Twell, David - University of Leicester - School of Biological Sciences

个人简介

David studied Botany at Durham University where he became fascinated with plants, genes and development. He went on to study for a PhD at Rothamsted Experimental Station, Herts and Imperial College London, investigating plant transformation and storage protein genes in potato. He then decided to ‘go west’ as a Post Doctoral Research Geneticist to investigate sexual reproduction and gene regulation in tomato at the Plant Gene Expression Centre in Albany, CA. David returned to the UK in 1990 having been awarded a Royal Society University Research Fellowship to study plant genetics and reproductive biology in the Leicester Biocentre. He subsequently joined the Department of Botany and was awarded a personal Chair at the University in 2000. He then moved to the Department of Biology and joined the Department of Genetics in 2015.

研究领域

Plant reproductive cell biology; Plant developmental biology; Molecular-genetics of plant sexual reproduction; Pollen Development; Genes and proteins regulating asymmetric cell division and germ cell specification; Transcriptional and cell cycle networks in male gametogenesis; Diversity and mechanisms of control by small RNA pathways in male gametophyte development

近期论文

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Borg, M., Brownfield, L., Khatab, H., Sidorova, A., Lingaya, M. and Twell, D. (2011) The R2R3 MYB transcription factor DUO1 activates a male germline-specific regulon essential for sperm cell differentiation in Arabidopsis. Plant Cell 23, 1-16. Brownfield, L., Hafidh, S., Durbarry, A., Khatab, H., Sidorova, A., Doerner, P. and Twell, D. (2009) Arabidopsis DUO POLLEN 3 is a novel regulator of male germline development and embryogenesis. Plant Cell 21, 1940-1956. Brownfield, L., Hafidh, S., Borg, M., Sidorova, A., Mori, T., Twell, D. (2009) A plant germ cell-specific integrator of cell cycle progression and sperm specification. PLOS Genetics 5, e1000430. Kim, H.J., Oh, S-A., Brownfield, L., Ryu, H., Hwang, I., Twell, D.* and Nam, H-G.* (2008) Control of plant male germline proliferation by SCFFBL17 degradation of cell cycle inhibitors. Nature 455, 1134-1137. Oh, S-A., Johnson, J.A., Smertenko, A., Rahman, D., Park, S-K., Hussey, P.J. and Twell, D. (2006) A divergent cellular role for the FUSED kinase family in the plant-specific cytokinetic phragmoplast. Curr. Biol. 15, 2107-2111. Rotman, N., Durbarry, A., Wardle, A., Yang, W-C., Chaboud, A., Faure, J-E., Berger, F and Twell, D. (2005) A novel class of MYB factors controls sperm cell formation in plants. Curr. Biol. 15, 244-248. Honys, D. and Twell, D. (2004) Transcriptome analysis of haploid male gametophyte development in Arabidopsis. Genome Biol. 5:(11)R85. Twell, D., Park, S.K., Hawkins, T.J., Schubert, D., Schmidt, R., Smertenko, A. and Hussey, P.J. (2002) MOR1/GEM1 plays an essential role in the plant-specific cytokinetic phragmoplast. Nat. Cell Biol. 4, 711-714. Eady, C., Lindsey, K. and Twell, D. (1995) The significance of microspore division and division symmetry for vegetative cell-specific transcription and generative cell differentiation. Plant Cell 7, 65-74.