Kyriacou, Charalambos P. - University of Leicester

个人简介

Bambos was born in Camden and spent his school years in North London. During the week he helped out in his father’s restaurant in Finchley, and during the summers he worked in the local graveyard. He went to Birmingham at 17 and read Psychology, where one of his lecturers turned his attention towards behavioural genetics. His PhD in this subject using Drosophila was carried out jointly in the Departments of Psychology and Genetics in Sheffield. After spending one year in Psychology at the University of Edinburgh as a Demonstrator, he moved to Brandeis University in Boston, where he worked with Jeff Hall on the neurogenetics of sexual and circadian behaviour in flies. He continued this collaboration into the 1980’s and 1990’s, and was involved in the pioneering molecular analyses of fly circadian rhythm genes, first in Edinburgh, then in the Genetics department at Leicester, where he has worked since 1984. He was promoted to Reader in 1992 and a Personal Chair in 1996. He was elected to the Academy of Medical Sciences in 2000 and was HoD in 2000-2001.

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Tauber, E., Zordan, M. A., Sandrelli, .F, Pegoraro, M., Daga, A., Osterwalder, N., Selmin, A., Etournay, R., Monger, K., Rosato, E., Kyriacou C. P.* & Costa, R. 2007. Natural selection favours a newly derived timeless allele in Drosophila melanogaster. Science, 316, 1895-98 Sandrelli, F., Tauber, E., Pegoraro, M., Mazzotta, G., Cisotto, G., Piccin, A., Rosato, E., Zordan, M., Costa, R. & Kyriacou, C.P, 2007. Molecular basis for natural selection at the timeless locus in Drosophila melanogaster. Science, 316, 1898-900. Codd, V., Dolezel, D., Piccin, A., Garner, K.J., Racey, S.N., Straatman, K.R., Louis, E.J, Costa, R., Sauman, I., Kyriacou, C.P.* & Rosato, E. 2007 Circadian rhythm gene regulation in the housefly, Musca domestica. Genetics, 177, 1539-51 Moran, C.N. & Kyriacou, C.P. 2009. Functional neurogenomics of the courtship song of male Drosophila melanogaster. Cortex, 45, 18-34 Maywood E.S., Chahad-Ehlers S., Garabette M.L., Pritchard C., Underhill P., Greenfield A., Ebling F.J.P., Kyriacou C.P., Hastings M.H. & Reddy A.B. 2009. Differential testicular gene expression in seasonal fertility. J biol Rhythms 24, 114-125 Last, K.S., Bailhache, T., Kramer, C., Kyriacou, C.P., Rosato, E., & Olive, P.J.W. 2009. Tidal, daily, and lunar-day biorhythmicity in the marine polychaete Nereis virens. Chronobiol Int. 26, 167-183 Deery M., Maywood E.S., Chesham J.C., Sladek M., Karp N.A., Green E. W., Charles P.D., Reddy A.B., Kyriacou C.P., Lilley K.S., Hastings M.H. 2009 Proteomic analysis reveals the role of synaptic vesicle cycling in sustaining the suprachiasmatic circadian clock. Curr Biol 19, 2031-6 Ben-Shlomo R., & Kyriacou, C P. 2010 Light pulses administered during the circadian dark phase alter expression of cell cycle associated transcripts in mouse brain. Cancer Genetics and Cytogenetics. 