个人简介

Prof Dr Martin Lear is a Senior Lecturer in the School of Chemistry, College of Science, and is an Adjunct Professor of the Global Leader Program at Tohoku University, Science and Engineering. He has spent over 18 years in Asia (mostly in Japan at Tohoku University, with 8 years tenure at the National University of Singapore) and has co-founded a drug-labelling company to combat drug resistance. To date, he has enjoyed mentoring and learning research from 16 PhD, 4 MSc, and 30 BSc students. His current interests lie in developing powerful oxidative and photo-redox methods and applying these methods in both an organic synthesis and MedChem context. Department Responsibilities (Bio)Organic chemistry teaching / research Level-2 programme tutor Exam officer for School of Chemistry Internationalisation activities Subject Specialism Targeting of bioactive small molecules & natural products: new oxidative methods & photoactive tactics Qualifications PhD - Synthesis & Biological Evaluation of Anticancer Agents — The University of Glasgow, 1996 BSc - Honours (Special) in Chemistry with Computer Applications (MedChem) — The University of Glasgow, 1991 Awards Associate College Member of EPSRC — EPSRC Associate Peer Review College, UK, 2016 Fellow of HEA — The Higher Education Academy, UK, 2016 ACP Lectureship Award — Asian Core Program on Cutting Edge Organic Chemistry, 2010 CREST Research Fellow — Ministry of Education, Culture, Sports, Science & Technology, 2000 JSPS Research Fellow — Japanese Society for the Promotion of Science, 1997 Fellow of Wolfson College — The University of Cambridge, 1995 CChem, MRSC — The Royal Society of Chemistry, 1995 PhD Scholarship — The Senate of the University of Glasgow, 1994 Professional Affiliations Global Leader Program of Tohoku University, Science & Engineering — Adjunct Professor

研究领域

Synthesis of First-Generation Elatol Analogues for Bioevaluation — University of Lincoln; started in 2016 Translating Malaria Cell Death into Novel Anti-Malarial Strategies (over 3 years) — Awarded £415,000 by NMRC/IRG11may097 of Singapore; ended in 2015 Fluorescent Tagged Antimalarials as Commercial Molecular Probes to Diagnose Drug Resistance and to Study Diseases (over 1 + 2 years) — Awarded £330,000 by Singapore proof-of-concept (POC) and proof-of-value (POV) company start-up grants; ended in 2014 Lipidomics, novel tools and applications (over 5-years) — Awarded £4,987,000 by NRF-G-CRP 2007-04 of Singapore as part of a consortium; ended in 2013 Synthesis and biology of future anti-malarials derived from bielschowskysin (over 3-years) — Awarded £315,000 by AcRF-MoE Tier-II (T206B1112) of Singapore; ended in 2010 Organic Synthesis - various start-up grants (over 4 years) — Awarded £160,000 by National University of Singapore, Bioimaging Consortium and BMRC of Singapore; ended in 2008 Total synthesis of the kedarcidin chromophore (over 2 years) — Awarded £12,400 by Grant in Aid of Scientific Research, Wakate B, MEXT A of Japan; ended in 2004

Asymmetric halogenation Bioimaging Chemical Libraries Halogen bonding Lead discovery Mode-of-action Natural Products Organic synthesis Oxidative functionalisations Photo-redox methods Photo-smart probes Total synthesis

