Cooper, Andrea - University of Leicester - School of Biological Sciences

个人简介

Professor Cooper received her undergraduate degree from University College, London and her Doctoral degree from The London School of Hygiene and Tropical Medicine UK, where she investigated the interaction between macrophages and protozoan parasites of the genus Leishmania. Moving to the National Institutes of Health in Bethesda, Maryland, US she expanded her investigation of leishmaniasis to include the T cell response of patients suffering from cutaneous, mucocutaneous and visceral forms of this disease. She then moved to the Mycobacterial Research Labs at Colorado State University and began studying the protective immune response to Mycobacterium tuberculosis. Prior to her move to the University of Leicester she was at the Trudeau Institute, Inc. for 12 years where she held the E.L. Trudeau Chair which allowed her to study the cellular immune response to Mycobacterium tuberculosis.

近期论文

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Torrado E, Fountain JJ, Liao M, Tighe M, Reiley WW, Lai RP, Meintjes G, Pearl JE, Chen X, Zak DE, Thompson EG, Aderem A, Ghilardi N, Solache A, McKinstry KK, Strutt TM, Wilkinson RJ, Swain SL, Cooper AM. 2015 Interleukin 27R regulates CD4+ Tcell phenotype and impacts protective immunity during Mycobacterium tuberculosis infection. Journal of Experimental Medicine. 212(9):1449-63. PMID: 26282876; PubMed Central PMCID: PMC4548054. Okada S, Markle JG, Deenick EK, Mele F, Averbuch D, Lagos M, Alzahrani M, Al-Muhsen S, Halwani R, Ma CS, Wong N, Soudais C, Henderson LA, Marzouqa H, Shamma J, Gonzalez M, Martinez-Barricarte R, Okada C, Avery DT, Latorre D, Deswarte C, Jabot-Hanin F, Torrado E, Fountain J, Belkadi A, Itan Y, Boisson B, Migaud M, Arlehamn CS, Sette A, Breton S, McCluskey J, Rossjohn J, de Villartay JP, Moshous D, Hambleton S, Latour S, Arkwright PD, Picard C, Lantz O, Engelhard,D, Kobayashi M, Abel L, Cooper AM, Notarangelo LD, Boisson-Dupuis S, Puel A, Sallusto F, Bustamante J, Tangye SG, Casanova JL. 2015 Impairment of immunity to Candida and Mycobacterium in humans with bi-allelic RORC mutations. Science. 349(6248):606-13 PubMed PMID: 26160376. Ian M. Orme, Richard T Robinson and Andrea M. Cooper 2015. The balance between protective and pathogenic immune responses in the TB infected lung. Nature Immunology 16:57-63 PMID 25521685 Richard T. Robinson, Ian M. Orme and Andrea M. Cooper 2015. The onset of adaptive immunity in the mouse model of tuberculosis and the factors which compromise its expression. Immunological Reviews, 264:46-59 PMID 25703551 Cruz A, Torrado E, Carmona J, Fraga AG, Costa P, Rodrigues F, Appelberg R, Correia-Neves M, Cooper AM, Saraiva M, Pedrosa J, Castro AG. 2015. BCG vaccination-induced long-lasting control of Mycobacterium tuberculosis correlates with the accumulation of a novel population of CD4(+)IL-17(+)TNF(+)IL-2(+) T cells. Vaccine 33:85-91 PubMed PMID: 25448107. Ray AA, Fountain JJ, Miller HE, Cooper AM, Robinson RT. 2015 IL12Rβ1ΔTM is a secreted product of il12rb1 that promotes control of extra-pulmonary tuberculosis. Infection and Immunity. 83(2):560-71 PubMed PMID: 25404030. PMC4294230 Cooper AM. Mouse model of tuberculosis. Cold Spring Harb Perspect Med. 2014 5:a018556. doi: 10.1101/cshperspect.a018556. PubMed PMID: 25256174. Kai McKinstry, Tara Strutt, Bianca Bautista, Wenliang Zhang, Yi Kuang, Andrea Cooper, and Susan Swain. 2014. Effector CD4 T cell transition to memory requires late cognate interactions that induce autocrine IL-2. Nature Communications 5:5377 PubMed PMID: 25369785; PubMed Central PMCID: PMC4223689. Torrado, E., J. J. Fountain, R. T. Robinson, C. A. Martino, J. E. Pearl, J. Rangel-Moreno, M. Tighe, R. Dunn, and A. M. Cooper. 2013. Differential and site specific impact of B cells in the protective immune response to Mycobacterium tuberculosis in the mouse. PLoS One 8:e61681. Pearl JE, Torrado E, Tighe M, Fountain JJ, Solache A, Strutt T, Swain S, Appelberg R, Cooper AM 2012. Nitric oxide inhibits the accumulation of CD4+ CD44hiTbet+CD69lo T cells in mycobacterial infection. European Journal of Immunology 42:3267-3279 Robinson, RT., S.A. Khader, C.A. Martino, J.J. Fountain, M. Teixeira-Coelho, J.E. Pearl, Stephen T. Smiley, G.M. Winslow, D.L. Woodland, M.J. Walter, J.R. Conejo-Garcia, U. Gubler, A.M. Cooper. 2010 Mycobacterium tuberculosis infection induces il12rb1 splicing to generate a novel IL12Rβ1 isoform that enhances DC migration. Journal of Experimental Medicine 207:591-605 Cruz A, Fraga AG, Fountain JJ, Rangel-Moreno J, Torrado E, Saraiva M, Pereira DR, Randall TD, Pedrosa J, Cooper AM, Castro AG. 2010 Pathological role of interleukin 17 in mice subjected to repeated BCG vaccination after infection with Mycobacterium tuberculosis. Journal of Experimental Medicine 207:1609-1616