Badge, Richard - University of Leicester - School of Biological Sciences

个人简介

Richard Badge grew up in the historic port city of Plymouth, United Kingdom. In 1989 he went up to study Pure and Applied Biology at Keble College, Oxford University. He then went on to complete a PhD in the evolutionary population biology and molecular genetics of fruit fly transposable elements at the University of Nottingham. After a postdoctoral period in Nottingham he secured a Wellcome Trust International Travelling Fellowship to work on human transposable elements at the University of Michigan, in Ann Arbor. He completed his Fellowship in the Department of Genetics, University of Leicester in the group of Professor Sir Alec Jeffreys FRS. Now as Lecturer in Bioinformatics in the Department of Genetics he uses computational and molecular genomic methods to study human rodent and primate transposable elements.

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Mu?oz-Lopez M, Macia A, Garcia-Ca?adas M, Badge RM, Garcia-Perez JL. An epi[c] genetic battle: LINE-1 retrotransposons and intragenomic conflict in humans. Mob Genet Elements. 2011 Jul;1(2):122-127. Epub 2011 Jul 1. PubMed PMID:22016860; PubMed Central PMCID: PMC3190314. Macfarlane CM, Collier P, Rahbari R, Beck CR, Wagstaff JF, Igoe S, Moran JV, Badge RM. Transduction-specific ATLAS reveals a cohort of highly active L1 retrotransposons in human populations. Hum Mutat. 2013 Jul;34(7):974-85. doi:10.1002/humu.22327. Epub 2013 Apr 23. PubMed PMID: 23553801; PubMed Central PMCID: PMC3880804. Gray LJ, Leigh T, Davies MJ, Patel N, Stone M, Bonar M, Badge R, Khunti K. Systematic review of the development, implementation and availability of smart-phone applications for assessing type 2 diabetes risk. Diabet Med. 2013 Jun;30(6):758-60. doi: 10.1111/dme.12115. Review. PubMed PMID: 23683104. Beck CR, Garcia-Perez JL, Badge RM, Moran JV. LINE-1 elements in structural variation and disease. Annu Rev Genomics Hum Genet. 2011 Sep 22;12:187-215. Review. PMID: 21801021 Beck CR, Garcia-Perez JL, Badge RM, Moran JV. LINE-1 elements in structural variation and disease. Annu Rev Genomics Hum Genet. 2011 Sep 22;12:187-215. Review. PMID: 21801021 Mu?oz-Lopez M, Macia A, Garcia-Ca?adas M, Badge RM, Garcia-Perez JL. An epi [c] genetic battle: LINE-1 retrotransposons and intragenomic conflict in humans. Mob Genet Elements. 2011 Jul;1(2):122-127. Epub 2011 Jul 1. PMID: 22016860 Freeman P, Macfarlane C, Collier P, Jeffreys AJ, Badge RM. L1 hybridization enrichment: a method for directly accessing de novo L1 insertions in the human germline. Hum Mutat. 2011 Aug;32(8):978-88. doi: 10.1002/humu.21533. Epub 2011 Jul 12. PMID: 21560187 Macia A, Mu?oz-Lopez M, Cortes JL, Hastings RK, Morell S, Lucena-Aguilar G, Marchal JA, Badge RM, Garcia-Perez JL. Epigenetic control of retrotransposon expression in human embryonic stem cells.Mol Cell Biol. 2010 Nov 1. [Epub ahead of print] PMID: 21041477 Ray A, Rahbari R, Badge RM. IAP Display: A Simple Method to Identify Mouse Strain Specific IAP Insertions.Mol Biotechnol. 2010 Sep 26. [Epub ahead of print] PMID: 20872285 Beck CR, Collier P, Macfarlane C, Malig M, Kidd JM, Eichler EE, Badge RM, Moran JV.LINE-1 retrotransposition activity in human genomes. Cell. 2010 Jun 25;141(7):1159-70. PubMed PMID: 20602998. Rahbari R, Sheahan T, Modes V, Collier P, Macfarlane C, Badge RM. A novel L1 retrotransposon marker for HeLa cell line identification. Biotechniques. 2009 Apr;46(4):277-84. PubMed PMID: 19450234; PubMed Central PMCID: PMC2696096. Zemojtel T, Penzkofer T, Schultz J, Dandekar T, Badge R, Vingron M.Exonization of active mouse L1s: a driver of transcriptome evolution? BMCGenomics. 2007 Oct 26;8:392. PubMed PMID: 17963496; PubMed Central PMCID: PMC2176070. Athanikar JN, Badge RM, Moran JV. A YY1-binding site is required for accurate human LINE-1 transcription initiation. Nucleic Acids Res. 2004 Jul 22;32(13):3846-55. Print 2004. PubMed PMID: 15272086; PubMed Central PMCID:PMC506791. Brouha B, Schustak J, Badge RM, Lutz-Prigge S, Farley AH, Moran JV, Kazazian HH Jr. Hot L1s account for the bulk of retrotransposition in the human population. Proc Natl Acad Sci U S A. 2003 Apr 29;100(9):5280-5. Epub 2003 Apr 7. PubMed PMID: 12682288; PubMed Central PMCID: PMC154336. Badge RM, Alisch RS, Moran JV. ATLAS: a system to selectively identifyhuman-specific L1 insertions. Am J Hum Genet. 2003 Apr;72(4):823-38. Epub 2003 Mar 11. PubMed PMID: 12632328; PubMed Central PMCID: PMC1180347. Cheng YC, Lee CJ, Badge RM, Orme AT, Scotting PJ. Sox8 gene expressionidentifies immature glial cells in developing cerebellum and cerebellar tumours. Brain Res Mol Brain Res. 2001 Aug 15;92(1-2):193-200. PubMed PMID: 11483257. Badge RM, Yardley J, Jeffreys AJ, Armour JA. Crossover breakpoint mappingidentifies a subtelomeric hotspot for male meiotic recombination. Hum Mol Genet. 2000 May 1;9(8):1239-44. PubMed PMID: 10767349. Badge RM, Brookfield JF. A novel repressor of P element transposition inDrosophila melanogaster. Genet Res. 1998 Feb;71(1):21-30. PubMed PMID: 9674380. Badge RM, Brookfield JF. The role of host factors in the population dynamics of selfish transposable elements. J Theor Biol. 1997 Jul 21;187(2):261-71. PubMed PMID: 9237896. Brookfield JF, Badge RM. Population genetics models of transposable elements. Genetica. 1997;100(1-3):281-94. PubMed PMID: 9440281.