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Novel CNS Agonists-Epibatidine Analogues Glycosidase Enzyme Inhibitors Enzyme Mechanisms of Tryptophan Oxidation Mechanistic Free-radical Chemistry

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‘Approaches to syn-7-substituted 2-azanorbornanes as potential nicotinic agonists; Synthesis of syn- and ant-isoepibatidine’ Malpass, JR; Handa S; White R Org. Lett., 2005, 7, 2759-2762. ‘Epibatidine isomers and analogues: Structure-activity relationships’ White R; Malpass JR; Handa S; Baker, SR; Broad, LM; Folly, L; Mogg A Bioorg. & Med. Chem. Lett., 2006, 16, 5493-5497. ‘The Mechanism of Formation of N-Formylkynurenine by Heme Dioxygenases’ Basran J; Efimov, I; Chauhan, N; Thackray, SJ; Krupa, JL; Eaton, G; Griffith, GA; Mowat, CG; Handa, S; Raven EL J. Am. Chem. Soc., 2011, 133 (40), 16251–16257 ‘Evidence for Heme Oxygenase Activity in a Heme Peroxidase’ Badyal, SK; Eaton, G; Mistry, S; Pipirou, Z; Basran J; Metcalfe, CL; Gumiero, A; Handa, S; Moody, PCE; Raven EL ‘Samarium(II)iodide-mediated intramolecular pinacol coupling reactions with cyclopropyl ketones’ Foster SL.; Handa S; Krafft M; Rowling D Chem. Commun. 2007, 4791-4793. ‘Investigations into a free radical-mediated 1,2-imino migration’ Handa, S; Rose, CJ Tetrahedron Lett. 2004, 45, 8643-8645.

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