Oggioni, Marco - University of Leicester - School of Biological Sciences

个人简介

Marco Rinaldo Oggioni went to Medical School at the University of Siena (Italy) and later at the University of Verona (Italy) where he obtained his medical degree (1990). During these years he spent a period as guest investigator at the Rockefeller University, New York (USA). Back at the University of Siena he obtained a specialisation degree Microbiology and Virology (1994). His research work started in Siena with Prof. Gianni Pozzi on biotechnological projects aimed at using non-pathogenic streptococci as life vaccine vectors. From 1993 to 2013 he was employed at the University Hospital of Siena and had a series of teaching contracts at the University of Siena, including the course of Molecular Microbiology in the Master´s Programme in Medical Biotechnology taught in English. His two distinct research groups at the hospital and the university focussed respectively on innovative molecular diagnostics and molecular mechanisms of drug resistance and on the other hand on the molecular pathogenesis and genomics of the human pathogen Streptococcus pneumoniae. In 2013 he joined the Department of Genetics of the University of Leicester where he was awarded with a Chair position in Microbial Genetics

研究领域

I have two main areas of interest. Analysis of virulence mechanisms of Streptococcus pneumoniae, by use of genomic tools, study of microbial physiology, set up of novel in vitro models including biofilms and in vivo infection models. Main scope is the recognition of specific phases characterising microbial physiology during infection with the aim of identification of novel drug targets. In this context I have focused my attention on carbon metabolism of the bacterium, both in vitro and within the host, with the idea that the “behavior” of the bacterium is largely influenced by their metabolism and that nutrient availability in different niches within the host govern important aspects in host pathogen interaction. Interaction with engineers and mathematicians expert in complex models has added interdisciplinary aspects to my research. Development and validation of innovative tools and protocols for molecular diagnostics of microbial infections including molecular drug susceptibility testing. I have been involved for years in design of primer probe based diagnostic approaches, based initially on PCR and later on arrays and real time PCR. Part of this work included involvement in characterisation of molecular mechanisms of drug resistance, including work on mutations in mycobacteria, target substitutions in staphylococci, efflux pumps in pneumococci and staphylococci and the characterization of mobile elements more in general. Most recently I have investigated biocide resistance mechanism in staphylococci and microbial species of interest for the food chain, with the aim to elucidate possible impact of biocide use on antimicrobial drug resistance.

