Ashton, Lorna - Lancaster University - Department of Chemistry

研究领域

My area of interest is the advancement of Raman spectroscopy as an analytical tool for monitoring physiochemical properties of molecules. My research involves combining Raman spectroscopy and chemometric methods for the identification of structural changes due to post-translational modifications, protein-protein interactions, ligand binding and changes in protein stability as well as working towards on-line monitoring of biopharmaceutical products, substrates and by-products. Furthermore, I am developing Raman micro-spectroscopy techniques to image live cells during abiotic perturbations

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Detection of glycosylation and iron-binding protein modifications using Raman spectroscopyAshton, L., Brewster, V., Correa, E., Goodacre, R. 1/02/2017 In: The Analyst. Two-dimensional codistribution spectroscopy applied to UVRR and ROA investigations of biomolecular transitionsRamer, G., Ashton, L. 15/11/2016 In: Journal of Molecular Structure. 1124, p. 173-179. 7 p. Raman spectroscopy: an evolving technique for live cell studiesSmith, R., Wright, K.L., Ashton, L. 21/06/2016 Using Raman spectroscopy to characterize biological materialsButler, H.J., Ashton, L., Bird, B., Cinque, G., Curtis, K., Dorney, J., Esmonde-White, K., Fullwood, N.J., Gardner, B., Martin-Hirsch, P.L., Walsh, M.J., McAinsh, M.R., Stone, N., Martin, F.L. 04/2016 In: Nature Protocols. 11, 4, p. 664-687. 24 p. Detection of protein glycosylation using tip enhanced Raman scatteringCowcher, D., Deckert-Gaudig, T., Brewster, V., Ashton, L., Deckert, V., Goodacre, R. 16/02/2016 In: Analytical Chemistry. 88, 4, p. 2105-2112. 8 p. Detection of early stage changes associated with adipogenesis using Raman spectroscopy under aseptic conditionsMitchell, A., Ashton, L., Yang, X.B., Goodacre, R., Smith, A., Kirkham, J. 6/10/2015 In: Cytometry Part A. Aseptic Raman spectroscopy can detect changes associated with the culture of human dental pulp stromal cells in osteoinductive cultureMitchell, A., Ashton, L., Yang, X.B., Goodacre, R., Tomlinson, M.J., Smith, A., Kirkham, J. 10/09/2015 In: The Analyst. 140, 21, p. 7347-7354. 8 p. Making colourful sense of Raman images of single cellsAshton, L., Hollyowood, K., Goodacre, R. 21/03/2015 In: The Analyst. 140, 6, p. 1852-1858. 7 p. UV resonance Raman spectroscopy: a process analytical tool for host cell DNA and RNA dynamics in mammalian cell linesAshton, L., Hogwood, C.E.M., Tait, A.S., Kuligowski, J., Smales, C.M., Bracewell, D.G., Dickson, A.J., Goodacre, R. 02/2015 In: Journal of Chemical Technology and Biotechnology. 90, 2, p. 237-243. 7 p. Monitoring antibody aggregation in early drug development using Raman spectroscopy and perturbation-correlation moving windowsGómez de la Cuesta, R., Goodacre, R., Ashton, L. 18/11/2014 In: Analytical Chemistry. 86, 22, p. 11133-11140. 8 p. Investigation of DMSO-induced conformational transitions in human serum albumin using two-dimensional Raman optical activity spectroscopyBatista, A.N.L., Batista, J.M., Ashton, L., Bolzani, V.S., Furlan, M., Blanch, E.W. 09/2014 In: Chirality. 26, 9, p. 497-501. 5 p. Raman spectroscopy can characterise the early stages of osteoinduction in dental pulp stromal cellsMighell, A., Ashton, L., Yang, X., Smith, A., Kirkham, J. 06/2014 Understanding glycoprotein behaviours using Raman and Raman optical activity spectroscopies: characterising the entanglement induced conformational changes in oligosaccharide chains of mucinAshton, L., Pudney, P.D.A., Blanch, E.W., Yakubov, G.E. 11/2013 In: Advances in Colloid and Interface Science. 199-200, p. 66-77. 12 p. The challenge of applying Raman spectroscopy to monitor recombinant antibody productionAshton, L., Xu, Y., Brewster, V.L., Cowcher, D.P., Sellick, C.A., Dickson, A.J., Stephens, G.M., Goodacre, R. 26/09/2013 In: The Analyst. 138, 22, p. 6977-6985. 9 p. Monitoring Guanidinium-Induced Structural Changes in Ribonuclease Proteins Using Raman Spectroscopy and 2D Correlation AnalysisBrewster, V.L., Ashton, L., Goodacre, R. 2/04/2013 In: Analytical Chemistry. 85, 7, p. 3570-3575. 6 p. Illuminating disease and enlightening biomedicine: Raman spectroscopy as a diagnostic toolEllis, D.I., Cowcher, D.P., Ashton, L., O'Hagan, S., Goodacre, R. 2013 The importance of protonation in the investigation of protein phosphorylation using Raman spectroscopy and Raman optical activityAshton, L., Johannessen, C., Goodacre, R. 15/10/2011 In: Analytical Chemistry. 83, 20, p. 7978-7983. 6 p. Raman spectroscopy: lighting up the future of microbial identificationAshton, L., Lau, K., Winder, C.L., Goodacre, R. 09/2011 In: Future Microbiology. 6, 9, p. 991-997. 7 p. Monitoring the glycosylation status of proteins using Raman spectroscopyBrewster, V.L., Ashton, L., Goodacre, R. 1/08/2011 In: Analytical Chemistry. 83, 15, p. 6074-6081. 8 p. Structural, spectroscopic and redox properties of uranyl complexes with a maleonitrile containing ligandHardwick, H.C., Royal, D.S., Helliwell, M., Pope, S.J.A., Ashton, L., Goodacre, R., Sharrad, C.A. 2011 In: Dalton Transactions. 40, 22, p. 5939-5952. 14 p. pH-induced conformational transitions in alpha-lactalbumin investigated with two-dimensional Raman correlation variance plots and moving windowsAshton, L., Blanch, E.W. 16/06/2010 In: Journal of Molecular Structure. 974, 1-3, p. 132-138. 7 p. Susceptibility of different proteins to flow-induced conformational changes monitored with Raman spectroscopyAshton, L., Dusting, J., Imomoh, E., Balabani, S., Blanch, E.W. 17/02/2010 In: Biophysical Journal. 98, 4, p. 707-714. 8 p. Shear-induced unfolding of lysozyme monitored in situAshton, L., Dusting, J., Imomoh, E., Balabani, S., Blanch, E.W. 20/05/2009 In: Biophysical Journal. 96, 10, p. 4231-4236. 6 p. Investigations of conformational transitions in proteins and RNA using 2DCOS Raman and 2DCOS Raman optical activity spectroscopiesAshton, L., Hobro, A., Conn, G.L., Rouhi, M., Blanch, E.W. 30/07/2008 In: Journal of Molecular Structure. 883-884, p. 187-194. 8 p. Investigation of polypeptide conformational transitions with two-dimensional Raman optical activity correlation analysis, applying autocorrelation and moving window approachesAshton, L., Blanch, E.W. 05/2008 In: Applied Spectroscopy. 62, 5, p. 469-475. 7 p.