Unterholzner, Leonie - Lancaster University - The Division of Biomedical and Life Sciences

研究领域

My research group is interested in how cells can detect foreign DNA, for example when skin cells have been infected by a virus. This is part of the innate immune response, which acts within the first few hours of infection, with the aim to alert more specialised immune cells, and to eliminate the virus before it can spread to other parts of the body. We are investigating how a cell can distinguish viral DNA from its own DNA genome, and how it signals to alert neighbouring cells. We also study how cells can detect their own DNA as danger signal, when the DNA has been damaged by UV light or chemotherapy.

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The interferon response to intracellular DNA: why so many receptors?Unterholzner, L. 11/2013 In: Immunobiology. 218, 11, p. 1312-1321. 10 p. Proteasomal degradation of herpes simplex virus capsids in macrophages releases DNA to the cytosol for recognition by DNA sensorsHoran, K.A., Hansen, K., Jakobsen, M.R., Holm, C.K., S?by, S., Unterholzner, L., Thompson, M., West, J.A., Iversen, M.B., Rasmussen, S.B., Ellermann-Eriksen, S., Kurt-Jones, E., Landolfo, S., Damania, B., Melchjorsen, J., Bowie, A.G., Fitzgerald, K.A., Paludan, S.R. 1/03/2013 In: Journal of Immunology. 190, 5, p. 2311-2319. 9 p. Poxvirus targeting of E3 ligase β-TrCP by molecular mimicry: a mechanism to inhibit NF-κB activation and promote immune evasion and virulenceMansur, D.S., Maluquer de Motes, C., Unterholzner, L., Sumner, R.P., Ferguson, B.J., Ren, H., Strnadova, P., Bowie, A.G., Smith, G.L. 02/2013 In: PLoS Pathogens. 9, 2 Structures of the HIN domain:DNA complexes reveal ligand binding and activation mechanisms of the AIM2 inflammasome and IFI16 receptorJin, T., Perry, A., Jiang, J., Smith, P., Curry, J.A., Unterholzner, L., Jiang, Z., Horvath, G., Rathinam, V.A., Johnstone, R.W., Hornung, V., Latz, E., Bowie, A.G., Fitzgerald, K.A., Xiao, T.S. 20/04/2012 In: Immunity. 36, 4, p. 561-571. 11 p. Vaccinia virus protein C6 is a virulence factor that binds TBK-1 adaptor proteins and inhibits activation of IRF3 and IRF7Unterholzner, L., Sumner, R.P., Baran, M., Ren, H., Mansur, D.S., Bourke, N.M., Randow, F., Smith, G.L., Bowie, A.G. 09/2011 In: PLoS Pathogens. 7, 9 Innate DNA sensing moves to the nucleusUnterholzner, L., Bowie, A.G. 19/05/2011 In: Cell Host and Microbe. 9, 5, p. 351-353. 3 p. IFI16 is an innate immune sensor for intracellular DNAUnterholzner, L., Keating, S.E., Baran, M., Horan, K.A., Jensen, S.B., Sharma, S., Sirois, C.M., Jin, T., Latz, E., Xiao, T.S., Fitzgerald, K.A., Paludan, S.R., Bowie, A.G. 11/2010 In: Nature Immunology. 11, 11, p. 997-1004. 8 p. Viral evasion and subversion of pattern-recognition receptor signallingBowie, A.G., Unterholzner, L. 12/2008 In: Nature Immunology. 8, 12, p. 911-922. 12 p. The interplay between viruses and innate immune signaling: recent insights and therapeutic opportunitiesUnterholzner, L., Bowie, A.G. 1/02/2008 In: Biochemical Pharmacology. 75, 3, p. 589-602. 14 p. SMG7 is a 14-3-3-like adaptor in the nonsense-mediated mRNA decay pathwayFukuhara, N., Ebert, J., Unterholzner, L., Lindner, D., Izaurralde, E., Conti, E. 18/02/2005 In: Molecular Cell. 17, 4, p. 537-547. 11 p. SMG7 acts as a molecular link between mRNA surveillance and mRNA decayUnterholzner, L., Izaurralde, E. 19/11/2004 In: Molecular Cell. 16, 4, p. 587-596. 10 p. Molecular insights into the interaction of PYM with the Mago-Y14 core of the exon junction complexBono, F., Ebert, J., Unterholzner, L., Güttler, T., Izaurralde, E., Conti, E. 03/2004 In: EMBO Reports. 5, 3, p. 304-310. 7 p. Nonsense-mediated mRNA decay in Drosophila: at the intersection of the yeast and mammalian pathwaysGatfield, D., Unterholzner, L., Ciccarelli, F.D., Bork, P., Izaurralde, E. 1/08/2003 In: EMBO Journal. 22, 15, p. 3960-3970. 11 p.