Taylor, Elaine - Lancaster University

研究领域

My research interests are in understanding how cells maintain genome integrity and, in particular, in understanding the role played by ubiquitin and SUMO modification in this process. Through a combination of biochemical analysis, using purified proteins and cell-free extracts of Xenopus laevis eggs, and in vivo cell biological analysis using established human cell lines, my group is identifying key targets of ubiquitin and SUMO modification in the DNA damage response

近期论文

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PrimPol bypasses UV photoproducts during chromosomal DNA replicationBianchi, J., Rudd, S.G., Jozwiakowski, S.K., Bailey, L.J., Soura, V., Taylor, E., Stevanovic, I., Green, A.J., Stracker, T.H., Lindsay, H., Doherty, A.J. 21/11/2013 In: Molecular Cell. 52, 4, p. 566-573. 8 p. Depletion of Uhrf1 inhibits chromosomal DNA replication in Xenopus egg extractsTaylor, E., Bonsu-Dartnall, N., Price, J., Lindsay, H. 20/06/2013 In: Nucleic Acids Research. 41, 16, p. 7725-7737. 13 p. The Mre11/Rad50/Nbs1 complex functions in resection-based DNA end joining in Xenopus laevis.Taylor, E.M., Cecillon, S.M., Bonis, A., Chapman, J.R., Povirk, L.F., Lindsay, H.D. 01/2010 In: Nucleic Acids Research. 38, 2, p. 441-454. 14 p. Identification of the proteins, including MAGE-G1, that make up the human SMC5-6 protein complex.Taylor, E.M., Copsey, A., Hudson, J., Vidot, S., Lehmann, A. 15/02/2008 In: Molecular and Cellular Biology. 28, 4, p. 1197-1206. 10 p. Composition and architecture of the Schizosaccharomyces pombe Rad18 (Smc5-6) complex.Sergeant, J., Taylor, E., Palecek, J., Fousteri, M., Andrews, E., Sweeney, S., Shinagawa, H., Watts, F. 01/2005 In: Molecular and Cellular Biology. 25, 1, p. 172-184. 13 p. Nse2, a component of the Smc5-6 complex, is a SUMO ligase required for the response to DNA damage.Andrews, E., Palecek, J., Sergeant, J., Taylor, E., Lehmann, A., Watts, F. 01/2005 In: Molecular and Cellular Biology. 25, 1, p. 185-196. 12 p.