Tobin, Martin - University of Leicester - School of Biological Sciences

研究领域

Investigation of the genetic determinants of common complex diseases and traits, including: precision medicine genome-wide studies of common and rare sequence variation influence of copy number variation lung function and respiratory disease smoking cessation cardiovascular disease and traits, particularly blood pressure genomics in drug discovery, drug repositioning and stratified medicine development and utilisation of new methods for the above studies.

近期论文

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Ehret GB, Ferreira T, ...[many authors]...Tobin MD, ...[many authors]...Morris AP, Newton-Cheh C, Munroe PB. The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals. Nat Genet. 2016 Sep 12. PMID: 27618452. Surendran P, Drenos F…[many authors]…Tobin MD, Nordestgaard BG; T2D-GENES Consortium; GoT2DGenes Consortium; ExomeBP Consortium; CHD Exome+ Consortium, Caulfield MJ, Mahajan A, Morris AP, Tomaszewski M, Samani NJ, Saleheen D, Asselbergs FW, Lindgren CM, Danesh J, Wain LV, Butterworth AS, Howson JM, Munroe PB. Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension. Nat Genet. 2016 Sep 12. PMID: 27618447. Kanoni S, Masca NG, [many authors], Tobin MD, Jarvelin MR, Zeggini E, Gieger C, Chambers JC, Wareham NJ, Munroe PB, Franks PW, Samani NJ, Deloukas P. Analysis with the exome array identifies multiple new independent variants in lipid loci. Hum Mol Genet. 2016 Jul 27. pii: ddw227. PMID: 27466198. O'Connell J, Sharp K, Shrine N, Wain L, Hall I, Tobin M, Zagury JF, Delaneau O, Marchini J. Haplotype estimation for biobank-scale data sets. Nat Genet. 2016 Jun 6. PubMed PMID: 27270105. Jackson VE, Ntalla I, Sayers I, …[many authors]… Strachan DP, Hall IP, Tobin MD, Wain LV. Exome-wide analysis of rare coding variation identifies novel associations with COPD and airflow limitation in MOCS3, IFIT3 and SERPINA12. Thorax. 2016 Jun;71(6):501-9. PMID: 26917578 Parmar PG, [25 authors], Tobin MD [9 authors], Palmer LJ. International GWAS Consortium Identifies Novel Loci Associated with Blood Pressure in Children and Adolescents. Circ Cardiovasc Genet, 2016, March 11. PMID 26969751. Soler Artigas M, Wain LV, …Strachan DP, Hall IP, Tobin MD. Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation. Nat Commun. 2015 Dec 4;6:8658. PMID: 26635082; PMCID: PMC4686825. Wain LV, Shrine N, Miller S…Strachan DP, Tobin MD, Hall IP. Novel insights into the genetics of smoking behaviour, lung function, and chronic obstructive pulmonary disease (UK BiLEVE): a genetic association study in UK Biobank. Lancet Respir Med. 2015 Oct;3(10):769-81. PMID: 26423011; PMCID: PMC4593935. Obeidat M, Hao K, Bossé Y…Sin DD, Tobin MD, London SJ, Hall IP, Paré PD. Molecular mechanisms underlying variations in lung function: a systems genetics analysis. Lancet Respir Med. 2015 Oct;3(10):782-95. PMID: 26404118. Gharib SA, Loth DW, Soler Artigas M…Tobin MD, London SJ. Integrative pathway genomics of lung function and airflow obstruction. Hum Mol Genet. 2015 Dec 1;24(23):6836-48. PMID: 26395457; PMCID: PMC4643644. UK10K Consortium. The UK10K project identifies rare variants in health and disease. Nature. 2015 Oct 1;526(7571):82-90. PMID:26367797; PMCID: PMC4773891. Horikoshi M, M?gi R, ..[many authors]…Tobin MD, …..[many authors]…McCarthy MI, Morris AP; ENGAGE Consortium. Discovery and Fine-Mapping of Glycaemic and Obesity-Related Trait Loci Using High-Density Imputation. PLoS Genet. 2015 Jul 1;11(7):e1005230. PMID: 26132169; PMCID: PMC4488845. H?gg S, Fall T, ..[many authors]… Tobin MD..[many authors]…Pedersen NL, Ingelsson E. Adiposity as a cause of cardiovascular disease: a Mendelian randomization study. Int J Epidemiol. 2015 Apr;44(2):578-86. PMID: 26016847; PMCID: PMC4553708. Surakka I, Horikoshi M, ..[many authors]…Tobin MD..[many authors]…Prokopenko I, Ripatti S; ENGAGE Consortium. The impact of low-frequency and rare variants on lipid levels. Nat Genet. 2015 Jun;47(6):589-97. PMID: 25961943; PMCID: PMC4757735. Loth DW, Artigas MS, Gharib SA, Wain LV, Franceschini N, Koch B, ... Cassano PA, Sood A, Hayward C, Dupuis J, Hall IP, Brusselle GG, Tobin MD, London SJ. Genome-wide association analysis identifies six new loci associated with forced vital capacity. Nat Genet. 2014 Jun 15. PubMed PMID: 24929828. Wain LV, Sayers I, Soler Artigas M, Portelli MA, Zeggini E, Obeidat M, Sin DD,...Shrine NR, Cook JP, Patel S, Spector TD, Hollox EJ, Hall IP, Tobin MD. Whole exome re-sequencing implicates CCDC38 and cilia structure and function in resistance to smoking related airflow obstruction. PLoS Genet. 2014 PubMed PMID: 24786987. Wain LV, Odenthal-Hesse L, Abujaber R, Sayers I, Beardsmore C, Gaillard EA, Kuehni CE, Hall IP, Tobin MD, Hollox EJ. Copy number variation of the Beta-defensin genes in europeans: no supporting evidence for association with lung function, chronic obstructive pulmonary disease or asthma. PLoS One. 2014 Jan 3;9(1):e84192. PubMed PMID: 24404154.