Ketley , Julian - University of Leicester - School of Biological Sciences

个人简介

Julian Ketley went to the University of Birmingham to study biological sciences, specializing in microbiology. He stayed in Birmingham to complete his PhD in the Department of Microbiology, which was headed by Prof Harry Smith. Under the supervision of Dr John Stephen, Julian investigated the production and role of toxins A and B of Clostridium difficile. After obtaining his PhD in 1986, he left these shores for a postdoctoral position with Prof Jim Kaper at the Center for Vaccine Development, University of Maryland at Baltimore. Here he worked on the construction of the live Vibrio cholerae vaccine strain, CVD103HgR, and Zot toxin. Having been awarded a Royal Society University Research Fellowship, Julian returned to the UK, joining the Department of Genetics in 1990. He was awarded a personal Chair at the University of Leicester in 2001

研究领域

My research interests have focused predominantly on the molecular analysis of campylobacter jejuni and campylobacter coli with occasional excursions into other enteric pathogens

近期论文

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Xu F, Zeng X, Haigh RD, Ketley JM, Lin J: Identification and characterization of a new ferric enterobactin receptor, CfrB, in Campylobacter. J Bacteriol 2010, 192(17):4425-4435. Hartley-Tassell LE, Shewell LK, Day CJ, Wilson JC, Sandhu R, Ketley, JM, Korolik V: Identification and characterization of the aspartate chemosensory receptor of Campylobacter jejuni. Mol Microbiol 2010, 75(3):710 730. Miller CE, Williams PH, Ketley JM: Pumping iron: mechanisms for iron uptake by Campylobacter. Microbiology 2009, 155(Pt 10):3157-3165. Marsden GL, Li J, Everest PH, Lawson AJ, Ketley JM: Creation of a large deletion mutant of Campylobacter jejuni reveals that the lipooligosaccharide gene cluster is not required for viability. J Bacteriol 2009, 191(7):2392-2399. Miller CE, Rock JD, Ridley KA, Williams PH, Ketley JM: Utilization of lactoferrin-bound and transferrin-bound iron by Campylobacter jejuni. J Bacteriol 2008, 190(6):1900-1911. Cogan TA, Thomas AO, Rees LE, Taylor AH, Jepson MA, Williams PH, Ketley J, Humphrey TJ: Norepinephrine increases the pathogenic potential of Campylobacter jejuni. Gut 2007, 56(8):1060-1065. Ridley KA, Rock JD, Li Y, Ketley JM: Heme utilization in Campylobacter jejuni. J Bacteriol 2006, 188(22):7862-7875. Raphael BH, Pereira S, Flom GA, Zhang Q, Ketley JM, Konkel ME: The Campylobacter jejuni response regulator, CbrR, modulates sodium deoxycholate resistance and chicken colonization. J Bacteriol 2005, 187(11):3662-3670. Karlyshev AV, Ketley JM, Wren BW: The Campylobacter jejuni glycome. FEMS Microbiol Rev 2005, 29(2):377-390. Holmes K, Mulholland F, Pearson BM, Pin C, McNicholl-Kennedy J, Ketley JM, Wells JM: Campylobacter jejuni gene expression in response to iron limitation and the role of Fur. Microbiology 2005, 151(Pt 1):243-257. Van Vliet AH, Ketley JM, Park SF, Penn CW. (2002) The role of iron in Campylobacter gene regulation, metabolism and oxidative stress defense. FEMS Microbiol Rev. 26 :173-86. Matz C, van Vliet AH, Ketley JM, Penn CW. (2002) Mutational and transcriptional analysis of the Campylobacter jejuni flagellar biosynthesis gene flhB. Microbiology. 148 :1679-85. Oldfield NJ, Moran AP, Millar LA, Prendergast MM, Ketley JM. (2002) Characterization of the Campylobacter jejuni heptosyltransferase II gene, waaF, provides genetic evidence that extracellular polysaccharide is lipid A core independent. J Bacteriol. 184 :2100-7. Van Vliet AH, Baillon MA, Penn CW, Ketley JM. (2001) The iron-induced ferredoxin FdxA of Campylobacter jejuni is involved in aerotolerance. FEMS Microbiol Lett. 196 :189-93. Van Vliet AH, Rock JD, Madeleine LN, Ketley JM. (2000) The iron-responsive regulator Fur of Campylobacter jejuni is expressed from two separate promoters. FEMS Microbiol Lett. 188 :115-8.