Bevan, Stephen - University of Lincoln - School of Life Sciences

个人简介

Steve Bevan graduated from the University of Portsmouth with first class honours in 1994 and subsequently obtained his PhD from the University of London in 1998, specialising in genetics. A 5 year position as a post-doc and senior post-doc in cancer genetics at the Institute of Cancer Research (1997-2003) led to tenure at St George’s, University of London (2003-2013). Steve progressed from Lecturer to Senior Lecturer and then to Reader in Cerebrovascular Genetics at St George’s. During this time he developed interests in research, education, management and career development; held the role of Associate Dean for Career Development of Contract Research Staff; and developed a Postgraduate Certificate in Research Skills for research staff, acting as Course Director of the PGCRS. This was followed by a move to Cambridge as a Principal Research Associate (2013-2015) and the most recent move to the University of Lincoln as Deputy Head of the School of Life Science (2015). Currently combining research, teaching and management, Steve has a number of roles at Lincoln including Director of Education for the School of Life Sciences and chairing the Schools Learning, Teaching and Assessment Committee. Department Responsibilities University of Lincoln Radiation Safety Committee - Chair College of Science Academic Affairs Committee (COSAAC) - Member School of Life Sciences - Director of Education School of Life Sciences Learning, Teaching and Assessment Committee (LTAC) - Chair School of Life Sciences Management Committee - Member School of Life Sciences Genetically Modified Organism (GMO) Committee - Member Subject Specialism Genetics, genetic analysis, complex disease genetics Qualifications PGCert Healthcare Education — St George’s, University of London, 2007 PhD — University of London, 1998 BSc Biology (Ist Class) Hons — University of Portsmouth, 1994 External Activities and Consultancy National Medical Research Council, Singapore - Expert International Member International Stroke Genetics Consortium (ISGC) - Steering Committee Member METASTROKE Consortium - Member

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Prins, Bram P. and Abbasi, Ali and Wong, Anson and Vaez, Ahmad and Nolte, Ilja and Franceschini, Nora and Stuart, Philip E. and Guterriez Achury, Javier and Mistry, Vanisha and Bradfield, Jonathan P. and Valdes, Ana M. and Bras, Jose and Shatunov, Aleksey and Lu, Chen and Han, Buhm and Raychaudhuri, Soumya and Bevan, Steve and Mayes, Maureen D. and Tsoi, Lam C. and Evangelou, Evangelos and Nair, Rajan P. and Grant, Struan F. A. and Polychronakos, Constantin and Radstake, Timothy R. D. and van Heel, David A. and Dunstan, Melanie L. and Wood, Nicholas W. and Al-Chalabi, Ammar and Dehghan, Abbas and Hakonarson, Hakon and Markus, Hugh S. and Elder, James T. and Knight, Jo and Arking, Dan E. and Spector, Timothy D. and Koeleman, Bobby P. C. and van Duijn, Cornelia M. and Martin, Javier and Morris, Andrew P. and Weersma, Rinse K. and Wijmenga, Cisca and Munroe, Patricia B. and Perry, John R. B. and Pouget, Jennie G. and Jamshidi, Yalda and Snieder, Harold and Alizadeh, Behrooz Z. (2016) Investigating the causal relationship of C-reactive protein with 32 complex somatic and psychiatric outcomes: a large-scale cross-consortium Mendelian randomization study. PLoS medicine, 13 (6). pp. e1001976. ISSN: 1549-1277 Traylor, Matthew and Rutten-Jacobs, Loes C. A. and Thijs, Vincent and Holliday, Elizabeth G. and Levi, Chris and Bevan, Steve and Malik, Rainer and Boncoraglio, Giorgio and Sudlow, Cathie and Rothwell, Peter M. and Dichgans, Martin and Markus, Hugh S. (2016) Genetic associations with white matter hyperintensities confer risk of lacunar stroke. Stroke: a Journal of Cerebral Circulation, 47 (5). pp. 1174-9. ISSN: 0039-2499 Malik, Rainer and Traylor, Matthew and Pulit, Sara L. and Bevan, Steve and Hopewell, Jemma C. and Holliday, Elizabeth G. and Zhao, Wei and Abrantes, Patricia and Amouyel, Philippe and Attia, John R. and Battey, Thomas W. K. and Berger, Klaus and Boncoraglio, Giorgio B. and Chauhan, Ganesh and Cheng, Yu-Ching and Chen, Wei-Min and Clarke, Robert and Cotlarciuc, Ioana and Debette, Stephanie and Falcone, Guido J. and Ferro, Jose M. and Gamble, Dale M. and Ilinca, Andreea and Kittner, Steven J. and Kourkoulis, Christina E. and Lemmens, Robin and Levi, Christopher R. and Lichtner, Peter and Lindgren, Arne and Liu, Jingmin and Meschia, James F. and Mitchell, Braxton D. and Oliveira, Sofia A. and Pera, Joana and Reiner, Alex P. and Rothwell, Peter M. and Sharma, Pankaj and Slowik, Agnieszka and Sudlow, Cathie L. M. and Tatlisumak, Turgut and Thijs, Vincent and Vicente, Astrid M. and Woo, Daniel and Seshadri, Sudha and Saleheen, Danish and Rosand, Jonathan and Markus, Hugh S. and Worrall, Bradford B. and Dichgans, Martin (2016) Low-frequency and common genetic variation in ischemic stroke: The METASTROKE collaboration. Neurology, 86 (13). pp. 1217-1226. ISSN: 0028-3878 Seppälä, Ilkka and Kleber, Marcus E. and Bevan, Steve and Lyytikäinen, Leo-Pekka and Oksala, Niku and Hernesniemi, Jussi A. and Mäkelä, Kari-Matti and Rothwell, Peter M. and Sudlow, Cathie and Dichgans, Martin and Mononen, Nina and Vlachopoulou, Efthymia and Sinisalo, Juha and Delgado, Graciela E. and Laaksonen, Reijo and Koskinen, Tuomas and Scharnagl, Hubert and Kähönen, Mika and Markus, Hugh S. and März, Winfried and Lehtimäki, Terho (2016) Associations of functional alanine-glyoxylate aminotransferase 2 gene variants with atrial fibrillation and ischemic stroke. Scientific Reports, 6. pp. 23207. ISSN: 2045-2322 Rutten-Jacobs, Loes C. A. and Traylor, Matthew and Adib-Samii, Poneh and Thijs, Vincent and Sudlow, Cathie and Rothwell, Peter M. and Boncoraglio, Giorgio and Dichgans, Martin and Meschia, James and Maguire, Jane and Levi, Christopher and Rost, Natalia S. and Rosand, Jonathan and Hassan, Ahamad and Bevan, Steve and Markus, Hugh S. (2016) Association of MTHFR C677T genotype with ischemic stroke is confined to cerebral small vessel disease subtype. Stroke: a Journal of Cerebral Circulation, 47 (3). pp. 646-651. ISSN: 0039-2499 Harris, Sarah E. and Malik, Rainer and Marioni, Riccardo and Campbell, Archie and Seshadri, Sudha and Worrall, Bradford B. and Sudlow, Cathie L. M. and Hayward, Caroline and Bastin, Mark E. and Starr, John M. and Porteous, David J. and Wardlaw, Joanna M. and Deary, Ian J. and METASTROKE Consortium, . (2016) Polygenic risk of ischemic stroke is associated with cognitive ability. Neurology, 86 (7). pp. 611-618. ISSN: 0028-3878 Cheng, Yu-Ching and Stanne, Tara M. and Giese, Anne-Katrin and Ho, Weang Kee and Traylor, Matthew and Amouyel, Philippe and Holliday, Elizabeth G. and Malik, Rainer and Xu, Huichun and