Giorgini, Flaviano - University of Leicester - School of Biological Sciences

个人简介

Flaviano Giorgini grew up amidst the corn fields of Indiana and pursued a BSc degree in Biological Sciences (with an emphasis in Genetics) at Purdue University. He obtained a MA degree in Molecular Genetics at Washington University in Saint Louis and a PhD in Genetics at the University of Washington in Seattle. His interest in neurodegeneration research began as a Senior Fellow in the Department of Pharmacology (University of Washington). His work during this time, combined with his background in genetics and model organisms, formed the basis for his current research in neurogenetics at the University of Leicester. He started as a Lecturer in the Department of Genetics in 2006, was promoted to Reader in Neurogenetics in 2012, as has been Professor of Neurogenetics since 2015.

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Breda C, Giorgini F, Steinert, JR. Synapses and α-synuclein signalling in disease. Cogent Biology, in press.Maddison DC, Giorgini F*. The kynurenine pathway and neurodegenerative disease. Sem Cell Dev Biol, 2015 Apr;40:134-141. Varadarajan S, Breda C, Smalley JL, Butterworth M, Farrow S, Giorgini F, Cohen G. The transrepression arm of glucocorticoid receptor signalling is protective in mutant huntingtin-mediated neurodegeneration. Cell Death Differ, 2015 Aug;22(8):1388-96. Breda C, Nugent ML, Estranero JG, Kyriacou CP, Outeiro TF, Steinert JR, Giorgini F*. Rab11 modulates α-synuclein mediated defects in synaptic transmission and behaviour. Hum Mol Genet 2015; 24(4):1077-91. Mason RP, Breda C, Kooner GS, Mallucci GR, Kyriacou CP, Giorgini F*. Modelling Huntington’s disease in yeast and invertebrates. Movement Disorders: Genetics and Models, Second Edition(Elsevier), 2015: 557 - 572. Chutna O, Gon?alves S, Villar-Piqué A, Guerreiro P, Marijanovic Z, Mendes T, Ramalho J, Emmanouilidou E, Ventura S, Klucken J, Barral DC, Giorgini F, Vekrellis K, Outeiro TF. The small GTPase Rab11 co-localizes with α-synuclein in intracellular inclusions and modulates its aggregation, secretion and toxicity. Hum Mol Genet, 2014; 23(25): 6732-45. Zondler L, Miller-Fleming L, Repici M, Gon?alves S, Tenreiro S, Rosado-Ramos R, Betzer C, Straatman KR, Henning Jensen P, Giorgini F*, Outeiro TF*. DJ-1 interactions with α-synuclein attenuate aggregation and cellular toxicity in models of Parkinson’s disease. Cell Death Dis, 2014; 5: e1350. Yin G, Lopes da Fonseca T, Eisbach SE, Martín Anduaga A, Breda C, Karpinar DP, Orcellet ML, Szeg? EM, Guerreiro P, Lazaro D, Braus GH , Fernandez CO, Griesinger C, Becker S, Goody RS, Itzen A, Giorgini F, Outeiro TF, Zweckstetter M. alpha-Synuclein interacts with the switch region of Rab8a in a Ser129 phosphorylation-dependent manner. Neurobiology of Disease, 2014; 70:149-61. Kantcheva RB, Mason RP*, Giorgini F*. Aggregation-Prone Proteins Modulate Huntingtin Inclusion Body Formation in Yeast. PLoS Currents, 2014 Apr 23;6. Miller-Fleming L, Antas P, Faria Pais T, Smalley JL, Giorgini F*, Outeiro TF*. Yeast DJ-1 family members are required for diauxic-shift reprogramming and cell survival in stationary phase. PNAS, 2014; 111(19): 7012-7. Green EW, Fedele G, Giorgini