Shirras, Alan - Lancaster University - The Division of Biomedical and Life Sciences

研究领域

Mammalian angiotensin I-converting enzyme (ACE) is a zinc metallopeptidase that cleaves dipeptides from the C-terminus of oligopeptides and is best known for its pivotal role in blood homeostasis, as part of the Renin-Angiotensin and Kinin-Kininogen systems. ACE activity is also found in invertebrates from several phyla, including all insect species studied so far. Since invertebrates do not possess peptide hormones structurally related to angiotensin, bradykinin and N-acetylSDKP, understanding the physiological roles of these invertebrate ACEs is likely to reveal novel functions of ACE-like peptidases in biological processes. Two Drosophila homologues of human ACE (ANCE and ACER) have been the subject of genetic and biochemical studies in our labs.

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Development of a real-time qPCR assay for quantification of covert baculovirus infections in a major african crop pestGraham, R.I., Tummala Munuswamy, Y., Rhodes, G., Cory, J.S., Shirras, A.D., Grzywacz, D., Wilson, K. 25/08/2015 In: Insects. 6, 3, p. 746-759. 14 p. The Drosophila insulin receptor independently modulates lifespan and locomotor senescenceHodges, M., Haji Ismail, M.Z.B., Boylan, M., Achall , R., Shirras, A., Broughton, S. 28/05/2015 In: PLoS ONE. A stress-specific calcium signature regulating an ozone-responsive gene expression network in ArabidopsisMcAinsh, M., Short, E., North, K., Roberts, M., Shirras, A., Hetherington, A. 9/07/2012 In: The Plant Journal. 71, 6, p. 948–961. 14 p. lemmingA encodes the Apc11 subunit of the APC/C in Drosophila melanogaster that forms a ternary complex with the E2-C type ubiquitin conjugating enzyme, Vihar and Morula/Apc2Nagy, O., Pal, M., Udvardy, A., Shirras, C.A.M., Boros, I., Shirras, A.D., Deak, P. 14/03/2012 In: Cell Division. 7, n/a, 16 p. Cytoplasmic male sterility in Drosophila melanogaster associated with a mitochondrial CYTB variantClancy, D.J., Hime, G.R., Shirras, A.D. 10/2011 In: Heredity. 107, 4, 3 p. Loss of Angiotensin-converting enzyme-related (ACER) peptidase disrupts night-time sleep in adult Drosophila melanogasterCarhan, A., Tang, K., Shirras, C.A., Shirras, A.D., Isaac, R.E. 02/2011 In: Journal of Experimental Biology. 214, 4, p. 680-686. 7 p. Drosophila male sex peptide inhibits siesta sleep and promotes locomotor activity in the post-mated femaleIsaac, R.E., Li, C., Leedale, A.E., Shirras, A.D. 7/01/2010 In: Proceedings of the Royal Society B: Biological Sciences. 277, 1678, p. 65-70. 6 p. Neuropeptidases and the metabolic inactivation of insect neuropeptidesIsaac, R.E., Bland, N.D., Shirras, A.D. 15/05/2009 In: General and Comparative Endocrinology. 162, 1, p. 8-17. 10 p. Locomotor and geotactic behavior of Drosophila melanogaster over-expressing neprilysin 2Bland, N.D., Robinson, P., Thomas, J.E., Shirras, A.D., Turner, A.J., Isaac, R.E. 03/2009 In: Peptides. 30, 3, p. 571-574. 4 p. Increased fragmentation of night-time sleep in Drosophila melanogaster lacking the angiotensin-converting enzyme-related (ACER) peptidaseIsaac, E., Carhan, A., Tang, K., Shirras, C., Shirras, A. 2009 Metabolic inactivation of the circadian transmitter, pigment dispersing factor (PDF), by neprilysin-like peptidases in Drosophila.Isaac, R.E., Johnson, E.C., Audsley, N., Shirras, A.D. 15/12/2007 In: Journal of Experimental Biology. 