Kittner, Steven J. and Cole, John W. and O'Connell, Jeffrey R. and Danesh, John and Rasheed, Asif and Zhao, Wei and Engelter, Stefan and Grond-Ginsbach, Caspar and Kamatani, Yoichiro and Lathrop, Mark and Leys, Didier and Thijs, Vincent and Metso, Tiina M and Tatlisumak, Turgut and Pezzini, Alessandro and Parati, Eugenio A and Norrving, Bo and Bevan, Steve and Rothwell, Peter M. and Sudlow, Cathie and Slowik, Agnieszka and Lindgren, Arne and Walters, Matthew R. and Jannes, Jim and Shen, Jess and Crosslin, David and Doheny, Kimberly and Laurie, Cathy C. and Kanse, Sandip M. and Bis, Joshua C. and Fornage, Myriam and Mosley, Thomas H. and Hopewell, Jemma C. and Strauch, Konstantin and Müller-Nurasyid, Martina and Gieger, Christian and Waldenberger, Melanie and Peters, Annette and Meisinger, Christine and Ikram, M Arfan and Longstreth, W. T. and Meschia, James F. and Seshadri, Sudha and Sharma, Pankaj and Worrall, Bradford and Jern, Christina and Levi, Christopher and Dichgans, Martin and Boncoraglio, Giorgio B. and Markus, Hugh S. and Debette, Stephanie and Rolfs, Arndt and Saleheen, Danish and Mitchell, Braxton D. (2016) Genome-wide association analysis of young-onset stroke identifies a locus on chromosome 10q25 near HABP2. Stroke: a Journal of Cerebral Circulation, 47 (2). pp. 307-16. ISSN: 0039-2499 Traylor, Matthew and Anderson, Christopher D. and Hurford, Robert and Bevan, Steve and Markus, Hugh S. (2016) Oxidative phosphorylation and lacunar stroke: genome-wide enrichment analysis of common variants. Neurology, 86 (2). pp. 141-145. ISSN: 0028-3878 Traylor, Matthew and Zhang, Cathy R. and Adib-Samii, Poneh and Devan, William J. and Parsons, Owen E. and Lanfranconi, Silvia and Gregory, Sarah and Cloonan, Lisa and Falcone, Guido J. and Radmanesh, Farid and Fitzpatrick, Kaitlin and Kanakis, Allison and Barrick, Thomas R. and Moynihan, Barry and Lewis, Cathryn M. and Boncoraglio, Giorgio B. and Lemmens, Robin and Thijs, Vincent and Sudlow, Cathie and Wardlaw, Joanna and Rothwell, Peter M. and Meschia, James F. and Worrall, Bradford B. and Levi, Christopher and Bevan, Steve and Furie, Karen L. and Dichgans, Martin and Rosand, Jonathan and Markus, Hugh S. and Rost, Natalia (2016) Genome-wide meta-analysis of cerebral white matter hyperintensities in patients with stroke. Neurology, 86 (2). pp. 146-153. ISSN: 0028-3878 Gesierich, Benno and Opherk, Christian and Rosand, Jonathan and Gonik, Mariya and Malik, Rainer and Jouvent, Eric and Hervé, Dominique and Adib-Samii, Poneh and Bevan, Steve and Pianese, Luigi and Silvestri, Serena and Dotti, Maria T. and De Stefano, Nicola and van der Grond, Jeroen and Boon, Elles M. J. and Pescini, Francesca and Rost, Natalia and Pantoni, Leonardo and Lesnik Oberstein, Saskia A. and Federico, Antonio and Ragno, Michele and Markus, Hugh S. and Tournier-Lasserve, Elisabeth and Chabriat, Hugues and Dichgans, Martin and Duering, Marco and Ewers, Michael (2016) APOE ɛ2 is associated with white matter hyperintensity volume in CADASIL. Journal of Cerebral Blood Flow & Metabolism. ISSN: 0271-678X Hanscombe, Ken B. and Traylor, Matthew and Hysi, Pirro G. and Bevan, Stephen and Dichgans, Martin and Rothwell, Peter M. and Worrall, Bradford B. and Seshadri, Sudha and Sudlow, Cathie and Williams, Frances M. K. and Markus, Hugh S. and Lewis, Cathryn M. (2015) Genetic factors influencing coagulation factor XIII B-subunit contribute