F, Kyriacou CP. Widely used Drosophila RNAi collection is subject to dominant, off-target phenotypic effects. Nat Methods, 2014; 11(3):222-3. Vittori A, Breda C, Repici M, Orth M, Roos RAC, Outeiro TF, Giorgini F, Hollox EJ and the REGISTRY investigators of the European Huntington’s Disease Network. Copy number variation of the neuronal glucose transporter gene SLC2A3 modifies the age of onset in Huntington’s disease. Hum Mol Genet, 2014 Feb 5. [Epub ahead of print]. Sajjad MU, Green EW, Miller-Fleming L, Hands S, Herrera F, Campesan S, Khoshnan A, Outeiro TF, Giorgini F, Wyttenbach A. DJ-1 modulates aggregation and pathogenesis in models of Huntington’s disease. Hum Mol Genet, 2014; 23 (3): 755-766. Giorgini F, Huang SY, Sathyasaikumar KV, Notarangelo FM, Thomas MAR, Tararina M, Wu HQ, Schwarcz R, Muchowski PJ. Targeted Deletion of Kynurenine 3-monooxygenase (KMO) in Mice: a New Tool for Studying Kynurenine Pathway Metabolism in Periphery and Brain. J Biol Chem, 2013; 288: 36554-36566. Giorgini F and Steinert J. Rab11 as a modulator of synaptic transmission. Commun Integr Biol, 2013; 6(6): e26807. Woodacre A, Lone MA, Jablonowski D, Schneiter R, Giorgini F*, Schaffrath R*. A novel Sit4 phosphatase complex is involved in the response to ceramide stress in yeast. Oxid Med Cell Longev, 2013, Article ID 129645. Mason RP, Casu M, Butler N, Breda C, Campesan S, Clapp J, Green EW, Dhulkhed D, Kyriacou CP, Giorgini F*. Glutathione peroxidase activity is neuroprotective in models of Huntington's disease. Nat Genet, 2013; 45(10): 1249-54. Giorgini F*. A flexible polyglutamine hinge opens new doors for understanding huntingtin function. PNAS, 2013; 110(36): 14516-7. Giorgini F*. Understanding neuronal dysfunction and loss in neurodegenerative disease. J Mol Med (Berl), 2013; 91(6): 651-2. Amaral M, Outeiro TF, Scrutton NS, Giorgini F*. The causative role and therapeutic potential of the kynurenine pathway in neurodegenerative disease. J Mol Med (Berl), 2013; 91(6): 705-13. Amaral M, Levy C, Heyes DJ, Lafite P, Outeiro TF, Giorgini F, Leys D, Scrutton NS. Structural basis of kynurenine 3-monooxygenase inhibition. Nature, 2013; 496(7445): 382-5. Uthman S, B?r C, Scheidt V, Liu S, ten Have S, Giorgini F, Stark MJ, Schaffrath R. The amidation step of diphthamide biosynthesis in yeast requires DPH6, a gene identified through mining the DPH1-DPH5 interaction network. PLoS Genet, 2013; 9(2): e1003334. Repici M, Straatman KR, Balduccio N, Enguita FJ, Outeiro TF, Giorgini F*. Parkinson's disease-associated mutations in DJ-1 modulate its dimerization in living cells. J Mol Med (Berl), 2013; 91(5): 599-611. Kwan W, Traeger U, Davalos D, Chou A, Andre R, Miller A, Giorgini F, Cheah C, Moeller T, Stella N, Akassoglou K, Tabrizi S, Muchowski, P. J. Mutant huntingtin impairs the migration of immune cells in Huntington's disease. J Clin Invest, 2012; 122(12): 4737-47. Green EW and Giorgini F*. Choosing and Using Drosophila Models to Characterise Modifiers of Huntington’s Disease. Biochem Soc Trans, 2012; 40(4): 739-45. Green, EW, Campesan, S, Breda, C, Sathyasaikumar, KV, Muchowski, PJ, Schwarcz, R, Kyriacou, CP, Giorgini, F*. Drosophila eye color mutants as therapeutic tools for Huntington’s disease. Fly 2012; 6(2).