Bevington , Alan - University of Leicester - School of Biological Sciences

研究领域

The metabolic basis of the catabolic state that occurs in patients with chronic renal failure, in particular the stimulation of protein catabolism and the impairment of protein synthesis that occurs in skeletal muscle cells in response to uraemic metabolic acidosis. The mechanism whereby low extracellular pH transduces signals into cultured skeletal muscle cells and the involvement of free amino acids and amino acid transport proteins in these signals. The role of the SNAT2 amino acid transporter in the regulation of amino acid signalling, insulin sensitivity and protein metabolism in mammalian cells.

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Watson EL, Kosmadakis GC, Smith AC, Viana JL, Brown JR, Molyneux K, Pawluczyk IZA, Mulheran M, Bishops NC, Shirreffs S, Maughan RJ, Owen PJ, John SG, McIntyre CW, Feehally J, Bevington A. Combined walking exercise and alkali therapy in patients with CKD4-5 regulates intramuscular free amino acid pools and ubiquitin E3 ligase expression. Eur J Appl Physiol 2013 (in press). Doi: 10.1007/s00421-013-2628-5 Kosmadakis GC, John SG, Clapp EL, Viana JL, Smith AC, Bishop NC, Bevington A, Owen PJ, McIntyre CW, Feehally J. Benefits of regular walking exercise in advanced pre-dialysis chronic kidney disease. Nephrol Dial Transplant 2012;27(3):997-1004 Clapp EL, Bevington A, Smith AC. Exercise for children with chronic kidney disease and end-stage renal disease. Pediatr Nephrol 2012;27(2):165-72 Clapp EL, Bevington A. Exercise-induced biochemical modifications in muscle in chronic kidney disease: occult acidosis as a potential factor limiting the anabolic effect of exercise. J Renal Nutr 2011;21(1):57-60 Kosmadakis GC, Bevington A, Smith AC, Clapp EL, Viana JL, Bishop NC, Feehally J. Physical exercise in patients with severe kidney disease. Nephron Clin Pract 2010;115(1):c7-c16