Dubrova, Yuri E. - University of Leicester - School of Biological Sciences

个人简介

Yuri Dubrova grew up in Kiev, Ukraine. He did his undergraduate degree in Biology at Kiev State University (Ukraine), and PhD and DrSci in Genetics at NI Vavilov Institute of General Genetics, Moscow. In 1994 he moved to Leicester.

研究领域

Professor Yuri Dubrova’s research interests focus on the analysis of germline mutation induction in humans and mice following exposure to ionising radiation, chemical mutagens and some anticancer drugs.

近期论文

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Sarapultseva EI, Igolkina JV, Tikhonov VN, Dubrova YE. 2014. The in vivo effects of low-intensity radiofrequency fields on the motor activity of protozoa. Intl. J. Radiat. Biol. 90, 262-267. PMID: 24266430 Dubrova YE. 2013. The transgenerational effects of parental exposure to mutagens in mammals. In: Stress-Induced Mutagenesis. D Mittelman ed. Springer, NY, pp. 243-255. Abouzeid Ali HE, Barber RC, Dubrova YE. 2012. The effects of maternal irradiation during adulthood on mutation induction and transgenerational instability in mice. Mutat. Res. 732, 21-25. PMID: 22289278. Voutounou M, Glen CD, Dubrova YE. 2012. The effects of methyl-donor deficiency on mutation induction and transgenerational instability in mice. Mutat. Res. 734, 1-4. PMID: 22569175. Mughal SK, Myazin AE, Zhavoronkov LP, Rubanovich AV, Dubrova YE. 2012. The dose and dose-rate effects of paternal irradiation on transgenerational instability in mice. A radiotherapy connection. PLoS ONE 7, e41300. PMID: 22911775. Glen CD, Dubrova YE. 2012. Exposure to anticancer drugs can result in transgenerational genomic instability in mice. Proc. Natl. Acad. Sci. USA 109, 2984-2988. PMID:22308437. Hardwick RJ, Tretyakov MV, Dubrova YE. 2009. Age-related accumulation of mutations supports a replication-dependent mechanism of spontaneous mutation at tandem repeat DNA loci in mice. Mol. Biol. Evol. 26, 2647-2654. PMID: 19679753 Barber RC, Hardwick RJ, Shanks ME, Glen CD, Mughal SK, Voutounou M, Dubrova YE. 2009. The effects of in utero irradiation on mutation induction and transgenerational instability in mice. Mutat. Res. 664, 6-12. PMID: 19428375 Shanks M, Riou L, Fouchet P, Dubrova YE. 2008. Stage-specificity of spontaneous mutation at a tandem repeat DNA locus in the mouse germline. Mutat. Res., 641, 58-60. PMID: 18423770 Glen CD, Smith AG, Dubrova YE. 2008. Single-molecule PCR analysis of germ line mutation induction by anticancer drugs in mice. Cancer Res., 68, 3630-3636. PMID: 18483245 Dubrova YE, Hickenbotham P, Glen, CD, Monger K, Wong H-P, Barber RC. 2008. Paternal exposure to ethylnitrosourea results in transgenerational genomic instability in mice. Environ. Mol. Mutagen. 49, 308-311. PMID: 18366099 Miccoli L, Burr KL-A, Hickenbotham P, Friedberg EC, Angulo JF, Dubrova YE. 2007. The combined effects of xeroderma pigmentosum C deficiency and mutagens on mutation rates in the mouse germline. Cancer Res., 67, 4695-4699. PMID: 17510396 Burr KL-A, van Duyn-Goedhart A, Hickenbotham P, Monger K, van Buul PPW, Dubrova YE. 2007. The effects of MSH2 deficiency on spontaneous and radiation-induced mutation rates in the mouse germline. Mutat. Res., 617, 147-151. PMID: 17331550 Hatch T, Derijck AAHA, Black PD, van der Heijden GW, De Boer P, Dubrova YE. 2007. Maternal effects of the scid mutation on radiation-induced transgenerational instability in mice. Oncogene, 26, 4720–4724. PMID: 17237807 Dubrova YE, Ploshchanskaya OG, Kozionova OS, Akleyev AV. 2006. Minisatellite germline mutation rate in the Techa River population. Mutat. Res., 602, 74-82. PMID: 16959276 Barber RC, Hickenbotham P, Hatch T, Kelly D, Topchiy N, Almeida G, Jones GGD, Johnson GE, Parry JM, Rothkamm K, Dubrova YE. 2006. Radiation-induced transgenerational alterations in genome stability and DNA damage. Oncogene, 25, 7336-7342. PMID: 16751800 Burr KL-A, Smith AG, Dubrova YE. 2005. p53 deficiency does not affect mutation rate in the mouse germline. Oncogene, 24, 4315-4318. PMID: 15806156 Dubrova YE. 2005. Radiation-induced mutation at tandem repeat DNA loci in the mouse germline: Spectra and doubling doses. Radiat. Res., 163, 200-207. PMID: 15658896 Barber RC, Miccoli L, van Buul PPW, Burr KL-A, van Duyn-Goedhart A, Angulo JF, Dubrova YE. 2004. Germline mutation rates at tandem repeat loci in DNA-repair deficient mice. Mutat. Res., 554, 287-295. PMID: 15450426 Dubrova YE. 2003. Radiation-induced transgenerational instability. Oncogene, 22, 7087-7093. PMID: 14557814 Vilarino-Guell C, Smith AG, Dubrova YE. 2003. Germline mutation induction at mouse repeat DNA loci by chemical mutagens. Mutat. Res., 526, 63-73. PMID: 12714184 Dubrova YE, Grant G, Chumak AA, Stezhka VA, Karakasian AN. 2002. Elevated minisatellite mutation rate in the post-Chernobyl families from Ukraine. Am. J. Hum. Genet., 71, 801-809. PMID: 12226793 Barber R, Plumb MA, Boulton E, Roux I, Dubrova YE. 2002. Elevated mutation rates in the germline of first- and second-generation offspring of irradiated male mice. Proc. Natl. Acad. Sci. USA, 99, 6877-6882. PMID: 11997464 Dubrova YE, Bersimbaev RI, Djansugurova LB, Tankimanova MK, Mamyrbaeva ZZ, Mustonen R, Lindholm C, Hultén M, Salomaa S. 2002. Nuclear weapons tests and human germline mutation rate. Science, 295, 1037. PMID: 11834827