Hollox, Edward J. - University of Leicester - School of Biological Sciences

个人简介

During an undergraduate degree in Natural Sciences, specialising in Biochemistry, a summer research placement developing methods to examine DNA replication origins in Joyce Hamlin’s lab at the University of Virginia sparked Ed’s interest in molecular genetics. Ed moved to the Galton Laboratory at University College London for his PhD in Genetics examining the genetics of lactase persistence in humans under the supervision of Dallas Swallow. After six postdoctoral years in John Armour’s lab at the University of Nottingham, Ed was given the opportunity to start his own lab here in Leicester in 2006.

研究领域

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DNA sequence differences between people are known to be important variables when trying to understand why individuals are different. Most people have two copies of most genes: one inherited from their father, one from their mother. However, for some genes, including many involved in the immune response against infection, individuals have more or fewer than two copies. This is caused by duplication or deletion of genes on some chromosomes carried by those people, and we call this “copy number variation”. Both copy number and DNA sequence variation can exist together – for example a gene which could be present once, twice or three times on a chromosome could have polymorphic sequence differences between each copy. There are several research projects in this area ongoing in the lab, ranging from understanding the evolutionary causes of copy number variation, to its functional consequences and relationship with human disease. A feature of the lab is its collaborations with academics in different institutions around the world. We have long-running active collaborations with colleagues at Karolinska Institute in Stockholm, University of California Davis, University of Tennessee, INSERM Unit in Benin and the Federal University of Minas Gerias in Brazil. Closer to home, Ed has collaborations with Martin Tobin and Louise Wain in the Department of Health Sciences on the genetics of lung function, and with Flav Giorgini here in Genetics.