Yesilkaya , Hasan - University of Leicester - School of Biological Sciences

研究领域

1. Understanding the link between microbial metabolism and virulence. Particular topics, I study include: The pneumococcal mechanisms to acquire host sugars, Regulation of sugar metabolism in Streptococcus pneumoniae. 2. Study of the pathways involved in microbial oxidative stress resistance Characterisation of enzymes that have a role in detoxification of reactive oxygen species, Understanding the regulation of oxidative stress resistance in bacteria.

近期论文

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Paix?o L, Oliveira J, Veríssimo A, Vinga S, Louren?o EC, Ventura MR, Kjos M, Veening JW, Fernandes VE, Andrew PW, Yesilkaya H, Neves AR. Host Glycan Sugar-Specific Pathways in Streptococcus pneumonia: Galactose as a Key Sugar in colonisation and infection. PLoS One. 2015 Mar 31;10(3):e0121042. Gaspar P, Al-Bayati FA, Andrew PW, Neves AR, Yesilkaya H. Lactate dehydrogenase is the key enzyme for pneumococcal pyruvate metabolism and pneumococcal survival in blood. Infect Immun. 2014 Dec;82(12):5099-109. Sandrini S, Alghofaili F, Freestone P, Yesilkaya H . Host stress hormone norepinephrine stimulates pneumococcal growth, biofilm formation and virulence gene expression. BMC Microbiol. 2014 Jul 4;14:180. doi: 10.1186/1471-2180-14-180. PubMed PMID: 24996423; PubMed Central PMCID: PMC4105557. Haste L, Hulland K, Bolton S, Yesilkaya H , McKechnie K, Andrew PW. Development and characterization of a long-term murine model of Streptococcus pneumonia infection of the lower airways. Infect Immun. 2014 Aug;82(8):3289-98. Yesilkaya H , Andisi VF, Andrew PW, Bijlsma JJ. Streptococcus pneumoniae and reactive oxygen species: an unusual approach to living with radicals. Trends Microbiol. 2013 Apr;21(4):187-95. doi: 10.1016/j.tim.2013.01.004. Epub 2013 Feb 13. Review. PubMed PMID: 23415028.