210, 24, p. 4465-4470. 6 p. Male accessory glands of Drosophila melanogaster make a secreted angiotensin I-converting enzyme (ANCE), suggesting a role for the peptide-processing enzyme in seminal fluid.Rylett, C.M., Walker, M.J., Howell, G.J., Shirras, A.D., Isaac, R.E. 15/10/2007 In: Journal of Experimental Biology. 210, 20, p. 3601-3606. 6 p. An unsuspected ecdysteroid/steroid phosphatase activity in the key T-cell regulator, Sts-1: Surprising relationship to insect ecdysteroid phosphate phosphataseDavies, L., Anderson, I.P., Turner, P.C., Shirras, A.D., Rees, H.H., Rigden, D.J. 15/04/2007 In: Proteins: Structure, Function, and Bioinformatics. 67, 3, p. 720-731. 12 p. Angiotensin-converting enzyme as a target for the development of novel insect growth regulators.Isaac, R.E., Lamango, N.S., Ekbote, U., Taylor, C.A., Hurst, D., Weaver, R.J., Carhan, A., Burnham, S., Shirras, A.D. 01/2007 In: Peptides. 28, 1, p. 153-162. 10 p. Expression of NEP2, a soluble neprilysin-like endopeptidase, during embryogenesis in Drosophila melanogaster.Bland, N.D., Thomas, J.E., Audsley, N., Shirras, A.D., Turner, A.J., Isaac, R.E. 01/2007 In: Peptides. 28, 1, p. 127-135. 9 p. Proteomic identification of Drosophila melanogaster male accessory gland proteins, including a pro-cathepsin and a soluble gamma-glutamyl transpeptidase.Walker, M.J., Rylett, C.M., Keen, J.N., Audsley, N., Sajid, M., Shirras, A.D., Isaac, R.E. 2/05/2006 In: Proteome Science. 4, p. 9. Effect of hight rhizospheric calcium on root growth and structure in Arabidopsis.Cherukuri, S., McAinsh, M., Shirras, A. 04/2006 In: Comparative Biochemistry and Physiology - Part A: Molecular and Integrative Physiology. 143, 4 Supp, p. S178. Structural diversity of angiotensin-converting enzyme : insights from structure-activity comparisons of two Drosophila enzymes.Bingham, R.D., Dive, V., Phillips, S.E.V., Shirras, A.D., Isaac, R.E. 01/2006 In: FEBS Journal. 273, 2, p. 362-373. 12 p. Environmental genomics of calcicole-calcifuge physiology.Abram, B., Cherukuri, C., Pritchard, S.C., Rodwell, J.S., Shirras, A.D., McAinsh, M. 07/2005 In: Comparative Biochemistry and Physiology - Part A: Molecular and Integrative Physiology. 141, 3 Supp, p. S276-S277. Expression and function of proctolin in DrosophilaShirras, A.D., Taylor, C.A.M., Nassel, D.R., Coast, G.M., Isaac, R.E. 07/2005 Functional genomics of ozone stress in Arabidopsis.Short, E., Shirras, A.D., McAinsh, M. 07/2005 In: Comparative Biochemistry and Physiology - Part A: Molecular and Integrative Physiology. 141, 3 Supp, p. S273-S274. Drosophila melanogaster NEP2 is a new soluble member of the neprilysin family of endopeptidases with implications for reproduction and renal function.Thomas, J.E., Rylett, C.M., Carhan, A., Bland, N.D., Bingham, R.J., Shirras, A.D., Turner, A.J., Isaac, R.E. 2005 In: Biochemical Journal. 386, 2, p. 357-366. 10 p. The angiotensin-converting enzyme (ACE) gene family of Anopheles gambiae.Burnham, S., Smith, J.A., Lee, A.J., Isaac, R.E., Shirras, A.D. 2005 In: BMC Genomics. 6, p. 172. Proctolin in the post-genomic era: new insights and challengesIsaac, R.E., Taylor, C.A., Hamasaka, Y., N?ssel, D.R., Shirras, A.D. 10/2004 In: Invertebrate Neuroscience. 5, 2, p. 51-64. 14 p. Molecular dissection of the ozone stress responses.Short, E., McAinsh, M., Shirras, A.D. 03/2004 In: Comparative Biochemistry and Physiology - Part A: Molecular and Integrative Physiology. 137, 3 Supp, p. S202.