Lindsay, Howard - Lancaster University

研究领域

My main research interests are the mechanisms that maintain genome stability, in particular the cellular responses to DNA damage and DNA replication stress.

近期论文

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DNA replication stress and cancer: cause or cure?Taylor, E.M., Lindsay, H.D. 01/2016 In: Future Oncology. 12, 2, p. 221-237. 17 p. PrimPol bypasses UV photoproducts during chromosomal DNA replicationBianchi, J., Rudd, S.G., Jozwiakowski, S.K., Bailey, L.J., Soura, V., Taylor, E., Stevanovic, I., Green, A.J., Stracker, T.H., Lindsay, H., Doherty, A.J. 21/11/2013 In: Molecular Cell. 52, 4, p. 566-573. 8 p. Depletion of Uhrf1 inhibits chromosomal DNA replication in Xenopus egg extractsTaylor, E., Bonsu-Dartnall, N., Price, J., Lindsay, H. 20/06/2013 In: Nucleic Acids Research. 41, 16, p. 7725-7737. 13 p. The Mre11/Rad50/Nbs1 complex functions in resection-based DNA end joining in Xenopus laevis.Taylor, E.M., Cecillon, S.M., Bonis, A., Chapman, J.R., Povirk, L.F., Lindsay, H.D. 01/2010 In: Nucleic Acids Research. 38, 2, p. 441-454. 14 p. A direct requirement for Xmus101 in ATR-mediated phosphorylation of Claspin bound Chk1 during checkpoint signaling.Yan, S., Lindsay, H.D., Michael, W.M. 04/2006 In: Journal of Cell Biology. 173, 2, p. 181-186. 6 p. Delineating the position of rad4+/cut5+ within the DNA-structure checkpoint pathways in Schizosaccharomyces pombe.Harris, S., Kemplen, C., Caspari, T., Chan, C., Lindsay, H.D., Poitelea, M., Carr, A.M., Price, C. 1/09/2003 In: Journal of Cell Science. 116, 17, p. 3519-3529. 11 p. Molecular Characterization of the Schizosaccharomyces pombe nbs1+ Gene Involved in DNA Repair and Telomere Maintenance.Ueno, M., Nakazaki, T., Akamatsu, Y., Watanabe, K., Tomita, K., Lindsay, H.D., Shinagawa, H., Iwasaki, H. 09/2003 In: Molecular and Cellular Biology. 23, 18, p. 6553-6563. 11 p. XRad17 Is Required for the Activation of XChk1 But Not XCds1 during Checkpoint Signaling in Xenopus.Jones, R.E., Chapman, J.R., Puligilla, C., Murray, J.M., Car, A.M., Ford, C.C., Lindsay, H.D. 2003 In: Molecular Biology of the Cell. 14, 9, p. 3898-3910. 13 p. DNA replication is required for the checkpoint response to damaged DNA in Xenopus egg extracts.Stokes, M.P., Van Hatten, R., Lindsay, H.D., Michael, W.M. 09/2002 In: Journal of Cell Biology. 158, 5, p. 863-872. 10 p. Characterization of Schizosaccharomyces pombe Hus1: a PCNA-Related Protein That Associates with Rad1 and Rad9.Caspari, T., Dahlen, M., Kanter-Smoler, G., Lindsay, H.D., Hofmann, K., Papadimitriou, K., Sunnerhagen, P., Carr, A.M. 02/2000 In: Molecular and Cellular Biology. 20, 4, p. 1254-1262. 9 p. Rad18 Is Required for DNA Repair and Checkpoint Responses in Fission Yeast.Verkade, H.M., Bugg, S.J., Lindsay, H.D., Carr, A.M., O'Connell, M.J. 09/1999 In: Molecular Biology of the Cell. 10, 9, p. 2905-2918. 14 p. Analysis of Rad3 and Chk1 protein kinases defines different checkpoint responses.Martinho, R.G., Lindsay, H.D., Flaggs, G., DeMaggio, A.J., Hoekstra, M.F., Carr, A.M., Bentley, N.J. 15/12/1998 In: EMBO Journal. 17, 24, p. 7239-7249. 11 p. S-phase-specific activation of Cds1 kinase defines a subpathway of the checkpoint response in Schizosaccharomyces pombe.Lindsay, H.D., Griffiths, D.J.F., Edwards, R.J., Christensen, P.U., Murray, J.M., Osman, F., Walworth, N., Carr, A.M. 1/02/1998 In: Genes and Development. 12, 3, p. 382-395. 14 p. Post-translational activation of non-homologous DNA end-joining in Xenopus oocyte extracts.Aoufouchi, S., Patrick, T., Lindsay, H.D., Shall, S., Ford, C.C. 07/1997 In: FEBS Journal. 247, 2, p. 518-525. 8 p. Dissection of the cell cycle using cell-free extracts from Xenopus laevisFord, C., Lindsay, H. 3/04/1996 In: Advances in molecular and cell biology. Elsevier Science Ltd. p. 117-211. 95 p. Calcium requirements during mitotic cdc2 kinase activation and cyclin degradation in Xenopus egg extracts.Lindsay, H.D., Whitaker, M.J., Ford, C.C. 11/1995 In: Journal of Cell Science. 108, 11, p. 3557-3568. 12 p.