近期论文

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Li, Jing and Lear, Martin and Hayashi, Yujiro (2016) Sterically demanding oxidative amidation of alpha-substituted malononitriles with amines using O2. Angewandte Chemie International Edition, 55 (31). pp. 9060-9064. ISSN: 1433-7851 Li, Jing and Lear, Martin and Kwon, Eunsang and Hayashi, Yujiro (2016) Mechanism of oxidative amidation of nitroalkanes with oxygen and amine nucleophiles using electrophilic iodine. Chemistry - A European Journal, 22 (16). pp. 5538-5542. ISSN: 0947-6539 Li, Jing and Lear, Martin and Kawamoto, Yuya and Umemiya, Shigenobu and Wong, Alice and Kwon, Eunsang and Hayashi, Yujiro (2015) Oxidative amidation of nitroalkanes with amine nucleophiles using molecular oxygen and iodine. Angewandte Chemie International Edition, 54 (44). pp. 12986-12990. ISSN: 1433-7851 Hayashi, Yujiro and Shomura, Hiroki and Xu, Qianqian and Lear, Martin and Sato, Itaru (2015) Asymmetric aldol reaction of α,α-disubstituted acetaldehydes catalyzed by Ddphenylprolinol silyl ether for the construction of quaternary stereogenic centers. European Journal of Organic Chemistry, 20. pp. 4316-4319. ISSN: 1434-193X Pasari, Sandip and Ismail, Shareef M. and Wenk, Markus R. and Lear, Martin (2015) Preparation of azide biosynthetic surrogates of myo-Inositol. Tetrahedron Letters, 56 (20). pp. 2597-2601. ISSN: 0040-4039 Yamada, Kei and Lear, Martin J. and Yamaguchi, Takaya and Yamashita, Shuji and Gridnev, Ilya D. and Hayashi, Yujiro and Hirama, Masahiro (2014) Biomimetic total synthesis of cyanosporaside aglycons from a single enediyne precursor through site-selective p-benzyne hydrochlorination. Angewandte Chemie International Edition, 53 (50). pp. 13902-13906. ISSN: 1433-7851 Yamada, Kei and Lear, Martin J. and Yamaguchi, Takaya and Yamashita, Shuji and Gridnev, Ilya D. and Hayashi, Yujiro and Hirama, Masahiro (2014) Biomimetic total synthesis of cyanosporaside aglycons from a single enediyne precursor through site-selectivep-benzyne hydrochlorination. Angewandte Chemie International Edition, 53 (50). pp. 13902-13906. ISSN: 1433-7851 Loh, Cheryl C. Y. and Suwanarusk, Rossarin and Lee, Yan Quan and Chan, Kitti W. K. and Choy, Kit-Ying and Rénia, Laurent and Russell, Bruce and Lear, Martin J. and Nosten, François H. and Tan, Kevin S. W. and Chow, Larry M. C. and Snounou, Georges (2014) Characterization of the commercially-available fluorescent chloroquine-BODIPY conjugate, LynxTag-CQGREEN, as a marker for chloroquine resistance and uptake in a 96-well plate assay. PLoS ONE, 9 (10). pp. e110800. ISSN: 1932-6203 Eey, Stanley T.-C. and Lear, Martin J. (2014) Total synthesis of (−)-platensimycin by advancing oxocarbenium- and iminium-mediated catalytic methods. Chemistry - A European Journal, 20 (36). pp. 11556-11573. ISSN: 0947-6539 Brennecke, Johannes and Ochs, Christopher J. and Boudhar, Aïcha and Reux, Bastien and Subramanian, Gomathy Sandhya and Lear, Martin J. and Trau, Dieter and Hobley, Jonathan (2014) Design, preparation and assessment of surface-immobilised tetraphenylethenes for biosensing applications. Applied Surface Science, 307. pp. 475-481. ISSN: 0169-4332 Kotturi, Santosh R. and Somanadhan, Brinda and Ch’ng, Jun-Hong and Tan, Kevin S.