197, 65-70 Benna, C., Bonaccorsi, S., Wülbeck, C., Helfrich-F?rster, C., Gatti, M., Kyriacou, C.P. Costa, R. & Sandrelli, F. 2010 Drosophila timeless 2 is required for chromosome stability and circadian photoreception. Curr Biol 20, 346-352 Richards, P., Didszun, C., Campesan, S., Simpson, A., Horley, B., Young, K. W., Glynn, P., Cain, K., Kyriacou, C. P., Giorgini, F., & Nicotera, P. 2011 Huntingtin aggregates cause loss of dendritic spines by disrupting endosomal recycling. Cell Death & Differentiation. Wilcockson D.C., Zhang L., Hastings M.H. Kyriacou, C. P., & Webster, S.G. 2011 A novel form of pigment-dispersing hormone in the intertidal marine isopod, Eurydice pulchra (Leach). J Comp Neurol Campesan S, Green EW, Breda C, Sathyasaikumar KV, Muchowski PJ, Schwarcz R Kyriacou CP & Giorgini F. 2011 The Kynurenine Pathway Modulates Neurodegeneration in a Drosophila Model of Huntington’s Disease. Curr Biol 21, 961-6. Vanin S, Bhutani S, Montelli, S, Menegazzi P, Green EW, Pegoraro M, Sandrelli F, Costa R & Kyriacou CP. 2012 Unexpected features of Drosophila circadian behavioural rhythms under natural conditions. Nature 484, 371-6 Green EW, Campesan S, Breda C, Sathyasaikumar KV, Muchowski PJ, Schwarcz R, Kyriacou CP, Giorgini F. 2012 Drosophila eye color mutants as therapeutic tools for Huntington’s disease. Fly 6, 117-20 Steinert JR, Campesan S, Richards P, Kyriacou CP, Forsythe ID, Giorgini F. 2012 Rab11 modulates synaptic dysfunction and behavioural deficits in a Drosophila model of Huntington’s disease. Human Mol Gen 21, 2912-22 Edgar RS, Green EW, Zhao Y, van Ooijen G, Olmedo M, Qin X, Xu Y, Pan M, Valekunja UK, Feeney KA, Maywood ES, Hastings MH, Baliga NS, Merrow M, Millar AJ, Johnson CH, Kyriacou CP, O’Neill JS, Reddy AB. 2012 Peroxiredoxins are conserved markers of circadian rhythms. Nature, 485, 459-64 Allebrandt KV, Amin N, Müller-Myhsok B, Esko T, Teder-Laving M, Azevedo RV, Hayward C, van Mill J, Vogelzangs N, Green EW, Melville SA, Lichtner P, Wichmann HE, Oostra BA, Janssens AC, Campbell H, Wilson JF, Hicks AA, Pramstaller PP, Dogas Z, Rudan I, Merrow M, Penninx B, Kyriacou CP, Metspalu A, van Duijn CM, Meitinger T, Roenneberg T. 2013 A K(ATP) channel gene effect on sleep duration: from genome-wide association studies to function in Drosophila. Mol Psychiatry. 18, 122–132. Menegazzi P, Vanin S, Yoshii T, Rieger D, Hermann C, Dusik V, Kyriacou CP, Helfrich-F?rster C, Costa R. 2013 Drosophila clock neurons under natural conditions. J Biol Rhythms, 28, 3-14 Mason, RP, Casu, M, Butler, N, Breda, C, Campesan S, Clapp, J, Green, EW, Kyriacou, CP & Giorgini, F. 2013 Glutathione peroxidase activity is neuroprotective in models of Huntington’s disease. Nat Genet, 45, 1249-54 Zhang, L., Hastings M.H., Green E.W., Tauber E., Sladek, M., Webster S. G*., Kyriacou C.P*. and Wilcockson D.C. 2013 Dissociation of circadian and circatidal rhythms in a marine crustacean, Eurydice pulchra. Curr Biol, 23, 1863-73. Green, E.W., Fedele, G., Giorgini, F., & Kyriacou C.P. 2014 Widely used Drosophila RNAi collection is subject to dominant, off-target phenotypic effects Nature Methods, 11, 222-3 Kyriacou CP, Green EW, Piffer A, Dowse HB 2017 Failure to reproduce period-dependent song cycles in Drosophila is due to poor automated pulse-detection and low intensity courtship. Proc Natl Acad Sci USA In Press [ Raw data click here]