Higgins, James - University of Leicester - School of Biological Sciences

研究领域

Molecular cell biology of plant sexual reproduction: My aim is to understand how the number and distribution of genetic crossovers are controlled by interacting meiotic proteins in Arabidopsis and crop species, including cereals. This involves analysis of genetic and epigenetic factors that have been selected by evolution to maintain genome integrity.

近期论文

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Wang C, Higgins J, He Y, Lu P, Zhang D, Liang W. (2017) Resolvase OsGEN1 mediates DNA repair by homologous recombination. Plant Physiol. doi: 10.1104/pp.16.01726. (Link) Sepsi A, Higgins JD, Heslop-Harrison JS, Schwarzacher T. (2016) CENH3 morphogenesis reveals dynamic centromere associations during synaptonemal complex formation and the progression through male meiosis in hexaploid wheat. The Plant Journal, doi:10.1111/tpj.13379 (Link) Fu M., Wang C., Xue F., Higgins J., Chen M., Zhang D., and Liang W. (2016) The DNA topoisomerase VI–B Subunit OsMTOPVIB Is Essential for Meiotic Recombination Initiation in Rice. Molecular Plant, 9: 1539-1541. doi: 10.1016/j.molp.2016.07.006 (Link) He Y, Wang C, Higgins JD, Yu J, Zong J, Lu P, Zhang D, Liang W. (2016) MEIOTIC F-BOX Is Essential for Male Meiotic DNA Double Strand Break Repair in Rice. The Plant Cell, 28: 1879-1893. doi:10.1105/tpc.16.00108 (Link) Colas I, Macaulay M, Higgins JD, Phillips D, Barakate A, Posch M, Armstrong SJ, Franklin FC, Halpin C, Waugh R, Ramsay L. (2016) A spontaneous mutation in MutL-Homolog 3 (HvMLH3) affects synapsis and crossover resolution in the barley desynaptic mutant des10. New Phytologist, 212: 693-707. doi:10.1111/nph.14061 (Link) Lambing C, Osman K, Nuntasoontorn K, West A, Higgins JD, Copenhaver GP, Yang J, Armstrong SJ, Mechtler K, Roitinger E, Franklin FCH. (2015) Arabidopsis PCH2 mediates meiotic chromosome remodeling and maturation of crossovers. PLoS Genetics, doi: 10.1371/journal.pgen.1005372 (Link) Bomblies K, Higgins JD, Yant L. (2015) Meiosis evolves: adaptation to internal and external environments. New Phytologist, 208, 306-323. doi: 10.1111/nph.13499 (Link) Higgins JD, Osman K, Jones GH, Franklin FCH. (2014) Factors underlying restricted crossover localization in barley meiosis. Annual Review of Genetics, 48, 29-47 doi: 10.1146/annurev-genet-120213-092509 (Link)TPC cover Barakate A, Higgins JD*, Vivera S, Stephens J, Perry RM, Ramsay L, Colas I, Oakey H, Waugh R, Franklin FCH, Armstrong SJ, Halpin C. (2014) The synaptonemal complex protein ZYP1 is required for imposition of meiotic crossovers in barley. The Plant Cell, 26, 729-740. doi:10.1105/tpc.113.121269 * joint first author (Link) Higgins JD, Wright KM, Bomblies K, Franklin FCH. (2014) Cytological techniques to analyze meiosis in Arabidopsis arenosa for investigating adaptation to polyploidy. Frontiers in Plant Science, 4:546. doi: 10.3389/fpls.2013.00546 (Link)