to risk of ischemic stroke. Stroke, 46 (8). pp. 2069-2074. ISSN: 0039-2499 Rutten-Jacobs, Loes C.A. and Traylor, Matthew and Adib-Samii, Poneh and Thijs, Vincent and Sudlow, Cathie and Rothwell, Peter M. and Boncoraglio, Giorgio and Dichgans, Martin and Bevan, Steve and Meschia, James and Levi, Christopher and Rost, Natalia S. and Rosand, Jonathan and Hassan, Ahamad and Markus, Hugh S. (2015) Common NOTCH3 variants and cerebral small-vessel disease. Stroke, 46 (6). pp. 1482-1487. ISSN: 0039-2499 Traylor, Matthew and Rutten-Jacobs, Loes C. A. and Holliday, Elizabeth G. and Malik, Rainer and Sudlow, Cathie and Rothwell, Peter M. and Maguire, Jane M. and Koblar, Simon A. and Bevan, Steve and Boncoraglio, Giorgio and Dichgans, Martin and Levi, Chris and Lewis, Cathryn M. and Markus, Hugh S. (2015) Differences in common genetic predisposition to ischemic stroke by age and sex. Stroke: a journal of cerebral circulation, 46 (11). pp. 3042-7. ISSN: 0039-2499 Traylor, Matthew and Bevan, Stephen and Baron, Jean-Claude and Hassan, Ahamad and Lewis, Cathryn M. and Markus, Hugh S. (2015) Genetic architecture of lacunar stroke. Stroke; a journal of cerebral circulation, 46 (9). pp. 2407-2412. ISSN: 0039-2499 Kilarski, Laura L. and Rutten-Jacobs, Loes C. A. and Bevan, Stephen and Baker, Rob and Hassan, Ahamad and Hughes, Derralynn A. and Markus, Hugh S. (2015) Prevalence of CADASIL and Fabry disease in a cohort of MRI defined younger onset lacunar stroke. PloS one, 10 (8). pp. e0136352. ISSN: 1932-6203 Rannikmae, K. and Davies, G. and Thomson, P. A. and Bevan, S. and Devan, W. J. and Falcone, G. J. and Traylor, M. and Anderson, C. D. and Battey, T. W. K. and Radmanesh, F. and Deka, R. and Woo, J. G. and Martin, L. J. and Jimenez-Conde, J. and Selim, M. and Brown, D. L. and Silliman, S. L. and Kidwell, C. S. and Montaner, J. and Langefeld, C. D. and Slowik, A. and Hansen, B. M. and Lindgren, A. G. and Meschia, J. F. and Fornage, M. and Bis, J. C. and Debette, S. and Ikram, M. A. and Longstreth, W. T. and Schmidt, R. and Zhang, C. R. and Yang, Q. and Sharma, P. and Kittner, S. J. and Mitchell, B. D. and Holliday, E. G. and Levi, C. R. and Attia, J. and Rothwell, P. M. and Poole, D. L. and Boncoraglio, G. B. and Psaty, B. M. and Malik, R. and Rost, N. and Worrall, B. B. and Dichgans, M. and Van Agtmael, T. and Woo, D. and Markus, H. S. and Seshadri, S. and Rosand, J. and Sudlow, C. L. M. (2015) Common variation in COL4A1/COL4A2 is associated with sporadic cerebral small vessel disease. Neurology, 84 (9). pp. 918-926. ISSN: 0028-3878 Adib-Samii, Poneh and Devan, William and Traylor, Matthew and Lanfranconi, Silvia and Zhang, Cathy R. and Cloonan, Lisa and Falcone, Guido J. and Radmanesh, Farid and Fitzpatrick, Kaitlin and Kanakis, Allison and Rothwell, Peter M. and Sudlow, Cathie and Boncoraglio, Giorgio B. and Meschia, James F. and Levi, Chris and Dichgans, Martin and Bevan, Steve and Rosand, Jonathan and Rost, Natalia S. and Markus, Hugh S. (2015) Genetic architecture of white matter hyperintensities differs in hypertensive and nonhypertensive ischemic stroke. Stroke, 46 (2). pp. 348-353. ISSN: 0039-2499 Holliday, Elizabeth G. and Traylor, Matthew and Malik, Rainer and Bevan, Stephen and Maguire, Jane and Koblar, Simon A. and Sturm, Jonathan and Hankey, Graeme J. and Oldmeadow, Christopher and McEvoy, Mark and Sudlow, Cathie and Rothwell, Peter M. and Coresh, Josef