Worthington, John - Lancaster University - The Division of Biomedical and Life Sciences

个人简介

After receiving my BSc in Biology from Nottingham University in 2002, I became a Research Technician in Professor Grencis' lab at The University of Manchester. I soon became fascinated with host-parasite interactions of the enteric environment and after completing a short research technician post in endocrinology went on to pursue a PhD in 2004, under the supervision of Professor John McLaughlin. After receiving my PhD in 2008, entitled 'Molecular mechanisms of the gut immune systems and effects on nutrient sensing cells', I joined the lab of Dr Mark Travis in the Wellcome Trust Centre for Cell Matrix Research, examining the role of the integrin avß8 on dendritic cells during infection and autoimmunity. I moved with Mark to the newly established Manchester Collaborative Centre for Inflammation Research in 2012 for a second post-doc, establishing an essential role for avß8 integrin on regulatory T cells during autoimmunity. In 2014, I was awarded a Wellcome Trust funded stepping stones fellowship at Manchester to help establish my own lab, before accepting a lectureship in Infection Biology at Lancaster University in 2016.

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Escitalopram affects spexin expression in the rat hypothalamus, hippocampus and striatumPalasz, A., Suszka-?witek, A., Filipczyk, L., Bogus, K., Rojczyk, E., Worthington, J.J., Krzystanek, M., Wiaderkiewicz, R. 12/2016 In: Pharmacological reports : PR. 68, 6, p. 1326-1331. 6 p. Inflammatory cues enhance TGFβ activation by distinct subsets of human intestinal dendritic cells via integrin αvβ8Fenton, T.M., Kelly, A., Shuttleworth, E.E., Smedley, C., Atakilit, A., Powrie, F., Campbell, S., Nishimura, S.L., Sheppard, D., Levison, S., Worthington, J.J., Lehtinen, M.J., Travis, M.A. 26/10/2016 In: Mucosal Immunology. Extended neuroleptic administration modulates NMDA-R subunit immunoexpression in the rat neocortex and diencephalonKrzystanek, M., Bogus, K., Palasz, A., Wiaderkiewicz, A., Filipczyk, L., Rojczyk, E., Worthington, J.J., Wiaderkiewicz, R. 10/2016 In: Pharmacological reports : PR. 68, 5, p. 990-995. 6 p. Tuft cells: a new flavor in innate epithelial immunityGrencis, R.K., Worthington, J.J. 08/2016 In: Trends in Parasitology. 32, 8, p. 583-585. 3 p. Long-term treatment with haloperidol affects neuropeptide S and NPSR mRNA levels in the rat brainPalasz, A., Rojczyk, E., Golyszny, M., Filipczyk, L., Worthington, J.J., Wiaderkiewicz, R. 04/2016 In: Acta Neuropsychiatrica. 28, 2, p. 110-116. 7 p. Effects of long-term treatment with the neuroleptics haloperidol, clozapine and olanzapine on immunoexpression of NMDA receptor subunits NR1, NR2A and NR2B in the rat hippocampusKrzystanek, M., Bogus, K., Pa?asz, A., Krzystanek, E., Worthington, J.J., Wiaderkiewicz, R. 10/2015 In: Pharmacological reports : PR. 67, 5, p. 965-969. 5 p. The intestinal immunoendocrine axis: novel cross-talk between enteroendocrine cells and the immune system during infection and inflammatory diseaseWorthington, J.J. 3/08/2015 In: Biochemical Society Transactions. 43, 4, p. 727-733. 7 p. Effector Tregs: middle-men in TGFβ activationWorthington, J.J., Travis, M.A. 27/06/2015 In: Oncotarget. 6, 24, 2 p. Integrin αvβ8-mediated TGF-β activation by effector regulatory T sells is essential for suppression of T-Cell-mediated inflammationWorthington, J.J., Kelly, A., Smedley, C., Bauché, D., Campbell, S., Marie, J.C., Travis, M.A. 19/05/2015 In: Immunity. 42, 5, p. 903-915. 13 p. The novel neuropeptide phoenixin is highly co-expressed with nesfatin-1 in the rat hypothalamus, an immunohistochemical studyPa?asz, A., Rojczyk, E., Bogus, K., Worthington, J.J., Wiaderkiewicz, R. 10/04/2015 In: Neuroscience Letters. 592, p. 17-21. 