-W. and Butler, Mark S. and Lear, Martin J. (2014) Diverted total synthesis of falcitidin acyl tetrapeptides as new antimalarial leads. Tetrahedron Letters, 55 (11). pp. 1949-1951. ISSN: 0040-4039 Lam, S. M. and Tong, L. and Reux, B. and Duan, X. and Petznick, A. and Yong, S. S. and Khee, C. B. S. and Lear, M. J. and Wenk, M. R. and Shui, G. (2014) Lipidomic analysis of human tear fluid reveals structure-specific lipid alterations in dry eye syndrome. The Journal of Lipid Research, 55 (2). pp. 299-306. ISSN: 0022-2275 Lam, Sin Man and Tong, Louis and Reux, Bastien and Lear, Martin J. and Wenk, Markus R. and Shui, Guanghou (2013) Rapid and sensitive profiling of tear wax ester species using high performance liquid chromatography coupled with tandem mass spectrometry. Journal of Chromatography A, 1308. pp. 166-171. ISSN: 0021-9673 Yang, Eugene G. and Sekar, Karthik and Lear, Martin J. (2013) A macrolactonisation approach to the cembrane carbocycle of bielschowskysin. Tetrahedron Letters, 54 (33). pp. 4406-4408. ISSN: 0040-4039 Siebenhofer, Bernhard and Gorelik, Sergey and Lear, Martin J. and Song, Hong Yan and Nowak, Christoph and Hobley, Jonathan (2013) Transient absorption spectroscopy on spiropyran monolayers using nanosecond pump–probe Brewster angle reflectometry. Photochemical & Photobiological Sciences, 12 (5). pp. 848-853. ISSN: 1474-905X Somanadhan, Brinda and Kotturi, Santosh R. and Yan Leong, Chung and Glover, Robert P. and Huang, Yicun and Flotow, Horst and Buss, Antony D. and Lear, Martin J. and Butler, Mark S. (2013) Isolation and synthesis of falcitidin, a novel myxobacterial-derived acyltetrapeptide with activity against the malaria target falcipain-2. The Journal of Antibiotics, 66 (5). pp. 259-264. ISSN: 0021-8820 Ch'ng, Jun-Hong and Mok, Sachel and Bozdech, Zbynek and Lear, Martin James and Boudhar, Aicha and Russell, Bruce and Nosten, Francois and Tan, Kevin Shyong-Wei (2013) A whole cell pathway screen reveals seven novel chemosensitizers to combat chloroquine resistant malaria. Scientific Reports, 3 (1734). ISSN: 2045-2322 Song, Hongyan and Gorelik, Sergey and Hobley, Jonathan and Li, Jiexun and Boudhar, AÏcha and Lear, Martin J. (2013) Pyrene emission from monolayers 'clicked' onto quartz. Journal of Molecular and Engineering Materials, 1 (1). pp. 1250007-1. ISSN: 2251-2373 Yang, Peng-Yu and Wang, Min and Liu, Kai and Ngai, Mun Hong and Sheriff, Omar and Lear, Martin J. and Sze, Siu Kwan and He, Cynthia Y. and Yao, Shao Q. (2012) Parasite-based screening and proteome profiling reveal orlistat, an FDA-approved drug, as a potential anti trypanosoma brucei agent. Chemistry - A European Journal, 18 (27). pp. 8403-8413. ISSN: 0947-6539 Ghosh, Shibaji K. and Butler, Mark S. and Lear, Martin J. (2012) Synthesis of 2-C-methylerythritols and 2-C-methylthreitols via enantiodivergent Sharpless dihydroxylation of trisubstituted olefins. Tetrahedron Letters, 53 (22). pp. 2706-2708. ISSN: 0040-4039 Ghosh, Shibaji K. and Somanadhan, Brinda and Tan, Kevin S.-W. and Butler, Mark S. and Lear, Martin J. (2012) Absolute configuration and total synthesis of a novel antimalarial lipopeptide by the de novo preparation of chiral nonproteinogenic amino acids. Organic Letters, 14 (6). pp. 1560-1563. ISSN: 1523-7060 Yang, Peng-Yu and Liu, Kai and Zhang, Chongjing and Chen, Grace Y. J. and Shen, Yuan and Ngai, Mun Hong and Lear, Martin J. and Yao, Shao Q. (2011) Chemical modification and organelle-specific localization of orlistat-like natural-product-based probes. Chemistry - An Asian Journal, 6 (10). pp. 2762-2775. ISSN: 1861-4728 Eey, Stanley T.-C. and Lear, Martin J. (2010) A bismuth(III)-catalyzed Friedel−Crafts cyclization and stereocontrolled organocatalytic approach to (−)-platensimycin. Organic Letters, 12 (23). pp. 5510-5513. ISSN: 1523-7060 Ngai, Mun H. and Yang, Peng-Yu and Liu, Kai and Shen, Yuan and Wenk, Markus R. and Yao, Shao Q. and Lear, Martin J. (2010) Click-based synthesis and proteomic profiling of lipstatin analogues. Chemical Communications, 46 (44). pp. 8335. ISSN: 1359-7345 Liu, Xiang Hui and Song, Hong Yan and Ma, Xiao Hua and Lear, Martin J. and Chen, Yu Zong (2010) Virtual screening prediction of new potential organocatalysts for direct aldol reactions. Journal of Molecular Catalysis A: Chemical, 319 (1-2). pp. 114-118. ISSN: 1381-1169