and Hamet, Pavel and Tremblay, Johanne and Turner, Stephen T. and de Andrade, Mariza and Rao, Madhumathi and Schmidt, Reinhold and Crick, Peter A. and Robino, Antonietta and Peralta, Carmen A. and Jukema, J. Wouter and Mitchell, Paul and Rosas, Sylvia E. and Wang, Jie Jin and Scott, Rodney J. and Dichgans, Martin and Mitchell, Braxton D. and Kao, W.H. Linda and Fox, Caroline S. and Levi, Christopher and Attia, John and Markus, Hugh S. (2014) Polygenic overlap between kidney function and large artery atherosclerotic stroke. Stroke, 45 (12). pp. 3508-3513. ISSN: 0039-2499 Markus, Hugh S. and Bevan, Steve (2014) Mechanisms and treatment of ischaemic stroke: insights from genetic associations. Nature Reviews Neurology, 10 (12). pp. 723-730. ISSN: 1759-4758 Kilarski, L. L. and Achterberg, S. and Devan, W. J. and Traylor, M. and Malik, R. and Lindgren, A. and Pare, G. and Sharma, P. and Slowik, A. and Thijs, V. and Walters, M. and Worrall, B. B. and Sale, M. M. and Algra, A. and Kappelle, L. J. and Wijmenga, C. and Norrving, B. and Sandling, J. K. and Ronnblom, L. and Goris, A. and Franke, A. and Sudlow, C. and Rothwell, P. M. and Levi, C. and Holliday, E. G. and Fornage, M. and Psaty, B. and Gretarsdottir, S. and Thorsteinsdottir, U. and Seshadri, S. and Mitchell, B. D. and Kittner, S. and Clarke, R. and Hopewell, J. C. and Bis, J. C. and Boncoraglio, G. B. and Meschia, J. and Ikram, M. A. and Hansen, B. M. and Montaner, J. and Thorleifsson, G. and Stefanson, K. and Rosand, J. and de Bakker, P. I. W. and Farrall, M. and Dichgans, M. and Markus, H. S. and Bevan, S. (2014) Meta-analysis in more than 17,900 cases of ischemic stroke reveals a novel association at 12q24.12. Neurology, 83 (8). pp. 678-685. ISSN: 0028-3878 Frayling, Timothy M. and Traylor, Matthew and Mäkelä, Kari-Matti and Kilarski, Laura L. and Holliday, Elizabeth G. and Devan, William J. and Nalls, Mike A. and Wiggins, Kerri L. and Zhao, Wei and Cheng, Yu-Ching and Achterberg, Sefanja and Malik, Rainer and Sudlow, Cathie and Bevan, Steve and Raitoharju, Emma and Oksala, Niku and Thijs, Vincent and Lemmens, Robin and Lindgren, Arne and Slowik, Agnieszka and Maguire, Jane M. and Walters, Matthew and Algra, Ale and Sharma, Pankaj and Attia, John R. and Boncoraglio, Giorgio B. and Rothwell, Peter M. and de Bakker, Paul I. W. and Bis, Joshua C. and Saleheen, Danish and Kittner, Steven J. and Mitchell, Braxton D. and Rosand, Jonathan and Meschia, James F. and Levi, Christopher and Dichgans, Martin and Lehtimäki, Terho and Lewis, Cathryn M. and Markus, Hugh S. (2014) A novel MMP12 locus Is associated with large artery atherosclerotic stroke Using a genome-wide age-at-onset informed approach. PLoS Genetics, 10 (7). pp. e1004469. ISSN: 1553-7390 Opherk, C. and Gonik, M. and Duering, M. and Malik, R. and Jouvent, E. and Herve, D. and Adib-Samii, P. and Bevan, S. and Pianese, L. and Silvestri, S. and Dotti, M. T. and De Stefano, N. and Liem, M. and Boon, E. M. J. and Pescini, F. and Pachai, C. and Bracoud, L. and Muller-Myhsok, B. and Meitinger, T. and Rost, N. and Pantoni, L. and Lesnik Oberstein, S. and Federico, A. and Ragno, M. and Markus, H. S. and Tournier-Lasserve, E. and Rosand, J. and Chabriat, H. and Dichgans, M. (2014) Genome-wide genotyping demonstrates a polygenic risk score associated with white matter hyperintensity volume in CADASIL. Stroke, 45 (4). pp. 968-972. ISSN: 0039-2499