 (2). pp. 417-426. ISSN: 0022-2836