近期论文

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Sánchez MB, F Decorosi, C Viti, MR. Oggioni, JL. Martínez, A Hernández. 2015. Predictive studies suggest that the risk for the selection of antibiotic resistance by biocides is likely low in Stenotrophomonas maltophilia. PLoS One.10(7):e0132816. Grandgirard D, L Furi, ML Ciusa , L Baldassarri, Daniel R. Knight , Ian Morrissey, CR. Largiader, SL. Leib, MR. Oggioni. 2015. Mutations upstream of fabI in triclosan resistant Staphylococcus aureus strains are associated with elevated fabI gene expression. BMC Genomics 16(1):345 doi 10.1186/s12864-015-1544-y. Trappetti C. and M.R. Oggioni. 2015. Biofilm formation under in vitro conditions. In: Streptococcus pneumoniae; Molecular mechanisms of host-pathogen interaction. Brown J., S. Hammerschmidt and C. Orihuela Eds., Academic Press, London. ISBN: 978-0-12-410530-0. p. 246-254. Curiao T, E Marchi, C Viti, MR Oggioni, F Baquero, J-L Martínez, T Coque. 2015. Polymorphic variation in sensitivity and metabolism of triclosan-resistant mutants of Escherichia coli and Klebsiella pneumoniae clinical strains obtained after exposure to biocides and antibiotics. Antimicrobial Agents and Chemotherapy. 59(6):3413-23. Oggioni MR, JR Coelho, L Furi, DR Knight, C Viti, G Orefici, J-L Martinez, AT Freitas, TM Coque, I Morrissey, on behalf of the Biohypo Consortium. 2015. Significant differences characterise the correlation coefficients between biocide and antibiotic susceptibility profiles in Staphylococcus aureus. Current Pharmaceutical Design, 21(16):2054-7. Marchi E, Furi L, Arioli S, Morrissey I, Di Lorenzo V, Mora D, Giovannetti L, Oggioni MR, Viti C. 2015. Novel insight into antimicrobial resistance and sensitivity phenotypes associated to qac and norA genotypes in Staphylococcus aureus. Microbiological Research. 170:184-194. Wright EA, V Di Lorenzo, C Trappetti, M Liciardi, G Orru, C Viti, C Bronowski, AJ Hall, AC Darby, MR Oggioni and C Winstanley, 2015. Divergence of a strain of Pseudomonas aeruginosa during an outbreak of ovine mastitis. Veterinary Microbiology, 175(1):105-13. Yavuz M, MR Oggioni, U Yetis and FB. Dilek. 2015. Biocides in drinking water system of Ankara, Turkey. Desalination and Water Treatment. 53:3253-3262. Ricci S, Grandgirard D, Wenzel M, Braccini T, Salvatore P, Oggioni MR, Leib SL, Koedel U. 2014. Inhibition of matrix metalloproteinases attenuates brain damage in experimental meningococcal meningitis. BMC Infect Dis., 14(1):3853. Iannelli F, M Santagati, F Santoro, MR Oggioni, S Stefani and G Pozzi. 2014. Nucleotide sequence of conjugative prophage Phi1207.3 (formerly Tn1207.3) carrying the mef(A)/msr(D) genes for efflux resistance to macrolides in Streptococcus pyogenes. Frontiers in Microbiology 5:687. Manso AS, MH Chai, JM Atack, L Furi, M De Ste Croix, R Haigh, C Trappetti, AD Ogunniyi, LK Shewell, M Boitano, TA Clark, J Korlach, M Blades, E Mirkes, AN Gorban, JC Paton, MP Jennings, MR Oggioni. 2014. A random six-phase switch regulates pneumococcal virulence via global epigenetic changes. Nature Commun. 5:5055 doi: 10.1038/ncomms6055 Rukke HV, Kalluru RS, Repnink U, Gerlini A, José RJ, Periselneris J, Marshall H, Griffiths G, Oggioni MR, Brown JS, Petersen FC. 2014. Protective role of the capsule and impact of serotype 4 capsule switching on Streptococcus mitis. Infect Immun. 82(9):3790-801. Gerlini A, L Colomba, L Furi, T Braccini, AS Manso, A Pammolli, B Wang, A Vivi, M Tassini, N van Rooijen, G Pozzi, S Ricci, PW Andrew, U Koedel, ER Moxon and MR Oggioni. 2014. The role of host and microbial factors in the pathogenesis of pneumococcal bacteraemia arising from a single bacterial cell bottleneck. PLoS Pathogens 10(3): e1004026. Morrissey I, MR Oggioni, D Knight, T Curiao,T Coque, A Kalkanci , JL Martinez and the BIOHYPO Consortium. 2014. Evaluation of epidemiological cut-off values indicates that biocide resistant subpopulations are uncommon in natural isolates of clinically-relevant microorganisms. PLoS ONE, 9(1):e86669. Iannelli F, F Santoro, MR Oggioni, and Gianni Pozzi. 2014. Nucleotide Sequence Analysis of Integrative Conjugative Element Tn5253 of Streptococcus pneumoniae. Antimicrob. Agents. Chemother. 58(2):1235-9. Koc A, KB Orhon, A Ogutverici, L Furi, MR Oggioni, FB Dilek, and U Yetis. 2014. Is Adsorption an artefact in experimentation with triclosan? Desalination and Water Treatment, 52:7101-7107. Merker M, Kohl TA, Roetzer A, Truebe L, Richter E, Rüsch-Gerdes S, Fattorini L, Oggioni MR, Cox H, Varaine F, Niemann S. 2013. Whole Genome Sequencing Reveals Complex Evolution Patterns of Multidrug-Resistant Mycobacterium tuberculosis Beijing Strains in Patients. PLoS One. 2013;8(12):e82551. Farhat MR, Shapiro BJ, Kieser KJ, Sultana R, Jacobson K, Victor TC, Warren RW, Streicher EM, Calver A, Sloutsky A, Kau D, Posey JE, Plikaytis B, Oggioni MR, Gardy JL, Johnston JC, Rodrigues M, Tang PKC, Kato-Maeda M, Kreiswirth B, Kurepina N, Borowski M, Muddukrishan B, Galagan J, Gagneux S, Birren B, Rubin EJ, Lander ES, Sabeti P, Murray M. 2013. Convergent Evolution Reveals Targets of Positive Selection in Drug Resistant Mycobacterium tuberculosis Strains. Nature Genetics. 45(10):1183-1189. Ricci S, Gerlini A, Pammolli A, Chiavolini D, Braione V, Tripodi SA, Colombari B, Blasi E, Oggioni MR, Peppoloni S, Pozzi G. 2013 Contribution of different pneumococcal virulence factors to experimental meningitis in mice. BMC Infect Dis. 13(1):444. Furi L, ML Ciusa, D Knight, V Di Lorenzo, N Tocci, D Cirasola, L Aragones, JR Coelho, AT Freitas, E Marchi, L Moce, P Visa, J Blackman Northwood, C Viti, E Borghi, G Orefici, the BIOHYPO consortium, I Morrissey, and MR Oggioni. 2013. Evaluation of reduced susceptibility to quaternary ammonium compounds and bisbiguanides in clinical isolates and laboratory-generated mutants of Staphylococcus aureus. Antimicrob. Agents. Chemother. 57(8):3488-97. Maillard J-Y, S Bloomfield, JR Coelho, P Collier, B Cookson, S Fanning, A Hill, P Hartemann, A McBain, MR Oggioni, S Sattar, HP Schweizer, J Threlfall. 2013. Does microbicide use in consumer products promote antimicrobial resistance? A critical review and recommendations for a cohesive approach to risk assessment. Microb. Drug Res., 19(5):344-54. doi: 10.1089/mdr.2013.0039. Oggioni MR, L. Furi, JR Coelho, JY Maillard, JL Martinez. 2013. Recent advances in the potential interconnection between antimicrobial resistance to biocides and antibiotics. Expert Review of Anti-infective Therapy. 11(4):363-6. doi: 10.1586/eri.13.16. Coelho JR, JA Carri?o, D Knight, J-L Martínez, I Morrissey, MR Oggioni, and AT Freitas. 2013. The use of machine learning methodologies to analyse antibiotic and biocide susceptibility in Staphylococcus aureus. PLoS One. 2013;8(2):e55582. doi: 10.1371/journal.pone.0055582. Tocci N, F Iannelli, A Bidossi, ML Ciusa, F Decorosi, C Viti, G Pozzi, S Ricci, MR Oggioni. 2013. Functional analysis of pneumococcal drug efflux pumps associates the MATE DinF transporter to quinolone susceptibility. Antimicrobial Agents Chemotherapy, 57(1):248–253. doi: 10.1128/AAC.01298-12. Kaur Hayre J, G Xu, L Borgianni, GL Taylor, PW Andrew, JD Docquier, MR Oggioni. 2012. Optimization of a direct spectrophotometric method to investigate the kinetics and inhibition of sialidases. BMC Biochemistry, 13(1):19. doi:10.1186/1471-2091-13-19.