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Heparin and methionine oxidation promote the formation of apolipoprotein A-I amyloid comprising α-helical and β-sheet structures.Townsend, D.J., Hughes, E., Hussain, R., Siligardi, G., Baldock, S.J., Madine, J., Middleton, D.A. 19/12/2016 In: Biochemistry. Atomic details of the interactions of Glycosaminoglycans with amyloid-β fibrilsStewart, K., Hughes, E., Yates, E., Akien, G.R., Huang, T., Lima, M., Rudd, T., Guerrini, M., Hung, S., Radford, S., Middleton, D.A. 13/07/2016 In: Journal of the American Chemical Society. 138, 27, p. 8328-8331. 4 p. Novel stereoselective bufadienolides reveal new insights into the requirements for Na+, K+-ATPase inhibition by cardiotonic steroidsTang, H., Ruan, L., Tian, H., Liang, G., Ye, W., Hughes, E., Esmann, M., Fedosova, N.U., Chung, T., Tzen, J.T.C., Jiang, R., Middleton, D.A. 5/07/2016 In: Scientific Reports. 2016, 6, 10 p. Long-range effects of Na+ binding in Na,K-ATPase reported by ATPMiddleton, D.A., Fedosova, N.U., Esmann, M. 1/12/2015 In: Biochemistry. 54, 47, p. 7041-7047. 7 p. Comparisons with amyloid-β reveal an aspartate residue that stabilizes fibrils of the aortic amyloid peptide medinDavies, H., Madine, J., Middleton, D. 20/03/2015 In: Journal of Biological Chemistry. 290, p. 7791-7803. 13 p. Ligand orientation in a membrane-embedded receptor site revealed by solid-state NMR with paramagnetic relaxation enhancement.Whittaker, C., Patching, S., Esmann, M., Middleton, D. 7/03/2015 In: Organic and Biomolecular Chemistry . 13, 9, p. 2664-2668. 5 p. Structures, chemotaxonomic significance, cytotoxic and Na+, K+-ATPase inhibitory activities of new cardenolides from Asclepias curassavicaZhang, R., Tian, H., Tan, Y., Chung, T., Sun, X., Xia, X., Ye, W., Middleton, D.A., Fedosova, N., Esmann, M., Tzen, J.T.C., Jiang, R. 17/09/2014 In: Organic and Biomolecular Chemistry . 12, 44, p. 8919-8929. 11 p. Comparison of the structure and function of phospholamban and the Arginine-14 deficient mutant associated with dilated cardiomyopathyHughes, E., Middleton, D.A. 16/09/2014 In: PLoS ONE. 9, 9, 10 p. Synthesis of bufalin derivatives with inhibitory activity against prostate cancer cellsYuan, X., Tian, H., Li, J., Jin, L., Jiang, S., Liu, K.W., Luo, C., Middleton, D.A., Esmann, M., Ye, W., Jiang, R. 3/06/2014 In: Natural Product Research. 28, 11, p. 843-847. 5 p. Expression and purification of the aortic amyloid polypeptide medinDavies, H.A., Wilkinson, M.C., Gibson, R.P., Middleton, D.A. 06/2014 In: Protein Expression and Purification. 98, p. 32-37. 6 p. Heparin promotes the rapid fibrillization of a peptide with low intrinsic amyloidogenicityMadine, J., Davies, H.A., Hughes, E., Middleton, D.A. 17/12/2013 In: Biochemistry. 52, 50, p. 8984-8992. 9 p. Insights into the Molecular Architecture of a Peptide Nanotube Using FTIR and Solid-State NMR Spectroscopic Measurements on an Aligned SampleMiddleton, D.A., Madine, J., Castelletto, V., Hamley, I.W. 27/09/2013 In: Angewandte Chemie International Edition. 52, 40, p. 10537-10540. Probing the contacts of a low-affinity substrate with a membrane-embedded transport protein using 1H-13C cross-polarisation magic-angle spinning solid-state NMRPatching, S.G., Henderson, P.J.F., Sharples, D.J., Middleton, D.A. 03/2013 In: Molecular Membrane Biology. 30, 2, p. 129-37. 9 p. Site-specific identification of an aβ fibril-heparin interaction site by using solid-state NMR spectroscopyMadine, J., Pandya, M.J., Hicks, M.R., Rodger, A., Yates, E.A., Radford, S.E., Middleton, D.A. 21/12/2012 In: Angewandte Chemie International Edition. 51, 52, p. 13140-3. 4 p. Fibrils and nanotubes assembled from a modified amyloid-β peptide fragment differ in the packing of the same β-sheet building blocksMadine, J., Davies, H.A., Shaw, C., Hamley, I.W., Middleton, D.A. 21/03/2012 In: Chemical Communications. 48, 24, p. 2976-8. 3 p. Amyloid-derived peptide forms self-assembled monolayers on gold nanoparticle with a curvature-dependent β-sheet structureShaw, C.P., Middleton, D.A., Volk, M., Lévy, R. 28/02/2012 In: ACS Nano. 6, 2, p. 1416-26. 11 p. Solid-state NMR reveals differences in the packing arrangements of peptide aggregates derived from the aortic amyloid polypeptide medinDavies, H.A., Madine, J., Middleton, D.A. 01/2012 In: Journal of Family Psychology. 18, 1, p. 65-72. 8 p. The conformation of ATP within the Na,K-ATPase nucleotide site: a statistically constrained analysis of REDOR solid-state NMR dataMiddleton, D.A., Hughes, E., Esmann, M. 25/07/2011 In: Angewandte Chemie International Edition. 50, 31, p. 7041-4. 4 p. A study of the membrane association and regulatory effect of the phospholemman cytoplasmic domainHughes, E., Whittaker, C.A.P., Barsukov, I.L., Esmann, M., Middleton, D.A. 04/2011 In: Biochimica et Biophysica Acta (BBA) - Biomembranes. 1808, 4, p. 1021-31. 11 p. Solid-state NMR detection of 14N-13C dipolar couplings between amino acid side groups provides constraints on amyloid fibril architectureMiddleton, D.A. 02/2011 In: Journal of Family Psychology. 49, 2, p. 65-9. 5 p. Measurement of multiple torsional angles from one-dimensional solid-state NMR spectra: application to the conformational analysis of a ligand in its biological receptor siteEdwards, R., Madine, J., Fielding, L., Middleton, D.A. 14/11/2010 In: Journal of Family Psychology. 12, 42, p. 13999-4008. 10 p. Heparin-derived oligosaccharides interact with the phospholamban cytoplasmic domain and stimulate SERCA functionHughes, E., Edwards, R., Middleton, D.A. 22/10/2010 In: Biochemical and Biophysical Research Communications. 401, 3, p. 370-5. 6 p. Comparison of aggregation enhancement and inhibition as strategies for reducing the cytotoxicity of the aortic amyloid polypeptide medinMadine, J., Middleton, D.A. 08/2010 In: Journal of Family Psychology. 39, 9, p. 1281-8. 8 p. Evaluation of beta-alanine- and GABA-substituted peptides as inhibitors of disease-linked protein aggregationMadine, J., Wang, X., Brown, D.R., Middleton, D.A. 17/08/2009 In: Journal of Family Psychology. 10, 12, p. 1982-7. 6 p. Inhibitors of protein aggregation and toxicityAmijee, H., Madine, J., Middleton, D.A., Doig, A.J. 08/2009 In: Biochemical Society Transactions. 37, Pt 4, p. 692-6. 5 p.