5 p. Chronic Trichuris muris infection in C57BL/6 mice causes significant changes in most microbiota and metabolome: effects reversed by pathogen clearanceHoulden, A., Hayes, K.S., Bancroft, A.J., Worthington, J.J., Wang, P., Grencis, R.K., Roberts, I.S. 25/03/2015 In: PLoS ONE. 10, 5, 25 p. Neurolight -astonishing advances in brain imagingRojczyk-Go??biewska, E., Pa?asz, A., Worthington, J.J., Markowski, G., Wiaderkiewicz, R. 02/2015 In: The International Journal of Neuroscience. 125, 2, p. 91-99. 9 p. Mesenchymal stromal cells: inhibiting PDGF receptors or depleting fibronectin induces mesodermal progenitors with endothelial potentialBall, S.G., Worthington, J.J., Canfield, A.E., Merry, C.L.R., Kielty, C.M. 03/2014 In: Stem Cells. 32, 3, p. 694-705. 12 p. Adaptive immunity alters distinct host feeding pathways during nematode induced inflammation, a novel mechanism in parasite expulsionWorthington, J.J., Samuelson, L.C., Grencis, R.K., McLaughlin, J.T. 17/01/2013 In: PLoS Pathogens. 9, 1, 8 p. Loss of the TGFβ-activating integrin αvβ8 on dendritic cells protects mice from chronic intestinal parasitic infection via control of type 2 immunityWorthington, J.J., Klementowicz, J.E., Rahman, S., Czajkowska, B.I., Smedley, C., Waldmann, H., Sparwasser, T., Grencis, R.K., Travis, M.A. 2013 In: PLoS Pathogens. 9, 10, 12 p. Regulation of TGFβ in the immune system: an emerging role for integrins and dendritic cellsWorthington, J.J., Fenton, T.M., Czajkowska, B.I., Klementowicz, J.E., Travis, M.A. 12/2012 In: Immunobiology. 217, 12, p. 1259-1265. 7 p. Nesfatin-1, a unique regulatory neuropeptide of the brainPalasz, A., Krzystanek, M., Worthington, J., Czajkowska, B., Kostro, K., Wiaderkiewicz, R., Bajor, G. 06/2012 Intestinal dendritic cells specialize to activate transforming growth factor-β and induce Foxp3+ regulatory T cells via integrin αvβ8Worthington, J.J., Czajkowska, B.I., Melton, A.C., Travis, M.A. 11/2011 In: Gastroenterology. 141, 5, p. 1802-1812. 11 p. Trichinella spiralis antigens prime mixed Th1/Th2 response but do not induce de novo generation of Foxp3+ T cells in vitroIlic, N., Worthington, J.J., Gruden-Movsesijan, A., Travis, M.A., Sofronic-Milosavljevic, L., Grencis, R.K. 10/2011 In: Parasite Immunology. 33, 10, p. 572-582. 11 p. TGFβ: a sleeping giant awoken by integrinsWorthington, J.J., Klementowicz, J.E., Travis, M.A. 01/2011 In: Trends in Biochemical Sciences. 36, 1, p. 47-54. 8 p. Enteroendocrine cells: neglected players in gastrointestinal disorders?Moran, G.W., Leslie, F.C., Levison, S.E., Worthington, J., McLaughlin, J.T. 07/2008 In: Therapeutic Advances in Gastroenterology. 1, 1, p. 51-60. 10 p. Seasonal changes in peptide, receptor and ion channel mRNA expression in the caudal neurosecretory system of the European flounder (Platichthys flesus)Lu, W., Worthington, J., Riccardi, D., Balment, R.J., McCrohan, C.R. 15/06/2007 In: General and Comparative Endocrinology. 153, 1-3, p. 262-272. 11 p. Effects of radio-frequency fields on bacterial cell membranes and nematode temperature-sensitive mutantsGul Guven, R., Guven, K., Dawe, A., Worthington, J., Harvell, C., Popple, A., Smith, T., Smith, B., de Pomerai, D.I. 2/08/2006 In: Enzyme and Microbial Technology. 39, 4, p. 788-795. 8 p. Molecular characterization and expression of urotensin II and its receptor in the flounder (Platichthys flesus): a hormone system supporting body fluid homeostasis in euryhaline fishLu, W., Greenwood, M., Dow, L., Yuill, J., Worthington, J., Brierley, M.J., McCrohan, C.R., Riccardi, D., Balment, R.J. 08/2006 In: Clinical Endocrinology. 147, 8, p. 3692-708. 17 p. WSX-1: a key role in induction of chronic intestinal nematode infectionBancroft, A.J., Humphreys, N.E., Worthington, J.J., Yoshida, H., Grencis, R.K. 15/06/2004 In: Journal of Immunology. 172, 12, p. 7635-7641. 7 p.