Foster, Steven - University of Leicester - School of Biological Sciences

个人简介

Steven grew up in South Shields, a seaside town in the north east of England. He completed his B.Sc. (Hons) in Biomedical Sciences in 2002. Following a brief spell working in the biotechnology industry, he undertook a Ph.D. in Genetics under the mentorship of Professor David Lydall (Newcastle University, UK), using budding yeast as a model organism to study the cellular responses to dysfunctional telomeres. He then moved to New York to conduct his postdoctoral training with Dr. John Petrini at the world-renowned Memorial Sloan-Kettering Cancer Center. Expanding his repertoire to include mammalian cell tissue culture and mouse models, he studied chromosome break metabolism and the basic mechanisms of cancer. Steven returned to the UK in 2013 to establish his own research laboratory within the illustrious Department of Genetics at the University of Leicester.

研究领域

Genome Integrity and Cancer

近期论文

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Foster, S.S., De, S., Johnson, L.K., Petrini, J.H. and Stracker, T.H. (2012) Cell cycle- and DNA repair pathway-specific effects of apoptosis on tumor suppression. Proc Natl Acad Sci, 109(25):9953-8. Foster, S.S., Balestrini, A. and Petrini, J.H. (2011) Functional interplay of the Mre11 nuclease and Ku in the response to replication-associated DNA damage. Mol Cell Biol, 31(21):4379-89. Lee, J.H., Choy, M.L., Ngo, L., Foster, S.S. and Marks, P.A. (2010) Histone deacetylase inhibitor induces DNA damage, which normal but not transformed cells can repair. Proc Natl Acad Sci, 17;107(33):14639-44. Usui, T., Foster, S.S. and Petrini, J.H. (2009) Maintenance of the DNA-damage checkpoint requires DNA-damage-induced mediator protein oligomerization. Mol Cell, 33(2):147-59. Zubko, M.K., Maringele, L., Foster, S.S. and Lydall, D. (2006) Detecting repair intermediates in vivo: effects of DNA damage response genes on single-stranded DNA accumulation at uncapped telomeres in budding yeast. Methods Enzymol : DNA Repair Part B, 409:285-300. Foster, S.S., Zubko, M.K., Guillard, S. and Lydall, D. (2006) MRX protects telomeric DNA at uncapped telomeres of budding yeast cdc13-1 mutants. DNA Repair, 13;5(7):840-51.