Mitcheson, John - University of Leicester - School of Biological Sciences

个人简介

1988-1991 BSc. Joint Honours Physiology and Biochemistry, Kings College, London. 1991-1992 Wellcome Trust Research Assistant. Department of Physiology, University of Bristol. 1992-1995 MRC Ph.D. Studentship. Department of Physiology, University of Bristol. Thesis: The morphology and ionic currents of cardiac myocytes maintained in cell culture. 1995-1998 British Heart Foundation Postdoctoral Research Assistant. Department of Physiology, University of Bristol. Project – regulation of ionic currents in single isolated atrioventricular nodal cells by antiarrhythmic drugs. 1998-2000 Wellcome Prize Travelling Research Fellow. University of Utah, USA. Mentor Prof Mike Sanguinetti. Project: a structural basis for hERG channel block and drug induced long QT syndrome. 2000-2006 Lecturer, University of Leicester, Department of Cell Physiology and Pharmacology. 2006–2015 Reader, Department of Cell Physiology and Pharmacology, University of Leicester. 2015-present Reader, Department of Molecular Cell Biology, University of Leicester.

研究领域

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Nitric oxide signalling and role in cardiac health and disease. Mechanistic basis of cardiac arrhythmias. hERG and hEAG potassium channel structure and function. Cardiac ion channel pharmacology Heme regulation of ion channels. Calcium-calmodulin regulation of ion channels.